Protein: SYTC
Threonine--tRNA ligase 1, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase 1)

Gene: SYTC, TARS1
Organism: Homo sapiens
Interactions: 140
UniProt ID: P26639

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0004829 - threonine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006435 - threonyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

58217

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

3

10

High-throughput

0.871

High

226576

PRKN
E3 ubiquitin-protein ligase parkin

3

6

High-throughput

0.640

High

643748

CUL3
Cullin-3

2

6

High-throughput

0.611

High

581449

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.601

High

643722

BRCA1
Breast cancer type 1 susceptibility protein

2

4

High-throughput

0.586

High

643757

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.571

High

128809

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

1

High-throughput

0.536

High

201224

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

High-throughput

0.536

High

237165

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.536

High

362840

FINC
Fibronectin

1

3

High-throughput

0.536

High

643730

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

2

High-throughput

0.536

High

643742

KPCZ
Protein kinase C zeta type

1

2

High-throughput

0.536

High

643744

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

4

High-throughput

0.536

High

643747

CUL1
Cullin-1

1

6

High-throughput

0.536

High

643755

MYLK
Myosin light chain kinase, smooth muscle

1

3

High-throughput

0.536

High

643765

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.536

High

643800

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

2

High-throughput

0.536

High

643808

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

243966

BRD4
Bromodomain-containing protein 4

2

2

High-throughput

0.533

High

643785

CG025
UPF0415 protein C7orf25

1

1

High-throughput

0.523

High

388238

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

617434

CRCM
Colorectal mutant cancer protein

1

2

High-throughput

0.515

High

643736

ELF3
ETS-related transcription factor Elf-3

1

1

High-throughput

0.515

High

643807

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.515

High

643779

OPTN
Optineurin

1

2

High-throughput

0.515

High

643787

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

643790

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.513

High

643723

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

643775

NDRG1
Protein NDRG1

1

0

Small-scale

0.493

High

211425

ST1B1
Sulfotransferase 1B1

1

0

High-throughput

0.493

High

259420

NIPS2
Protein NipSnap homolog 2

1

2

High-throughput

0.489

High

643759

C102B
Coiled-coil domain-containing protein 102B

1

2

High-throughput

0.489

High

643780

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

119183

LEG9
Galectin-9

1

2

High-throughput

0.479

High

166671

CE290
Centrosomal protein of 290 kDa

1

2

High-throughput

0.479

High

243298

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.479

High

253314

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

1

High-throughput

0.479

High

294396

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

298177

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

337964

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

354300

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

381805

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

High-throughput

0.479

High

384303

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

386138

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

397792

ISG15
Ubiquitin-like protein ISG15

1

3

High-throughput

0.479

High

431553

HS90A
Heat shock protein HSP 90-alpha

1

7

High-throughput

0.479

High

455111

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

530440

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

542193

PLAK
Junction plakoglobin

1

1

High-throughput

0.479

High

588838

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

1

High-throughput

0.479

High

625127

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

636458

DNJB2
DnaJ homolog subfamily B member 2

1

1

High-throughput

0.479

High

636808

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

643716

PML
Protein PML

1

4

High-throughput

0.479

High

643717

DNJA1
DnaJ homolog subfamily A member 1

1

3

High-throughput

0.479

High

643718

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

643724

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

643725

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

643727

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.479

High

643734

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

643737

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

643739

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

High-throughput

0.479

High

643740

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

1

High-throughput

0.479

High

643741

1433F
14-3-3 protein eta

1

2

High-throughput

0.479

High

643745

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

643749

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.479

High

643750

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

643751

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

7

High-throughput

0.479

High

643753

CUL7
Cullin-7

1

1

High-throughput

0.479

High

643754

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

643760

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

643762

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

643764

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

High-throughput

0.479

High

643772

TITIN
Titin

1

5

High-throughput

0.479

High

643773

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

643774

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

643777

FBXW7
F-box/WD repeat-containing protein 7

1

3

Small-scale

0.479

High

643778

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

643782

RING2
E3 ubiquitin-protein ligase RING2

1

5

High-throughput

0.479

High

643783

NECD
Necdin

1

1

High-throughput

0.479

High

643784

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.479

High

643789

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

643791

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

643792

Q9H4D1
Protein kinase

1

2

High-throughput

0.479

High

643795

ANLN
Anillin

1

2

High-throughput

0.479

High

643797

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

643799

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

643801

TRI33
E3 ubiquitin-protein ligase TRIM33

1

2

High-throughput

0.479

High

643802

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.479

High

643806

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

3

High-throughput

0.479

High

275540

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

2

High-throughput

0.470

High

376069

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

430059

PROF1
Profilin-1

1

0

High-throughput

0.458

High

643719

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

643721

TALDO
Transaldolase

1

0

High-throughput

0.458

High

643726

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

643729

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

643733

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.458

High

643735

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

643743

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

643746

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

0

High-throughput

0.458

High

643766

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

643786

DDX50
ATP-dependent RNA helicase DDX50

1

0

High-throughput

0.458

High

643805

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

496349

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

643731

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

643756

NEDD8
NEDD8

1

2

Small-scale

0.445

High

643803

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

282825

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

4

High-throughput

0.437

High

329383

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

345977

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.437

High

398830

HMGN2
Non-histone chromosomal protein HMG-17

1

1

High-throughput

0.437

High

488909

H14
Histone H1.4

1

4

High-throughput

0.437

High

551993

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

569221

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.437

High

643715

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

643720

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

643738

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

2

High-throughput

0.437

High

643752

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

643761

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

643763

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

643767

DJC10
DnaJ homolog subfamily C member 10

1

1

High-throughput

0.437

High

643768

RHG24
Rho GTPase-activating protein 24

1

1

High-throughput

0.437

High

643769

ARL10
ADP-ribosylation factor-like protein 10

1

2

High-throughput

0.437

High

643771

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.437

High

643776

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.437

High

643794

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

643798

RBM27
RNA-binding protein 27

1

2

High-throughput

0.437

High

643804

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

643781

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

401452

JUN
Transcription factor Jun

1

8

High-throughput

0.407

High

643728

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

643788

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

225530

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

279083

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.249

Low

643758

OTUD1
OTU domain-containing protein 1

1

0

High-throughput

0.249

Low

643770

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.249

Low

643793

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.249

Low

643796

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

643732

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024