Protein: IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA)

Gene: IKKA, Chuk
Organism: Mus musculus
Interactions: 38
UniProt ID: Q60680

Gene Ontology (top 5):
GO:0002011 - morphogenesis of an epithelial sheet
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

312496

NEMO
NF-kappa-B essential modulator

11

20

Small-scale

0.970

High

312149

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

4

19

Small-scale

0.873

High

1221344

IKBB
NF-kappa-B inhibitor beta

3

20

Small-scale

0.845

High

59708

TPX2
Targeting protein for Xklp2

1

4

Small-scale

0.618

High

90690

NLRC5
Protein NLRC5

1

15

Small-scale

0.618

High

1189492

NLRX1
NLR family member X1

1

13

Small-scale

0.618

High

1221345

GIT1
ARF GTPase-activating protein GIT1

1

4

High-throughput

0.590

High

1221355

RAB5A
Ras-related protein Rab-5A

1

8

High-throughput

0.590

High

509087

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

17

High-throughput

0.579

High

1021386

NBR1
Next to BRCA1 gene 1 protein

1

5

Small-scale

0.553

High

1221350

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.536

High

72839

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

2

High-throughput

0.528

High

1190384

TAXB1
Tax1-binding protein 1 homolog

1

20

Small-scale

0.528

High

1000414

IRF7
Interferon regulatory factor 7

1

15

Small-scale

0.515

High

852342

CBP
Histone lysine acetyltransferase CREBBP

1

14

Small-scale

0.506

High

518549

ANXA1
Annexin A1

1

8

Small-scale

0.479

High

669413

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

18

Small-scale

0.479

High

693161

TNR5
Tumor necrosis factor receptor superfamily member 5

1

18

Small-scale

0.479

High

1021905

SMN
Survival motor neuron protein

1

4

Small-scale

0.479

High

1221353

RNF31
E3 ubiquitin-protein ligase RNF31

1

12

Small-scale

0.479

High

1221356

MTOR
Serine/threonine-protein kinase mTOR

1

20

Small-scale

0.479

High

1221358

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

15

Small-scale

0.479

High

98056

DESP
Desmoplakin

1

20

High-throughput

0.457

High

385199

K1C10
Keratin, type I cytoskeletal 10

1

9

High-throughput

0.457

High

1189631

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

High-throughput

0.457

High

1221348

KI20B
Kinesin-like protein KIF20B

1

10

High-throughput

0.457

High

1221359

DX39B
Spliceosome RNA helicase Ddx39b

1

20

High-throughput

0.457

High

866564

TNR4
Tumor necrosis factor receptor superfamily member 4

1

18

Small-scale

0.457

High

1221346

A16L2
Protein Atg16l2

1

13

Small-scale

0.439

High

1221349

CBAR1
CBY1-interacting BAR domain-containing protein 1

1

0

High-throughput

0.438

High

148589

SNP23
Synaptosomal-associated protein 23

1

3

Small-scale

0.437

High

85512

B7ZNY0
Pde4dip protein

1

20

High-throughput

0.417

High

148571

PEX5
Peroxisomal targeting signal 1 receptor

1

5

High-throughput

0.417

High

1221347

SESD1
SEC14 domain and spectrin repeat-containing protein 1

1

12

High-throughput

0.417

High

1221351

ARFP2
Arfaptin-2

1

2

High-throughput

0.417

High

1221354

ANX13
Annexin A13

1

8

High-throughput

0.417

High

1221357

TRI44
Tripartite motif-containing protein 44

1

20

High-throughput

0.417

High

1221352

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025