Protein: ZNRF4
E3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (Nixin) (RING finger protein 204) (RING-type E3 ubiquitin transferase ZNRF4) (Zinc/RING finger protein 4)

Gene: ZNRF4
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q8WWF5

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

924365

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

7

High-throughput

0.811

High

1262541

AMFR
E3 ubiquitin-protein ligase AMFR

2

14

High-throughput

0.811

High

849385

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

High-throughput

0.698

High

851856

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

891420

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

High-throughput

0.698

High

895860

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

High-throughput

0.698

High

896503

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

High-throughput

0.698

High

919802

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

High-throughput

0.698

High

1262513

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1262545

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

1032793

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

3

1

High-throughput

0.667

High

1128968

S27A3
Long-chain fatty acid transport protein 3

3

7

High-throughput

0.667

High

1221523

PLPL6
Patatin-like phospholipase domain-containing protein 6

3

0

High-throughput

0.638

High

1262514

ASTRA
Protein Aster-A

3

0

High-throughput

0.638

High

165290

AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

2

6

High-throughput

0.628

High

200752

ADCY6
Adenylate cyclase type 6

2

2

High-throughput

0.628

High

233078

FZD6
Frizzled-6

2

6

High-throughput

0.628

High

265543

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

2

3

High-throughput

0.628

High

299696

SUN1
SUN domain-containing protein 1

2

1

High-throughput

0.628

High

303931

YIF1A
Protein YIF1A

2

1

High-throughput

0.628

High

315039

SGPL1
Sphingosine-1-phosphate lyase 1

2

1

High-throughput

0.628

High

603077

OSBP1
Oxysterol-binding protein 1

2

3

High-throughput

0.628

High

741155

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

2

1

High-throughput

0.628

High

1016006

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

2

12

High-throughput

0.628

High

1016088

SRBP2
Sterol regulatory element-binding protein 2

2

1

High-throughput

0.628

High

1021934

SEC20
Vesicle transport protein SEC20

2

1

High-throughput

0.628

High

1055690

ITPR2
Inositol 1,4,5-trisphosphate receptor type 2

2

1

High-throughput

0.628

High

1117479

ANO6
Anoctamin-6

2

1

High-throughput

0.628

High

1205039

VRK2
Serine/threonine-protein kinase VRK2

2

7

High-throughput

0.628

High

1243336

PDZD8
PDZ domain-containing protein 8

2

1

High-throughput

0.628

High

1257004

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

2

7

High-throughput

0.628

High

1262516

P121A
Nuclear envelope pore membrane protein POM 121

2

5

High-throughput

0.628

High

1262523

NDC1
Nucleoporin NDC1

2

3

High-throughput

0.628

High

1262526

OSBL8
Oxysterol-binding protein-related protein 8

2

3

High-throughput

0.628

High

1262528

DJC18
DnaJ homolog subfamily C member 18

2

9

High-throughput

0.628

High

1262532

ZDH18
Palmitoyltransferase ZDHHC18

2

6

High-throughput

0.628

High

1262534

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

2

3

High-throughput

0.628

High

1262538

NB5R1
NADH-cytochrome b5 reductase 1

2

4

High-throughput

0.628

High

1262539

S12A6
Solute carrier family 12 member 6

2

6

High-throughput

0.628

High

1262543

S27A6
Long-chain fatty acid transport protein 6

2

6

High-throughput

0.628

High

1262546

TMX2
Thioredoxin-related transmembrane protein 2

2

2

High-throughput

0.628

High

1262547

ZDHC9
Palmitoyltransferase ZDHHC9

2

6

High-throughput

0.628

High

1262512

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.625

High

1259698

RN139
E3 ubiquitin-protein ligase RNF139

1

19

High-throughput

0.618

High

1138709

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

2

4

High-throughput

0.611

High

146997

C2C2L
Phospholipid transfer protein C2CD2L

2

0

High-throughput

0.602

High

245507

NSMA
Sphingomyelin phosphodiesterase 2

2

0

High-throughput

0.602

High

1055236

ERG1
Squalene monooxygenase

2

0

High-throughput

0.602

High

1204442

FBX11
F-box only protein 11

2

0

High-throughput

0.602

High

1262519

CGRF1
Cell growth regulator with RING finger domain protein 1

2

0

High-throughput

0.602

High

1262548

DGLA
Diacylglycerol lipase-alpha

2

0

High-throughput

0.602

High

69489

UPK3L
Uroplakin-3b-like protein 1

2

1

High-throughput

0.574

High

1165046

KCNT2
Potassium channel subfamily T member 2

2

1

High-throughput

0.574

High

1255496

ST7L
Suppressor of tumorigenicity 7 protein-like

2

1

High-throughput

0.574

High

1261842

BT2A2
Butyrophilin subfamily 2 member A2

2

5

High-throughput

0.574

High

1262511

PTPRU
Receptor-type tyrosine-protein phosphatase U

2

6

High-throughput

0.574

High

1262521

ABCA3
Phospholipid-transporting ATPase ABCA3

2

3

High-throughput

0.574

High

1262525

ABCA2
ATP-binding cassette sub-family A member 2

2

2

High-throughput

0.574

High

1262527

PCX3
Pecanex-like protein 3

2

1

High-throughput

0.574

High

1262537

SUN2
SUN domain-containing protein 2

2

1

High-throughput

0.574

High

1262540

KCNG1
Potassium voltage-gated channel subfamily G member 1

2

2

High-throughput

0.574

High

1262542

VANG2
Vang-like protein 2

2

2

High-throughput

0.574

High

1262544

MAN1
Inner nuclear membrane protein Man1

2

4

High-throughput

0.574

High

1262549

LRP12
Low-density lipoprotein receptor-related protein 12

2

2

High-throughput

0.574

High

1262550

SNX14
Sorting nexin-14

2

4

High-throughput

0.574

High

1262551

S12A7
Solute carrier family 12 member 7

2

5

High-throughput

0.574

High

201818

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

2

Small-scale

0.561

High

599808

5NTD
5'-nucleotidase

2

2

High-throughput

0.553

High

1237239

TPRX1
Tetra-peptide repeat homeobox protein 1

2

2

High-throughput

0.553

High

1044930

AVR2B
Activin receptor type-2B

1

11

High-throughput

0.536

High

1055762

ITPR3
Inositol 1,4,5-trisphosphate receptor type 3

1

1

High-throughput

0.536

High

1131929

PR15B
Protein phosphatase 1 regulatory subunit 15B

2

0

High-throughput

0.528

High

1262515

NGBR
Dehydrodolichyl diphosphate synthase complex subunit NUS1

1

0

High-throughput

0.513

High

1262517

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

0

High-throughput

0.513

High

1262533

TM39A
Transmembrane protein 39A

1

0

High-throughput

0.513

High

360216

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

4

High-throughput

0.489

High

1164446

SAMD1
Sterile alpha motif domain-containing protein 1

1

2

High-throughput

0.489

High

1182901

BT2A1
Butyrophilin subfamily 2 member A1

1

5

High-throughput

0.489

High

1262530

AT132
Polyamine-transporting ATPase 13A2

1

10

High-throughput

0.489

High

1262531

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.489

High

118380

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.479

High

161557

S27A2
Long-chain fatty acid transport protein 2

1

6

High-throughput

0.479

High

258126

DNJB6
DnaJ homolog subfamily B member 6

1

7

High-throughput

0.479

High

373142

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

11

High-throughput

0.479

High

421340

HYEP
Epoxide hydrolase 1

1

1

High-throughput

0.479

High

502365

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.479

High

654604

CALX
Calnexin

1

5

Small-scale

0.479

High

854245

DGKE
Diacylglycerol kinase epsilon

1

1

High-throughput

0.479

High

1069140

PON2
Serum paraoxonase/arylesterase 2

1

4

High-throughput

0.479

High

1262518

SDF2
Stromal cell-derived factor 2

1

6

High-throughput

0.479

High

1262520

SGMR1
Sigma non-opioid intracellular receptor 1

1

1

High-throughput

0.479

High

1262522

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

5

High-throughput

0.479

High

1262529

SDF2L
Stromal cell-derived factor 2-like protein 1

1

6

High-throughput

0.479

High

1262536

DJB11
DnaJ homolog subfamily B member 11

1

8

High-throughput

0.479

High

1078330

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.458

High

1262535

SAE1
SUMO-activating enzyme subunit 1

1

0

High-throughput

0.458

High

120007

AP3B1
AP-3 complex subunit beta-1

1

4

High-throughput

0.437

High

431257

CATB
Cathepsin B

1

2

High-throughput

0.437

High

676695

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

2

High-throughput

0.437

High

1080165

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

1223547

K2013
Uncharacterized protein KIAA2013

1

1

High-throughput

0.437

High

300358

AGRL1
Adhesion G protein-coupled receptor L1

2

0

High-throughput

0.328

High

946420

EREP3
Protein ENTREP3

2

0

High-throughput

0.328

High

1137987

MARC1
Mitochondrial amidoxime-reducing component 1

2

0

High-throughput

0.328

High

1191362

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

2

0

High-throughput

0.328

High

1241164

NETO2
Neuropilin and tolloid-like protein 2

2

0

High-throughput

0.328

High

1262524

CA043
Protein C1orf43

2

0

High-throughput

0.328

High

131936

UPK2
Uroplakin-2

2

0

High-throughput

0.316

High

822495

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024