Protein: IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) (Serine/threonine protein kinase IKBKB) (EC 2.7.11.1)

Gene: IKKB, Ikbkb
Organism: Mus musculus
Interactions: 61
UniProt ID: O88351

Gene Ontology (top 5):
GO:0001782 - B cell homeostasis
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

312120

NEMO
NF-kappa-B essential modulator

18

17

Small-scale

0.984

High

312175

IKBA
NF-kappa-B inhibitor alpha

4

20

Small-scale

0.885

High

312150

IKBB
NF-kappa-B inhibitor beta

4

20

Small-scale

0.882

High

312149

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

4

19

Small-scale

0.873

High

312129

AKT1
RAC-alpha serine/threonine-protein kinase

2

20

Small-scale

0.754

High

312154

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

8

Small-scale

0.737

High

312119

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

18

Small-scale

0.691

High

312125

TNR1A
Tumor necrosis factor receptor superfamily member 1A

4

17

Small-scale

0.676

High

90689

NLRC5
Protein NLRC5

1

13

Small-scale

0.618

High

312121

CASP8
Caspase-8

1

6

Small-scale

0.618

High

312134

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

20

Small-scale

0.618

High

312135

SASH1
SAM and SH3 domain-containing protein 1

1

2

Small-scale

0.618

High

312143

KPCT
Protein kinase C theta type

1

20

Small-scale

0.618

High

312144

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

20

Small-scale

0.618

High

312151

ACVL1
Activin receptor type-1-like

1

8

High-throughput

0.618

High

312155

TGFR2
TGF-beta receptor type-2

1

7

High-throughput

0.618

High

312167

RHOA
Transforming protein RhoA

1

11

Small-scale

0.618

High

312169

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

18

Small-scale

0.618

High

312172

TBK1
Serine/threonine-protein kinase TBK1

1

18

Small-scale

0.618

High

312173

KS6A2
Ribosomal protein S6 kinase alpha-2

1

19

Small-scale

0.618

High

312157

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

13

High-throughput

0.590

High

312123

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

1

20

High-throughput

0.579

High

312161

OPTN
Optineurin

1

20

Small-scale

0.579

High

312137

RACK1
Small ribosomal subunit protein RACK1

2

7

Small-scale

0.576

High

312147

KLH21
Kelch-like protein 21

1

8

Small-scale

0.561

High

312160

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

20

Small-scale

0.553

High

148587

SNP23
Synaptosomal-associated protein 23

2

2

Small-scale

0.533

High

312127

TNR5
Tumor necrosis factor receptor superfamily member 5

1

17

Small-scale

0.515

High

312139

IRF7
Interferon regulatory factor 7

1

14

Small-scale

0.515

High

312140

NKX32
Homeobox protein Nkx-3.2

1

2

Small-scale

0.512

High

312122

TNFA
Tumor necrosis factor

1

6

Small-scale

0.479

High

312124

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

2

Small-scale

0.479

High

312130

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

8

Small-scale

0.479

High

312131

HES1
Transcription factor HES-1

1

1

Small-scale

0.479

High

312132

LIT1
Lithostathine-1

1

1

Small-scale

0.479

High

312136

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

11

Small-scale

0.479

High

312138

TANK
TRAF family member-associated NF-kappa-B activator

1

5

Small-scale

0.479

High

312141

SMN
Survival motor neuron protein

1

5

Small-scale

0.479

High

312145

TF65
Transcription factor p65

1

18

Small-scale

0.479

High

312146

STING
Stimulator of interferon genes protein

1

6

High-throughput

0.479

High

312148

FBW1A
F-box/WD repeat-containing protein 1A

1

14

Small-scale

0.479

High

312163

RNF31
E3 ubiquitin-protein ligase RNF31

1

9

Small-scale

0.479

High

312171

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

11

Small-scale

0.479

High

312158

FACD2
Fanconi anemia group D2 protein homolog

1

0

High-throughput

0.458

High

312126

CTNA1
Catenin alpha-1

1

4

High-throughput

0.457

High

312142

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.457

High

312152

DDX5
Probable ATP-dependent RNA helicase DDX5

1

4

High-throughput

0.457

High

312153

CREB3
Cyclic AMP-responsive element-binding protein 3

1

20

High-throughput

0.457

High

312162

5MP1
eIF5-mimic protein 1

1

1

High-throughput

0.457

High

312176

KEAP1
Kelch-like ECH-associated protein 1

1

5

High-throughput

0.457

High

312133

TNR4
Tumor necrosis factor receptor superfamily member 4

1

17

Small-scale

0.457

High

312159

GMPPB
Mannose-1-phosphate guanylyltransferase catalytic subunit beta

1

0

High-throughput

0.438

High

312166

SAS10
Something about silencing protein 10

1

0

High-throughput

0.438

High

312168

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.438

High

312164

CUED2
CUE domain-containing protein 2

1

2

Small-scale

0.437

High

312128

GSTA3
Glutathione S-transferase A3

1

4

High-throughput

0.417

High

312174

SNX1
Sorting nexin-1

1

1

High-throughput

0.417

High

312170

SCNNB
Epithelial sodium channel subunit beta

1

0

Small-scale

0.264

Low

312156

SDC3
Syndecan-3

1

0

High-throughput

0.238

Low

312165

T2EB
General transcription factor IIE subunit 2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025