Protein: A2MG
Alpha-2-macroglobulin (Alpha-2-M) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5)

Gene: A2MG, A2M
Organism: Homo sapiens
Interactions: 243
UniProt ID: P01023

Gene Ontology (top 5):
GO:0001553 - luteinization
GO:0001869 - negative regulation of complement activation, lectin pathway
GO:0002020 - protease binding
GO:0002438 - acute inflammatory response to antigenic stimulus
GO:0004866 - endopeptidase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

344550

HPLN3
Hyaluronan and proteoglycan link protein 3

2

1

High-throughput

0.811

High

344438

PZP
Pregnancy zone protein

2

3

High-throughput

0.802

High

126321

MATN2
Matrilin-2

1

3

High-throughput

0.691

High

198330

KLK10
Kallikrein-10

1

8

High-throughput

0.691

High

344408

KLK1
Kallikrein-1

1

10

Small-scale

0.647

High

344466

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

2

Small-scale

0.647

High

344588

ATS7
A disintegrin and metalloproteinase with thrombospondin motifs 7

1

2

Small-scale

0.647

High

344589

KLK13
Kallikrein-13

1

8

Small-scale

0.647

High

344489

LOXL1
Lysyl oxidase homolog 1

2

2

High-throughput

0.628

High

344503

METRL
Meteorin-like protein

2

1

High-throughput

0.628

High

344570

CRAC1
Cartilage acidic protein 1

2

4

High-throughput

0.628

High

344586

METRN
Meteorin

2

1

High-throughput

0.628

High

344404

A4
Amyloid-beta precursor protein

2

3

Small-scale

0.624

High

344389

A2MG
Alpha-2-macroglobulin

1

3

High-throughput

0.621

High

344409

KLK3
Prostate-specific antigen

1

10

Small-scale

0.618

High

344430

GRAA
Granzyme A

1

9

Small-scale

0.618

High

344583

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

2

Small-scale

0.618

High

344394

APOE
Apolipoprotein E

2

0

Small-scale

0.613

High

344431

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.611

High

344525

GDPD1
Lysophospholipase D GDPD1

3

2

High-throughput

0.609

High

344558

PADC1
Protease-associated domain-containing protein 1

2

0

High-throughput

0.602

High

344413

ELNE
Neutrophil elastase

1

10

Small-scale

0.590

High

344541

IGSF8
Immunoglobulin superfamily member 8

1

0

High-throughput

0.589

High

344395

AMBP
Protein AMBP

2

4

Small-scale

0.584

High

344397

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

3

High-throughput

0.584

High

344406

F13B
Coagulation factor XIII B chain

1

17

Small-scale

0.575

High

344392

NGF
Beta-nerve growth factor

2

0

Small-scale

0.569

High

344405

IL4
Interleukin-4

2

0

Small-scale

0.569

High

344424

TAU
Microtubule-associated protein tau

2

3

Small-scale

0.552

High

344418

PAEP
Glycodelin

1

1

Small-scale

0.550

High

344494

RHEB
GTP-binding protein Rheb

1

1

High-throughput

0.541

High

344399

LCAT
Phosphatidylcholine-sterol acyltransferase

1

0

Small-scale

0.537

High

328077

SG1D1
Secretoglobin family 1D member 1

1

4

High-throughput

0.536

High

344435

BMP7
Bone morphogenetic protein 7

1

4

High-throughput

0.536

High

344533

ITLN2
Intelectin-2

1

1

High-throughput

0.536

High

344555

EGFL8
Epidermal growth factor-like protein 8

1

3

High-throughput

0.536

High

344581

EGFL7
Epidermal growth factor-like protein 7

1

3

High-throughput

0.536

High

344448

PRDX2
Peroxiredoxin-2

1

0

High-throughput

0.518

High

344421

IL8
Interleukin-8

1

1

Small-scale

0.515

High

344420

H2AZ
Histone H2A.Z

1

2

High-throughput

0.515

High

344451

CTNB1
Catenin beta-1

1

1

High-throughput

0.515

High

344456

KSYK
Tyrosine-protein kinase SYK

1

1

High-throughput

0.515

High

344593

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

High-throughput

0.515

High

344488

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

Small-scale

0.514

High

344442

PTX3
Pentraxin-related protein PTX3

1

0

High-throughput

0.513

High

344432

H2AX
Histone H2AX

1

1

High-throughput

0.508

High

344478

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.508

High

344410

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.501

High

344414

MMP2
72 kDa type IV collagenase

1

4

Small-scale

0.501

High

344425

BIP
Endoplasmic reticulum chaperone BiP

1

2

Small-scale

0.501

High

344547

CBPB2
Carboxypeptidase B2

1

2

Small-scale

0.501

High

344485

TIE2
Angiopoietin-1 receptor

1

1

High-throughput

0.500

High

157397

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

1

High-throughput

0.494

High

344423

CP2C8
Cytochrome P450 2C8

1

1

High-throughput

0.494

High

344450

CP2CI
Cytochrome P450 2C18

1

1

High-throughput

0.494

High

344452

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.494

High

344492

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

1

High-throughput

0.494

High

344510

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.494

High

344537

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.494

High

344557

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.494

High

277869

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.493

High

344398

CSF2
Granulocyte-macrophage colony-stimulating factor

1

0

High-throughput

0.493

High

344401

S100B
Protein S100-B

1

0

High-throughput

0.493

High

344411

LYN
Tyrosine-protein kinase Lyn

1

0

High-throughput

0.493

High

344422

THIO
Thioredoxin

1

0

High-throughput

0.493

High

344455

MNDA
Myeloid cell nuclear differentiation antigen

1

0

High-throughput

0.493

High

344481

H31
Histone H3.1

1

0

High-throughput

0.493

High

344511

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

0

High-throughput

0.493

High

344531

BRK1
Protein BRICK1

1

0

High-throughput

0.493

High

344546

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.493

High

344552

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.493

High

344584

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.493

High

182995

P2RX6
P2X purinoceptor 6

1

4

High-throughput

0.489

High

217691

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

1

High-throughput

0.489

High

303616

OR2A4
Olfactory receptor 2A4

1

3

High-throughput

0.489

High

344449

CCR1
C-C chemokine receptor type 1

1

5

High-throughput

0.489

High

344463

STX17
Syntaxin-17

1

4

High-throughput

0.489

High

344483

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

4

High-throughput

0.489

High

344500

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.489

High

344502

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

3

High-throughput

0.489

High

344507

SFXN4
Sideroflexin-4

1

1

High-throughput

0.489

High

344514

CIR1
Corepressor interacting with RBPJ 1

1

1

High-throughput

0.489

High

344515

HIPK1
Homeodomain-interacting protein kinase 1

1

1

High-throughput

0.489

High

344521

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.489

High

344530

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.489

High

344554

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

5

High-throughput

0.489

High

344566

P63
Tumor protein 63

1

1

Small-scale

0.489

High

344569

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.489

High

344585

PHF11
PHD finger protein 11

1

5

High-throughput

0.489

High

344587

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

2

High-throughput

0.489

High

344596

CD11A
Cyclin-dependent kinase 11A

1

1

High-throughput

0.489

High

344601

SSUH2
Protein SSUH2 homolog

1

4

High-throughput

0.489

High

344396

TTHY
Transthyretin

1

0

High-throughput

0.486

High

344436

ANXA7
Annexin A7

1

0

High-throughput

0.486

High

344471

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.486

High

344472

RAP1B
Ras-related protein Rap-1b

1

0

High-throughput

0.486

High

344402

SHBG
Sex hormone-binding globulin

1

1

Small-scale

0.481

High

344439

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

1

High-throughput

0.481

High

344440

IL10
Interleukin-10

1

0

Small-scale

0.480

High

344447

SC6A4
Sodium-dependent serotonin transporter

1

0

Small-scale

0.480

High

344454

LEP
Leptin

1

0

Small-scale

0.480

High

344473

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

0

Small-scale

0.480

High

344419

PGFRB
Platelet-derived growth factor receptor beta

1

0

High-throughput

0.479

High

119065

LEG9
Galectin-9

1

7

Small-scale

0.479

High

121068

LEG8
Galectin-8

1

7

Small-scale

0.479

High

344391

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

4

Small-scale

0.479

High

344426

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

344433

CXA1
Gap junction alpha-1 protein

1

4

Small-scale

0.479

High

344434

LEG3
Galectin-3

1

7

Small-scale

0.479

High

344467

H2B1D
Histone H2B type 1-D

1

3

High-throughput

0.479

High

344474

TGFB2
Transforming growth factor beta-2 proprotein

1

4

Small-scale

0.479

High

344477

H2B1C
Histone H2B type 1-C/E/F/G/I

1

3

High-throughput

0.479

High

344561

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

59936

A4FUJ8
MKL1 protein

1

2

High-throughput

0.470

High

269384

STX11
Syntaxin-11

1

1

High-throughput

0.470

High

344415

HXC4
Homeobox protein Hox-C4

1

3

High-throughput

0.470

High

344464

RAB38
Ras-related protein Rab-38

1

2

High-throughput

0.470

High

344468

KR107
Keratin-associated protein 10-7

1

2

High-throughput

0.470

High

344505

OTU7B
OTU domain-containing protein 7B

1

5

High-throughput

0.470

High

344509

FOXR1
Forkhead box protein R1

1

5

High-throughput

0.470

High

344513

TRI69
E3 ubiquitin-protein ligase TRIM69

1

1

High-throughput

0.470

High

344522

STX19
Syntaxin-19

1

1

High-throughput

0.470

High

344572

DAZ3
Deleted in azoospermia protein 3

1

2

High-throughput

0.470

High

344582

DDX20
Probable ATP-dependent RNA helicase DDX20

1

1

High-throughput

0.470

High

344592

RN112
RING finger protein 112

1

2

High-throughput

0.470

High

344597

FOXA2
Hepatocyte nuclear factor 3-beta

1

4

High-throughput

0.470

High

344462

GEM
GTP-binding protein GEM

1

1

High-throughput

0.464

High

344535

SEPT8
Septin-8

1

1

High-throughput

0.464

High

344559

LST8
Target of rapamycin complex subunit LST8

1

1

High-throughput

0.464

High

344403

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.460

High

344417

ENOG
Gamma-enolase

1

0

High-throughput

0.460

High

344441

DNJB1
DnaJ homolog subfamily B member 1

1

0

High-throughput

0.460

High

344470

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.460

High

344498

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.460

High

344556

MYOC
Myocilin

1

0

Small-scale

0.460

High

344568

RETN
Resistin

1

0

High-throughput

0.460

High

309765

MRP6
ATP-binding cassette sub-family C member 6

1

0

Small-scale

0.458

High

344390

PDGFB
Platelet-derived growth factor subunit B

1

0

Small-scale

0.458

High

344393

TNFA
Tumor necrosis factor

1

0

Small-scale

0.458

High

344407

IL6
Interleukin-6

1

0

Small-scale

0.458

High

344416

FGF2
Fibroblast growth factor 2

1

0

Small-scale

0.458

High

344429

KCRB
Creatine kinase B-type

1

0

High-throughput

0.458

High

344461

MFAP2
Microfibrillar-associated protein 2

1

0

Small-scale

0.458

High

344469

IL2
Interleukin-2

1

0

Small-scale

0.458

High

344476

H4
Histone H4

1

0

High-throughput

0.458

High

344519

SACA3
Sperm acrosome membrane-associated protein 3

1

0

Small-scale

0.458

High

344590

AGO2
Protein argonaute-2

1

0

Small-scale

0.458

High

344412

IGF1R
Insulin-like growth factor 1 receptor

1

1

High-throughput

0.457

High

344487

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

344599

ITM2B
Integral membrane protein 2B

1

5

High-throughput

0.445

High

344465

FBXW4
F-box/WD repeat-containing protein 4

1

2

High-throughput

0.439

High

344486

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

3

High-throughput

0.439

High

344574

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

3

Small-scale

0.439

High

260425

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

304902

DUS14
Dual specificity protein phosphatase 14

1

2

High-throughput

0.437

High

344428

ADT3
ADP/ATP translocase 3

1

3

High-throughput

0.437

High

344458

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.437

High

344475

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

344484

VIGLN
Vigilin

1

1

High-throughput

0.437

High

344490

FOXO1
Forkhead box protein O1

1

7

High-throughput

0.437

High

344491

FOXC1
Forkhead box protein C1

1

7

High-throughput

0.437

High

344518

CUL9
Cullin-9

1

1

High-throughput

0.437

High

344540

TF3B
Transcription factor IIIB 90 kDa subunit

1

1

Small-scale

0.437

High

344562

FACD2
Fanconi anemia group D2 protein

1

6

High-throughput

0.437

High

344563

TRIM6
Tripartite motif-containing protein 6

1

1

Small-scale

0.437

High

344571

ANLN
Anillin

1

2

High-throughput

0.437

High

344573

FBX6
F-box only protein 6

1

4

High-throughput

0.437

High

344577

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

2

High-throughput

0.437

High

344580

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

344501

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

2

0

High-throughput

0.328

High

344520

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

2

0

High-throughput

0.328

High

344526

PGLT1
Protein O-glucosyltransferase 1

2

0

High-throughput

0.328

High

344567

DEFM
Peptide deformylase, mitochondrial

2

0

High-throughput

0.328

High

344575

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

2

0

High-throughput

0.328

High

344499

SMN
Survival motor neuron protein

2

0

High-throughput

0.323

High

119800

SMAP
Small acidic protein

2

0

High-throughput

0.307

High

235252

OGA
Protein O-GlcNAcase

1

0

High-throughput

0.282

High

344445

NOS3
Nitric oxide synthase 3

1

0

High-throughput

0.282

High

344460

RD23A
UV excision repair protein RAD23 homolog A

1

0

High-throughput

0.282

High

344493

ELAV3
ELAV-like protein 3

1

0

High-throughput

0.282

High

344517

TPPC5
Trafficking protein particle complex subunit 5

1

0

High-throughput

0.282

High

344549

PRAM
PML-RARA-regulated adapter molecule 1

1

0

High-throughput

0.282

High

344564

RNF32
RING finger protein 32

1

0

High-throughput

0.282

High

344598

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.282

High

344600

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.282

High

344602

EXOS1
Exosome complex component CSL4

1

0

High-throughput

0.282

High

344459

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.279

Low

344482

PHC1
Polyhomeotic-like protein 1

1

0

High-throughput

0.279

Low

271506

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.268

Low

271718

PRDM1
PR domain zinc finger protein 1

1

0

High-throughput

0.268

Low

344443

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

High-throughput

0.268

Low

344444

TEAD1
Transcriptional enhancer factor TEF-1

1

0

High-throughput

0.268

Low

344479

AP2B1
AP-2 complex subunit beta

1

0

High-throughput

0.268

Low

344504

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.268

Low

344508

AB17C
Alpha/beta hydrolase domain-containing protein 17C

1

0

High-throughput

0.268

Low

344512

SPT12
Spermatogenesis-associated protein 12

1

0

High-throughput

0.268

Low

344516

KRA81
Keratin-associated protein 8-1

1

0

High-throughput

0.268

Low

344524

ZN366
Zinc finger protein 366

1

0

High-throughput

0.268

Low

344528

LNX1
E3 ubiquitin-protein ligase LNX

1

0

High-throughput

0.268

Low

344529

HUMMR
Protein MGARP

1

0

High-throughput

0.268

Low

344532

TWST2
Twist-related protein 2

1

0

High-throughput

0.268

Low

344534

CLC2B
C-type lectin domain family 2 member B

1

0

High-throughput

0.268

Low

344539

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.268

Low

344542

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.268

Low

344544

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.268

Low

344560

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

0

High-throughput

0.268

Low

344565

TDIF1
Deoxynucleotidyltransferase terminal-interacting protein 1

1

0

High-throughput

0.268

Low

344579

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.268

Low

344591

FZD4
Frizzled-4

1

0

High-throughput

0.268

Low

344594

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.268

Low

344595

LHX6
LIM/homeobox protein Lhx6

1

0

High-throughput

0.268

Low

344605

MOFA1
MORF4 family-associated protein 1

1

0

High-throughput

0.268

Low

214818

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.265

Low

279785

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

0

High-throughput

0.265

Low

303780

RPP14
Ribonuclease P protein subunit p14

1

0

High-throughput

0.265

Low

344400

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.265

Low

344427

UMPS
Uridine 5'-monophosphate synthase

1

0

High-throughput

0.265

Low

344446

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.265

Low

344453

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.265

Low

344495

TGIF1
Homeobox protein TGIF1

1

0

High-throughput

0.265

Low

344496

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.265

Low

344497

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.265

Low

344536

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

High-throughput

0.265

Low

344538

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.265

Low

344578

NCDN
Neurochondrin

1

0

High-throughput

0.265

Low

344437

RAB3A
Ras-related protein Rab-3A

1

0

High-throughput

0.251

Low

344480

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.251

Low

344506

SWAP1
ATPase SWSAP1

1

0

High-throughput

0.251

Low

344543

EVI5L
EVI5-like protein

1

0

High-throughput

0.251

Low

344545

STALP
AMSH-like protease

1

0

High-throughput

0.251

Low

344548

EGLN2
Prolyl hydroxylase EGLN2

1

0

High-throughput

0.251

Low

344576

FXL12
F-box/LRR-repeat protein 12

1

0

High-throughput

0.251

Low

344603

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.251

Low

344606

AP1M2
AP-1 complex subunit mu-2

1

0

High-throughput

0.251

Low

126990

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.249

Low

344457

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.249

Low

344523

UBR7
Putative E3 ubiquitin-protein ligase UBR7

1

0

High-throughput

0.249

Low

344527

MTMRE
Myotubularin-related protein 14

1

0

High-throughput

0.249

Low

344551

KCD15
BTB/POZ domain-containing protein KCTD15

1

0

Small-scale

0.249

Low

344553

NECD
Necdin

1

0

High-throughput

0.249

Low

344604

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

120791

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024