Protein: LCMT1
Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) (Protein-leucine O-methyltransferase) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1)

Gene: LCMT1
Organism: Homo sapiens
Interactions: 20
UniProt ID: Q9UIC8

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0003880 - protein C-terminal carboxyl O-methyltransferase activity
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006479 - protein methylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994410

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

3

1

Small-scale

0.847

High

952030

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

2

1

High-throughput

0.789

High

1452211

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

2

0

High-throughput

0.585

High

900548

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.558

High

564523

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

1315725

DND1
Dead end protein homolog 1

1

0

High-throughput

0.513

High

63275

VP37C
Vacuolar protein sorting-associated protein 37C

1

0

High-throughput

0.493

High

1153136

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.486

High

769454

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

799558

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.460

High

831606

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

867831

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

0

High-throughput

0.458

High

942945

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

1100504

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1114592

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1277800

MYH14
Myosin-14

1

0

High-throughput

0.458

High

1335050

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1459221

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

337423

TGDS
dTDP-D-glucose 4,6-dehydratase

1

0

High-throughput

0.279

Low

1255998

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025