Protein: CASPA
Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]

Gene: CASPA, CASP10
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q92851

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1059335

CASP8
Caspase-8

11

17

Small-scale

0.974

High

1026639

FADD
FAS-associated death domain protein

7

20

Small-scale

0.968

High

181628

CFLAR
CASP8 and FADD-like apoptosis regulator

5

18

Small-scale

0.932

High

957749

XIAP
E3 ubiquitin-protein ligase XIAP

3

20

Small-scale

0.883

High

1271826

CASPA
Caspase-10

3

20

Small-scale

0.865

High

788219

CASP3
Caspase-3

2

17

Small-scale

0.778

High

1271828

M3K14
Mitogen-activated protein kinase kinase kinase 14

2

7

Small-scale

0.776

High

632343

TNR6
Tumor necrosis factor receptor superfamily member 6

4

16

Small-scale

0.666

High

1263648

DEDD2
DNA-binding death effector domain-containing protein 2

1

5

Small-scale

0.665

High

667482

CASP1
Caspase-1

1

17

Small-scale

0.647

High

788259

CASP2
Caspase-2

1

20

Small-scale

0.647

High

830289

CASP4
Caspase-4

1

17

Small-scale

0.647

High

876959

CASP7
Caspase-7

1

19

Small-scale

0.647

High

876994

CASP9
Caspase-9

1

20

Small-scale

0.647

High

877112

CASP6
Caspase-6

1

17

Small-scale

0.647

High

152975

RIOK3
Serine/threonine-protein kinase RIO3

2

0

Small-scale

0.634

High

271707

DEDD
Death effector domain-containing protein

1

5

Small-scale

0.618

High

683121

CASPE
Caspase-14

1

17

Small-scale

0.618

High

1035946

BIRC3
Baculoviral IAP repeat-containing protein 3

1

20

Small-scale

0.618

High

1036308

BIRC2
Baculoviral IAP repeat-containing protein 2

1

20

Small-scale

0.618

High

486168

GRAB
Granzyme B

2

11

Small-scale

0.602

High

1038295

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

8

Small-scale

0.601

High

1271833

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.584

High

670746

PRDX6
Peroxiredoxin-6

1

1

Small-scale

0.582

High

800815

MK08
Mitogen-activated protein kinase 8

1

11

Small-scale

0.575

High

121517

TR10A
Tumor necrosis factor receptor superfamily member 10A

2

16

Small-scale

0.571

High

154397

TR10B
Tumor necrosis factor receptor superfamily member 10B

2

16

Small-scale

0.571

High

584446

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

16

Small-scale

0.571

High

815704

TNFL6
Tumor necrosis factor ligand superfamily member 6

2

13

Small-scale

0.571

High

1271827

RNF34
E3 ubiquitin-protein ligase RNF34

1

20

Small-scale

0.552

High

1271831

BCLF1
Bcl-2-associated transcription factor 1

1

2

Small-scale

0.515

High

1271834

C8AP2
CASP8-associated protein 2

1

1

Small-scale

0.508

High

414347

RB
Retinoblastoma-associated protein

1

5

Small-scale

0.501

High

1023744

TRAF1
TNF receptor-associated factor 1

1

18

Small-scale

0.501

High

131027

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

839536

SPB9
Serpin B9

1

8

Small-scale

0.479

High

1233134

RYBP
RING1 and YY1-binding protein

1

1

Small-scale

0.479

High

1271829

TNR27
Tumor necrosis factor receptor superfamily member 27

1

1

Small-scale

0.479

High

1271830

IFT57
Intraflagellar transport protein 57 homolog

1

2

Small-scale

0.479

High

1271832

BFAR
Bifunctional apoptosis regulator

1

8

Small-scale

0.479

High

547166

EZRI
Ezrin

1

4

Small-scale

0.445

High

640137

MOES
Moesin

1

4

Small-scale

0.445

High

841079

TNF10
Tumor necrosis factor ligand superfamily member 10

1

13

Small-scale

0.445

High

854814

GDIR1
Rho GDP-dissociation inhibitor 1

1

8

Small-scale

0.445

High

879539

BID
BH3-interacting domain death agonist

1

4

Small-scale

0.445

High

900764

RHOA
Transforming protein RhoA

1

3

Small-scale

0.445

High

1271835

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.437

High

68303

P20L1
PHD finger protein 20-like protein 1

1

0

High-throughput

0.282

High

204400

MS18B
Protein Mis18-beta

1

0

High-throughput

0.282

High

600637

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024