Protein: UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)

Gene: UCHL1
Organism: Homo sapiens
Interactions: 239
UniProt ID: P09936

Gene Ontology (top 5):
GO:0002176 - male germ cell proliferation
GO:0002931 - response to ischemia
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

456475

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

23

15

Small-scale

0.990

High

226330

PRKN
E3 ubiquitin-protein ligase parkin

4

13

Small-scale

0.899

High

456575

NEDD8
NEDD8

2

14

High-throughput

0.811

High

385962

P53
Cellular tumor antigen p53

5

1

Small-scale

0.706

High

337823

EGFR
Epidermal growth factor receptor

4

3

Small-scale

0.705

High

393986

A4
Amyloid-beta precursor protein

3

1

Small-scale

0.667

High

456658

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

3

10

High-throughput

0.662

High

456667

TRAF6
TNF receptor-associated factor 6

3

6

Small-scale

0.650

High

431453

HS90A
Heat shock protein HSP 90-alpha

3

6

Small-scale

0.646

High

456544

CBX1
Chromobox protein homolog 1

2

4

High-throughput

0.628

High

456472

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

6

Small-scale

0.618

High

456536

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

13

Small-scale

0.618

High

456619

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.618

High

456631

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.618

High

456506

AKT1
RAC-alpha serine/threonine-protein kinase

2

5

Small-scale

0.614

High

456567

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

2

1

High-throughput

0.601

High

456645

ATG5
Autophagy protein 5

2

1

High-throughput

0.601

High

456482

LAMP2
Lysosome-associated membrane glycoprotein 2

3

1

Small-scale

0.599

High

456478

HSP7C
Heat shock cognate 71 kDa protein

2

6

Small-scale

0.595

High

456474

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

15

High-throughput

0.590

High

456480

CDK4
Cyclin-dependent kinase 4

1

7

Small-scale

0.586

High

456499

CDK2
Cyclin-dependent kinase 2

2

4

Small-scale

0.584

High

456580

HIF1A
Hypoxia-inducible factor 1-alpha

2

3

Small-scale

0.584

High

456507

AKT2
RAC-beta serine/threonine-protein kinase

1

6

Small-scale

0.578

High

456573

TERF2
Telomeric repeat-binding factor 2

2

0

Small-scale

0.575

High

445802

ADA2A
Alpha-2A adrenergic receptor

1

3

Small-scale

0.573

High

456620

CSN5
COP9 signalosome complex subunit 5

1

12

Small-scale

0.573

High

456534

RS6
Small ribosomal subunit protein eS6

2

2

High-throughput

0.571

High

456564

CUL3
Cullin-3

2

2

High-throughput

0.571

High

456586

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

4

High-throughput

0.571

High

456652

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.568

High

456578

SMN
Survival motor neuron protein

1

1

Small-scale

0.561

High

456576

EZH2
Histone-lysine N-methyltransferase EZH2

2

0

Small-scale

0.559

High

239481

EIF1B
Eukaryotic translation initiation factor 1b

2

2

High-throughput

0.549

High

270562

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

4

High-throughput

0.541

High

456639

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

6

High-throughput

0.541

High

456484

NCAM1
Neural cell adhesion molecule 1

1

1

Small-scale

0.536

High

156997

AIM2
Interferon-inducible protein AIM2

1

2

High-throughput

0.536

High

201185

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

336324

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

456515

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

8

High-throughput

0.536

High

456516

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

456548

CDK5
Cyclin-dependent kinase 5

1

4

Small-scale

0.536

High

456555

KPCZ
Protein kinase C zeta type

1

6

High-throughput

0.536

High

456572

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

1

High-throughput

0.536

High

456581

IF16
Gamma-interferon-inducible protein 16

1

2

High-throughput

0.536

High

456590

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.536

High

456668

SAR1B
Small COPII coat GTPase SAR1B

1

3

High-throughput

0.536

High

456634

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.518

High

456547

CDK6
Cyclin-dependent kinase 6

1

7

Small-scale

0.515

High

456554

K1C17
Keratin, type I cytoskeletal 17

1

10

High-throughput

0.515

High

177438

NVL
Nuclear valosin-containing protein-like

1

5

High-throughput

0.515

High

177646

BIRC5
Baculoviral IAP repeat-containing protein 5

1

2

High-throughput

0.515

High

321369

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

1

High-throughput

0.515

High

456497

RO52
E3 ubiquitin-protein ligase TRIM21

1

3

High-throughput

0.515

High

456535

RAN
GTP-binding nuclear protein Ran

1

8

High-throughput

0.515

High

456537

AP2B1
AP-2 complex subunit beta

1

6

High-throughput

0.515

High

456610

REBL1
GTPase RhebL1

1

7

High-throughput

0.515

High

456626

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

1

High-throughput

0.515

High

456635

UBAC1
Ubiquitin-associated domain-containing protein 1

1

2

High-throughput

0.515

High

456642

LDH6B
L-lactate dehydrogenase A-like 6B

1

6

High-throughput

0.515

High

456656

EVL
Ena/VASP-like protein

1

3

High-throughput

0.515

High

456661

RN112
RING finger protein 112

1

4

High-throughput

0.515

High

456663

CSN3
COP9 signalosome complex subunit 3

1

9

High-throughput

0.515

High

456613

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

456539

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.508

High

456629

RANB9
Ran-binding protein 9

1

5

Small-scale

0.508

High

456485

PA2GA
Phospholipase A2, membrane associated

1

2

Small-scale

0.501

High

456491

ADA2B
Alpha-2B adrenergic receptor

1

3

Small-scale

0.501

High

456493

ADA2C
Alpha-2C adrenergic receptor

1

3

Small-scale

0.501

High

456542

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

Small-scale

0.501

High

456621

TRI63
E3 ubiquitin-protein ligase TRIM63

1

18

High-throughput

0.501

High

456628

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

12

High-throughput

0.501

High

456641

TRI54
Tripartite motif-containing protein 54

1

18

High-throughput

0.501

High

456666

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

9

High-throughput

0.501

High

456553

TIE2
Angiopoietin-1 receptor

1

4

High-throughput

0.500

High

456523

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

Small-scale

0.493

High

456584

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.493

High

456494

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

0

High-throughput

0.493

High

456531

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

0

High-throughput

0.493

High

456604

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.493

High

456607

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.493

High

456614

BRK1
Protein BRICK1

1

0

High-throughput

0.493

High

456627

LMTK3
Serine/threonine-protein kinase LMTK3

1

9

High-throughput

0.489

High

117564

MYO1C
Unconventional myosin-Ic

1

6

Small-scale

0.479

High

118680

AIP
AH receptor-interacting protein

1

4

Small-scale

0.479

High

128001

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

11

High-throughput

0.479

High

209611

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

214477

MYO1B
Unconventional myosin-Ib

1

9

Small-scale

0.479

High

252897

MITF
Microphthalmia-associated transcription factor

1

1

Small-scale

0.479

High

265496

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

5

Small-scale

0.479

High

308346

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

345762

MYC
Myc proto-oncogene protein

1

2

Small-scale

0.479

High

384147

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

411282

INSR
Insulin receptor

1

9

High-throughput

0.479

High

414694

CDK1
Cyclin-dependent kinase 1

1

4

Small-scale

0.479

High

417115

ENOA
Alpha-enolase

1

4

Small-scale

0.479

High

418853

TPM3
Tropomyosin alpha-3 chain

1

4

Small-scale

0.479

High

423112

PDIA1
Protein disulfide-isomerase

1

5

High-throughput

0.479

High

436059

ANXA6
Annexin A6

1

10

Small-scale

0.479

High

437826

HS90B
Heat shock protein HSP 90-beta

1

6

Small-scale

0.479

High

456477

BIP
Endoplasmic reticulum chaperone BiP

1

8

Small-scale

0.479

High

456479

PYGB
Glycogen phosphorylase, brain form

1

1

Small-scale

0.479

High

456486

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.479

High

456489

DESP
Desmoplakin

1

13

Small-scale

0.479

High

456490

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

456492

RL17
Large ribosomal subunit protein uL22

1

1

Small-scale

0.479

High

456495

K2C4
Keratin, type II cytoskeletal 4

1

10

High-throughput

0.479

High

456498

CRCM
Colorectal mutant cancer protein

1

7

High-throughput

0.479

High

456500

PSA4
Proteasome subunit alpha type-4

1

15

Small-scale

0.479

High

456501

IKBA
NF-kappa-B inhibitor alpha

1

7

Small-scale

0.479

High

456502

DNMT1
DNA

1

1

Small-scale

0.479

High

456504

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

456508

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

456509

CTNB1
Catenin beta-1

1

8

Small-scale

0.479

High

456510

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

456511

MYH9
Myosin-9

1

6

Small-scale

0.479

High

456512

MYH10
Myosin-10

1

6

Small-scale

0.479

High

456513

FUS
RNA-binding protein FUS

1

5

Small-scale

0.479

High

456514

MYH11
Myosin-11

1

6

Small-scale

0.479

High

456519

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

11

Small-scale

0.479

High

456522

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

13

Small-scale

0.479

High

456524

TGM4
Protein-glutamine gamma-glutamyltransferase 4

1

1

Small-scale

0.479

High

456525

EFTU
Elongation factor Tu, mitochondrial

1

4

Small-scale

0.479

High

456526

CSRP3
Cysteine and glycine-rich protein 3

1

3

Small-scale

0.479

High

456527

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

456529

KLF3
Krueppel-like factor 3

1

4

High-throughput

0.479

High

456530

PSA6
Proteasome subunit alpha type-6

1

16

Small-scale

0.479

High

456533

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

Small-scale

0.479

High

456538

1433Z
14-3-3 protein zeta/delta

1

8

Small-scale

0.479

High

456540

TPM4
Tropomyosin alpha-4 chain

1

4

Small-scale

0.479

High

456541

ACTC
Actin, alpha cardiac muscle 1

1

9

High-throughput

0.479

High

456545

SMAD3
Mothers against decapentaplegic homolog 3

1

7

Small-scale

0.479

High

456546

VIGLN
Vigilin

1

11

High-throughput

0.479

High

456551

DSG1
Desmoglein-1

1

3

Small-scale

0.479

High

456552

RL18A
Large ribosomal subunit protein eL20

1

1

Small-scale

0.479

High

456557

U17LO
Ubiquitin carboxyl-terminal hydrolase 17-like protein 24

1

7

Small-scale

0.479

High

456558

MERTK
Tyrosine-protein kinase Mer

1

6

High-throughput

0.479

High

456560

TRAF3
TNF receptor-associated factor 3

1

6

Small-scale

0.479

High

456561

SMAD4
Mothers against decapentaplegic homolog 4

1

7

Small-scale

0.479

High

456562

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

456563

SQSTM
Sequestosome-1

1

3

High-throughput

0.479

High

456566

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

3

Small-scale

0.479

High

456568

SRC8
Src substrate cortactin

1

5

Small-scale

0.479

High

456570

STAT4
Signal transducer and activator of transcription 4

1

1

Small-scale

0.479

High

456571

CUL7
Cullin-7

1

1

High-throughput

0.479

High

456574

SMAD2
Mothers against decapentaplegic homolog 2

1

7

Small-scale

0.479

High

456577

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.479

High

456579

DREB
Drebrin

1

4

Small-scale

0.479

High

456585

FILA2
Filaggrin-2

1

5

Small-scale

0.479

High

456593

WDR82
WD repeat-containing protein 82

1

3

Small-scale

0.479

High

456595

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

456598

TBA1A
Tubulin alpha-1A chain

1

10

Small-scale

0.479

High

456600

ZFY16
Zinc finger FYVE domain-containing protein 16

1

1

Small-scale

0.479

High

456605

HORN
Hornerin

1

5

Small-scale

0.479

High

456606

RPTOR
Regulatory-associated protein of mTOR

1

5

Small-scale

0.479

High

456612

CIP2A
Protein CIP2A

1

3

Small-scale

0.479

High

456616

ATX2L
Ataxin-2-like protein

1

2

Small-scale

0.479

High

456630

NECD
Necdin

1

2

High-throughput

0.479

High

456637

TRAF4
TNF receptor-associated factor 4

1

4

Small-scale

0.479

High

456638

TBB2B
Tubulin beta-2B chain

1

11

Small-scale

0.479

High

456643

AICDA
Single-stranded DNA cytosine deaminase

1

1

Small-scale

0.479

High

456646

Q9H4D1
Protein kinase

1

7

High-throughput

0.479

High

456653

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.479

High

456655

EPHA6
Ephrin type-A receptor 6

1

3

High-throughput

0.479

High

456657

ANC2
Anaphase-promoting complex subunit 2

1

3

High-throughput

0.479

High

456659

TNIK
TRAF2 and NCK-interacting protein kinase

1

2

High-throughput

0.479

High

456660

BAG5
BAG family molecular chaperone regulator 5

1

4

High-throughput

0.479

High

456665

ANKR6
Ankyrin repeat domain-containing protein 6

1

8

Small-scale

0.479

High

59938

A4FUJ8
MKL1 protein

1

2

High-throughput

0.470

High

456589

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

1

High-throughput

0.470

High

456599

Q7KZS0
SUMO-conjugating enzyme UBC9

1

2

High-throughput

0.470

High

456615

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

5

High-throughput

0.470

High

58495

CCD66
Coiled-coil domain-containing protein 66

1

0

Small-scale

0.458

High

310002

PDE8B
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

1

0

Small-scale

0.458

High

363699

ALBU
Albumin

1

0

Small-scale

0.458

High

414136

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.458

High

429804

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

456473

PA24B
Cytosolic phospholipase A2 beta

1

0

Small-scale

0.458

High

456517

SYUA
Alpha-synuclein

1

0

Small-scale

0.458

High

456518

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

456520

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.458

High

456532

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

456549

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

456565

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

Small-scale

0.458

High

456583

ZN792
Zinc finger protein 792

1

0

Small-scale

0.458

High

456592

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

456597

CYS1
Cystin-1

1

0

Small-scale

0.458

High

456601

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

0

Small-scale

0.458

High

456602

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

456603

C163A
Scavenger receptor cysteine-rich type 1 protein M130

1

0

Small-scale

0.458

High

456636

DERL1
Derlin-1

1

0

Small-scale

0.458

High

456647

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

456648

NMRL1
NmrA-like family domain-containing protein 1

1

0

Small-scale

0.458

High

456649

NGB
Neuroglobin

1

0

High-throughput

0.458

High

456654

SPAT7
Spermatogenesis-associated protein 7

1

0

Small-scale

0.458

High

456664

RXLT1
Ribitol-5-phosphate xylosyltransferase 1

1

0

Small-scale

0.458

High

428887

ADRB2
Beta-2 adrenergic receptor

1

1

Small-scale

0.457

High

456496

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

Small-scale

0.457

High

456556

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.457

High

445814

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

5

High-throughput

0.457

High

456505

EPHA8
Ephrin type-A receptor 8

1

4

High-throughput

0.457

High

456476

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

456521

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.445

High

456528

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.445

High

456625

OTUB1
Ubiquitin thioesterase OTUB1

1

2

High-throughput

0.445

High

166097

SYNEM
Synemin

1

13

Small-scale

0.437

High

392991

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

2

High-throughput

0.437

High

456481

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

456503

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.437

High

456550

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

456591

FBX42
F-box only protein 42

1

6

High-throughput

0.437

High

456594

DYH12
Dynein axonemal heavy chain 12

1

1

Small-scale

0.437

High

456608

ANR31
Ankyrin repeat domain-containing protein 31

1

7

Small-scale

0.437

High

456617

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

456618

CPT1B
Carnitine O-palmitoyltransferase 1, muscle isoform

1

1

Small-scale

0.437

High

456622

FKB10
Peptidyl-prolyl cis-trans isomerase FKBP10

1

7

Small-scale

0.437

High

456650

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

1

Small-scale

0.437

High

456662

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

456483

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

456596

NEK10
Serine/threonine-protein kinase Nek10

1

5

High-throughput

0.407

High

456609

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.279

Low

456559

PDZ1I
PDZK1-interacting protein 1

1

0

High-throughput

0.268

Low

456611

ENKUR
Enkurin

1

0

High-throughput

0.268

Low

456633

Q9BR81
Protocadherin gamma subfamily C, 3

1

0

High-throughput

0.268

Low

456487

ZNF44
Zinc finger protein 44

1

0

Small-scale

0.249

Low

456543

DCD
Dermcidin

1

0

Small-scale

0.249

Low

456569

KCNB1
Potassium voltage-gated channel subfamily B member 1

1

0

Small-scale

0.249

Low

456582

LAMA3
Laminin subunit alpha-3

1

0

Small-scale

0.249

Low

456587

KPLCE
Protein KPLCE

1

0

Small-scale

0.249

Low

456588

S31G1
Spermatogenesis-associated protein 31G1

1

0

Small-scale

0.249

Low

456623

SYTL4
Synaptotagmin-like protein 4

1

0

Small-scale

0.249

Low

456624

RRFM
Ribosome-recycling factor, mitochondrial

1

0

Small-scale

0.249

Low

456632

SYT15
Synaptotagmin-15

1

0

Small-scale

0.249

Low

456640

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.249

Low

456644

S22A4
Solute carrier family 22 member 4

1

0

Small-scale

0.249

Low

456651

SCN3A
Sodium channel protein type 3 subunit alpha

1

0

Small-scale

0.249

Low

456488

ITF2
Transcription factor 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024