Protein: NEMO
NF-kappa-B essential modulator (NEMO) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)

Gene: NEMO, Ikbkg
Organism: Mus musculus
Interactions: 60
UniProt ID: O88522

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000922 - spindle pole
GO:0001782 - B cell homeostasis
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

312120

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

18

17

Small-scale

0.984

High

312496

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

11

20

Small-scale

0.970

High

312522

IKBA
NF-kappa-B inhibitor alpha

5

20

Small-scale

0.917

High

312467

NEMO
NF-kappa-B essential modulator

4

16

Small-scale

0.874

High

312498

IKBB
NF-kappa-B inhibitor beta

2

20

Small-scale

0.778

High

312511

RNF31
E3 ubiquitin-protein ligase RNF31

4

16

Small-scale

0.705

High

312514

IKBZ
NF-kappa-B inhibitor zeta

1

15

High-throughput

0.698

High

312481

TRAF6
TNF receptor-associated factor 6

4

19

Small-scale

0.680

High

312497

TNAP3
Tumor necrosis factor alpha-induced protein 3

3

12

Small-scale

0.680

High

312473

TNR1A
Tumor necrosis factor receptor superfamily member 1A

4

7

Small-scale

0.676

High

312482

TANK
TRAF family member-associated NF-kappa-B activator

3

1

Small-scale

0.640

High

312499

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

3

20

Small-scale

0.640

High

312519

TBK1
Serine/threonine-protein kinase TBK1

3

19

Small-scale

0.640

High

312501

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

7

Small-scale

0.601

High

312468

TNFA
Tumor necrosis factor

2

3

Small-scale

0.584

High

312475

AKT1
RAC-alpha serine/threonine-protein kinase

2

13

Small-scale

0.584

High

312476

TRAF2
TNF receptor-associated factor 2

2

14

Small-scale

0.584

High

312504

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

3

Small-scale

0.584

High

312469

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

11

High-throughput

0.579

High

312478

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

5

Small-scale

0.571

High

312518

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

11

Small-scale

0.561

High

312472

HS71B
Heat shock 70 kDa protein 1B

2

10

Small-scale

0.549

High

312471

TFE2
Transcription factor E2-alpha

1

2

High-throughput

0.541

High

312490

NFE2
Transcription factor NF-E2 45 kDa subunit

1

2

High-throughput

0.541

High

312500

TS101
Tumor susceptibility gene 101 protein

1

2

High-throughput

0.541

High

312503

MAML1
Mastermind-like protein 1

1

7

High-throughput

0.541

High

312474

TNR5
Tumor necrosis factor receptor superfamily member 5

1

7

Small-scale

0.515

High

312516

TLR4
Toll-like receptor 4

1

3

Small-scale

0.515

High

312510

SHRPN
Sharpin

1

3

Small-scale

0.500

High

63090

A5D6Q2
Nuclear receptor coactivator 3

1

11

High-throughput

0.481

High

107132

F8VQ72
Mitogen-activated protein kinase kinase kinase 1

1

3

Small-scale

0.479

High

312470

ANXA1
Annexin A1

1

4

Small-scale

0.479

High

312479

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

8

Small-scale

0.479

High

312480

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

Small-scale

0.479

High

312483

IRF7
Interferon regulatory factor 7

1

2

Small-scale

0.479

High

312484

BID
BH3-interacting domain death agonist

1

1

Small-scale

0.479

High

312486

SMN
Survival motor neuron protein

1

2

Small-scale

0.479

High

312487

KPCT
Protein kinase C theta type

1

9

Small-scale

0.479

High

312488

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

13

Small-scale

0.479

High

312492

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.479

High

312494

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

1

Small-scale

0.479

High

312502

SENP6
Sentrin-specific protease 6

1

1

Small-scale

0.479

High

312507

TRI29
Tripartite motif-containing protein 29

1

13

Small-scale

0.479

High

312508

MAVS
Mitochondrial antiviral-signaling protein

1

8

Small-scale

0.479

High

312509

SOCS7
Suppressor of cytokine signaling 7

1

2

Small-scale

0.479

High

312513

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

Small-scale

0.479

High

312515

RHOA
Transforming protein RhoA

1

20

Small-scale

0.479

High

312517

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

20

Small-scale

0.479

High

312520

GSK3B
Glycogen synthase kinase-3 beta

1

12

Small-scale

0.479

High

312521

BCL10
B-cell lymphoma/leukemia 10

1

1

Small-scale

0.479

High

312493

NLRX1
NLR family member X1

1

3

Small-scale

0.470

High

312491

PADI2
Protein-arginine deiminase type-2

1

0

Small-scale

0.458

High

312489

Q05BA5
Nuclear receptor coactivator

1

10

High-throughput

0.457

High

312477

TNR4
Tumor necrosis factor receptor superfamily member 4

1

7

Small-scale

0.457

High

312495

ZC12A
Endoribonuclease ZC3H12A

1

2

Small-scale

0.445

High

312512

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

20

Small-scale

0.445

High

312506

ANGL8
Angiopoietin-like protein 8

1

1

Small-scale

0.437

High

312505

RHBD3
Rhomboid domain-containing protein 3

1

0

Small-scale

0.292

High

312485

NKX32
Homeobox protein Nkx-3.2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025