Protein: DEFI6
Differentially expressed in FDCP 6 homolog (DEF-6) (IRF4-binding protein)

Gene: DEFI6, DEF6
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q9H4E7

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

65916

RHG42
Rho GTPase-activating protein 42

3

11

High-throughput

0.861

High

1048293

KPCT
Protein kinase C theta type

3

15

High-throughput

0.861

High

116832

I6L996
Focal adhesion kinase-related nonkinase

2

20

High-throughput

0.789

High

1279149

RHG22
Rho GTPase-activating protein 22

2

19

High-throughput

0.783

High

1051056

FAK1
Focal adhesion kinase 1

2

20

High-throughput

0.754

High

1311784

HOMEZ
Homeobox and leucine zipper protein Homez

5

3

High-throughput

0.723

High

703379

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

3

7

High-throughput

0.667

High

774172

ADDB
Beta-adducin

3

2

High-throughput

0.667

High

858808

BRCC3
Lys-63-specific deubiquitinase BRCC36

3

5

High-throughput

0.667

High

1026776

NFKB2
Nuclear factor NF-kappa-B p100 subunit

3

20

High-throughput

0.667

High

1278850

DCXR
L-xylulose reductase

3

1

High-throughput

0.667

High

1307521

RBM45
RNA-binding protein 45

3

3

High-throughput

0.667

High

1366033

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

3

19

High-throughput

0.667

High

1395206

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

3

8

High-throughput

0.667

High

1433619

GRID1
Glutamate receptor ionotropic, delta-1

3

8

High-throughput

0.667

High

581288

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

Small-scale

0.647

High

955592

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.647

High

962480

RHOA
Transforming protein RhoA

1

20

Small-scale

0.647

High

988704

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.647

High

1136945

ABRX2
BRISC complex subunit Abraxas 2

3

0

High-throughput

0.638

High

1329576

CA052
UPF0690 protein C1orf52

3

0

High-throughput

0.638

High

1433613

BABA1
BRISC and BRCA1-A complex member 1

3

0

High-throughput

0.638

High

1433614

DCA16
DDB1- and CUL4-associated factor 16

3

0

High-throughput

0.638

High

1433615

BABA2
BRISC and BRCA1-A complex member 2

3

0

High-throughput

0.638

High

1433611

TNR6C
Trinucleotide repeat-containing gene 6C protein

2

17

High-throughput

0.628

High

587214

ITF2
Transcription factor 4

2

1

High-throughput

0.628

High

1227455

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.618

High

64554

CC88B
Coiled-coil domain-containing protein 88B

2

15

High-throughput

0.606

High

505770

ZN688
Zinc finger protein 688

2

1

High-throughput

0.606

High

681028

PSA1
Proteasome subunit alpha type-1

2

3

High-throughput

0.606

High

1048998

REL
Proto-oncogene c-Rel

2

9

High-throughput

0.606

High

1146162

K1H1
Keratin, type I cuticular Ha1

2

20

High-throughput

0.606

High

1295618

RASL3
RAS protein activator like-3

2

13

High-throughput

0.606

High

1362105

RPGF4
Rap guanine nucleotide exchange factor 4

2

12

High-throughput

0.606

High

1395249

LMBL3
Lethal(3)malignant brain tumor-like protein 3

2

2

High-throughput

0.606

High

134867

SAP18
Histone deacetylase complex subunit SAP18

2

0

High-throughput

0.580

High

335508

SLU7
Pre-mRNA-splicing factor SLU7

2

0

High-throughput

0.580

High

1081481

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1398710

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.580

High

1430041

INT2
Integrator complex subunit 2

2

0

High-throughput

0.580

High

180592

PLS1
Phospholipid scramblase 1

1

1

High-throughput

0.573

High

1383471

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

15

High-throughput

0.573

High

1433612

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.573

High

65164

GG6L9
Golgin subfamily A member 6-like protein 9

2

20

High-throughput

0.553

High

1287060

K1328
Protein hinderin

2

2

High-throughput

0.553

High

1433616

GOG6A
Golgin subfamily A member 6A

2

19

High-throughput

0.553

High

1025846

BORG5
Cdc42 effector protein 1

1

0

High-throughput

0.549

High

1247808

KLH24
Kelch-like protein 24

1

7

High-throughput

0.536

High

1433617

RCC2
Protein RCC2

1

5

High-throughput

0.536

High

1414261

BEGIN
Brain-enriched guanylate kinase-associated protein

1

0

High-throughput

0.518

High

423161

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

288019

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

6

High-throughput

0.479

High

1290303

KBTB6
Kelch repeat and BTB domain-containing protein 6

1

10

High-throughput

0.479

High

1433618

ZRAN1
Ubiquitin thioesterase ZRANB1

1

19

High-throughput

0.479

High

1279233

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

1333332

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1390537

CDCA5
Sororin

1

0

High-throughput

0.458

High

1145840

IRF4
Interferon regulatory factor 4

1

3

Small-scale

0.457

High


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Last updated: 11Aug2025