Protein: A1AT
Alpha-1-antitrypsin (Alpha-1 protease inhibitor) (Alpha-1-antiproteinase) (Serpin A1) [Cleaved into: Short peptide from AAT (SPAAT)]

Gene: A1AT, SERPINA1
Organism: Homo sapiens
Interactions: 141
UniProt ID: P01009

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

344136

A1AT
Alpha-1-antitrypsin

3

5

Small-scale

0.866

High

344151

ELNE
Neutrophil elastase

2

20

Small-scale

0.778

High

126319

MATN2
Matrilin-2

1

2

High-throughput

0.691

High

198328

KLK10
Kallikrein-10

1

20

High-throughput

0.691

High

344172

CTRL
Chymotrypsin-like protease CTRL-1

1

16

High-throughput

0.691

High

344256

KLK4
Kallikrein-4

1

20

High-throughput

0.691

High

344178

GRAM
Granzyme M

1

20

Small-scale

0.681

High

344192

OS9
Protein OS-9

4

3

Small-scale

0.676

High

344234

DERL1
Derlin-1

4

2

Small-scale

0.676

High

344210

GDPD1
Lysophospholipase D GDPD1

3

1

High-throughput

0.667

High

177775

TMPS2
Transmembrane protease serine 2

1

20

Small-scale

0.647

High

344148

KLK1
Kallikrein-1

1

20

Small-scale

0.647

High

344162

PRTN3
Myeloblastin

1

20

Small-scale

0.647

High

344223

ERLEC
Endoplasmic reticulum lectin 1

3

3

Small-scale

0.640

High

344239

DERL2
Derlin-2

3

2

Small-scale

0.640

High

344146

ALDH2
Aldehyde dehydrogenase, mitochondrial

3

0

High-throughput

0.638

High

344155

HSP7C
Heat shock cognate 71 kDa protein

2

4

High-throughput

0.628

High

344225

SNX27
Sorting nexin-27

2

1

High-throughput

0.628

High

344243

DDX31
ATP-dependent DNA helicase DDX31

2

5

High-throughput

0.628

High

341170

HPT
Haptoglobin

1

20

High-throughput

0.618

High

344137

AACT
Alpha-1-antichymotrypsin

1

5

High-throughput

0.618

High

344149

KLK3
Prostate-specific antigen

1

20

Small-scale

0.618

High

344163

ZA2G
Zinc-alpha-2-glycoprotein

1

2

High-throughput

0.618

High

344252

DD19B
ATP-dependent RNA helicase DDX19B

2

8

High-throughput

0.611

High

344170

CAH8
Carbonic anhydrase-related protein

3

2

High-throughput

0.609

High

344226

ZN558
Zinc finger protein 558

3

3

High-throughput

0.609

High

344164

1433T
14-3-3 protein theta

2

2

High-throughput

0.601

High

344180

TERA
Transitional endoplasmic reticulum ATPase

2

1

Small-scale

0.584

High

344203

SYVN1
E3 ubiquitin-protein ligase synoviolin

2

9

Small-scale

0.584

High

344219

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

2

1

Small-scale

0.584

High

344196

MK06
Mitogen-activated protein kinase 6

2

3

High-throughput

0.574

High

344214

AATC2
Putative aspartate aminotransferase, cytoplasmic 2

2

7

High-throughput

0.574

High

344246

PLK2
Serine/threonine-protein kinase PLK2

2

3

High-throughput

0.558

High

64473

GOG8A
Golgin subfamily A member 8A

1

3

High-throughput

0.536

High

206886

CHSTA
Carbohydrate sulfotransferase 10

1

4

High-throughput

0.536

High

237637

SEP15
Selenoprotein F

1

4

High-throughput

0.536

High

328075

SG1D1
Secretoglobin family 1D member 1

1

4

High-throughput

0.536

High

344181

STX17
Syntaxin-17

1

9

High-throughput

0.536

High

344198

FNDC1
Fibronectin type III domain-containing protein 1

1

5

High-throughput

0.536

High

344201

SFXN4
Sideroflexin-4

1

1

High-throughput

0.536

High

344211

FNDC5
Fibronectin type III domain-containing protein 5

1

6

High-throughput

0.536

High

344216

RHBL4
Rhomboid-related protein 4

1

5

High-throughput

0.536

High

344218

ITLN2
Intelectin-2

1

2

High-throughput

0.536

High

344221

SARAF
Store-operated calcium entry-associated regulatory factor

1

9

High-throughput

0.536

High

344231

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

8

High-throughput

0.536

High

344232

EGFL8
Epidermal growth factor-like protein 8

1

2

High-throughput

0.536

High

344206

SLX4
Structure-specific endonuclease subunit SLX4

2

5

High-throughput

0.521

High

344165

CALX
Calnexin

1

2

Small-scale

0.515

High

344202

K1C27
Keratin, type I cytoskeletal 27

1

0

High-throughput

0.513

High

344242

REN3A
Regulator of nonsense transcripts 3A

1

0

High-throughput

0.513

High

344175

SSRA
Translocon-associated protein subunit alpha

1

0

Small-scale

0.512

High

344253

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

0

Small-scale

0.512

High

257245

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

1

Small-scale

0.506

High

344150

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.501

High

344177

LMAN1
Protein ERGIC-53

1

0

Small-scale

0.493

High

182993

P2RX6
P2X purinoceptor 6

1

1

High-throughput

0.489

High

217689

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

1

High-throughput

0.489

High

239682

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.489

High

312687

CXB5
Gap junction beta-5 protein

1

1

High-throughput

0.489

High

331681

NSD2
Histone-lysine N-methyltransferase NSD2

1

2

High-throughput

0.489

High

344156

CFTR
Cystic fibrosis transmembrane conductance regulator

1

10

High-throughput

0.489

High

344168

CCR1
C-C chemokine receptor type 1

1

7

High-throughput

0.489

High

344182

DSCR6
Protein ripply3

1

6

High-throughput

0.489

High

344187

SSBP2
Single-stranded DNA-binding protein 2

1

5

High-throughput

0.489

High

344188

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

8

High-throughput

0.489

High

344197

CR021
UPF0711 protein C18orf21

1

6

High-throughput

0.489

High

344199

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

6

High-throughput

0.489

High

344204

CIR1
Corepressor interacting with RBPJ 1

1

1

High-throughput

0.489

High

344205

MICU3
Calcium uptake protein 3, mitochondrial

1

1

High-throughput

0.489

High

344207

ELOA2
Elongin-A2

1

2

High-throughput

0.489

High

344208

OR2LD
Olfactory receptor 2L13

1

4

High-throughput

0.489

High

344227

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

2

High-throughput

0.489

High

344235

FUND2
FUN14 domain-containing protein 2

1

2

High-throughput

0.489

High

344244

COE2
Transcription factor COE2

1

4

High-throughput

0.489

High

344245

MBNL1
Muscleblind-like protein 1

1

5

High-throughput

0.489

High

344248

PHF11
PHD finger protein 11

1

8

High-throughput

0.489

High

344249

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

3

High-throughput

0.489

High

344251

HDAC9
Histone deacetylase 9

1

2

High-throughput

0.489

High

344254

SSUH2
Protein SSUH2 homolog

1

7

High-throughput

0.489

High

344228

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

High-throughput

0.481

High

168697

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

6

Small-scale

0.479

High

226208

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

336749

CERU
Ceruloplasmin

1

1

High-throughput

0.479

High

344139

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

1

High-throughput

0.479

High

344140

FINC
Fibronectin

1

5

Small-scale

0.479

High

344141

A1AG1
Alpha-1-acid glycoprotein 1

1

2

High-throughput

0.479

High

344142

VTDB
Vitamin D-binding protein

1

1

High-throughput

0.479

High

344143

TRFE
Serotransferrin

1

2

High-throughput

0.479

High

344144

HEMO
Hemopexin

1

2

High-throughput

0.479

High

344145

STAT
Statherin

1

1

High-throughput

0.479

High

344147

S10A9
Protein S100-A9

1

9

High-throughput

0.479

High

344153

CLUS
Clusterin

1

1

High-throughput

0.479

High

344154

BIP
Endoplasmic reticulum chaperone BiP

1

9

Small-scale

0.479

High

344158

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

344159

LEG3
Galectin-3

1

2

Small-scale

0.479

High

344167

LCN1
Lipocalin-1

1

1

High-throughput

0.479

High

344173

HNF4A
Hepatocyte nuclear factor 4-alpha

1

6

Small-scale

0.479

High

344186

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.479

High

344194

SQSTM
Sequestosome-1

1

1

Small-scale

0.479

High

344195

PROL4
Proline-rich protein 4

1

1

High-throughput

0.479

High

344212

TXND5
Thioredoxin domain-containing protein 5

1

3

Small-scale

0.479

High

344220

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

344237

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

1

Small-scale

0.479

High

344247

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

344250

FBX2
F-box only protein 2

1

5

Small-scale

0.479

High

344152

RAP2A
Ras-related protein Rap-2a

1

3

High-throughput

0.464

High

344169

SDC2
Syndecan-2

1

0

High-throughput

0.460

High

344233

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.460

High

344138

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.458

High

344183

SRP54
Signal recognition particle subunit SRP54

1

0

Small-scale

0.458

High

344189

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.445

High

344166

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.439

High

344193

SMAD4
Mothers against decapentaplegic homolog 4

1

3

High-throughput

0.439

High

260423

PITX3
Pituitary homeobox 3

1

4

Small-scale

0.437

High

344161

HNF1A
Hepatocyte nuclear factor 1-alpha

1

4

Small-scale

0.437

High

344176

SOX2
Transcription factor SOX-2

1

12

High-throughput

0.437

High

344190

FOXO1
Forkhead box protein O1

1

4

High-throughput

0.437

High

344191

RFA4
Replication protein A 30 kDa subunit

1

5

High-throughput

0.437

High

344217

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.437

High

344229

DERL3
Derlin-3

1

2

Small-scale

0.437

High

344236

FACD2
Fanconi anemia group D2 protein

1

11

High-throughput

0.437

High

344240

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.437

High

344185

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.426

High

344200

ICE2
Little elongation complex subunit 2

3

0

High-throughput

0.347

High

344160

CCNA2
Cyclin-A2

1

0

High-throughput

0.279

Low

344179

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

0

High-throughput

0.279

Low

344184

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

344224

SMIM8
Small integral membrane protein 8

1

0

High-throughput

0.279

Low

344241

MIS12
Protein MIS12 homolog

1

0

High-throughput

0.269

Low

344209

MAGB6
Melanoma-associated antigen B6

1

0

High-throughput

0.268

Low

206304

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.251

Low

344171

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.251

Low

344174

GLP1R
Glucagon-like peptide 1 receptor

1

0

Small-scale

0.251

Low

344215

GSDMB
Gasdermin-B

1

0

High-throughput

0.251

Low

344238

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

344213

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

344222

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.249

Low

344230

EYA1
Eyes absent homolog 1

1

0

High-throughput

0.249

Low

344255

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

Small-scale

0.249

Low

344157

TFE2
Transcription factor E2-alpha

1

0

Small-scale

0.238

Low


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Last updated: 15 Jul 2024