Protein: SYTM
Threonine--tRNA ligase, mitochondrial (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) (Threonyl-tRNA synthetase-like 1)

Gene: SYTM, TARS2
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q9BW92

Gene Ontology (top 5):
GO:0002161 - aminoacyl-tRNA editing activity
GO:0004829 - threonine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005759 - mitochondrial matrix
GO:0006435 - threonyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

58247

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

11

High-throughput

0.783

High

1128237

SYAM
Alanine--tRNA ligase, mitochondrial

1

4

High-throughput

0.618

High

1314528

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.618

High

262945

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

1086770

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

1042448

CUL3
Cullin-3

2

6

High-throughput

0.558

High

1314521

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

2

2

High-throughput

0.553

High

1314536

ASB6
Ankyrin repeat and SOCS box protein 6

2

1

High-throughput

0.553

High

1314553

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

2

High-throughput

0.553

High

258781

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

529677

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

646451

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

1030121

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

High-throughput

0.536

High

1051072

ICT1
Large ribosomal subunit protein mL62

1

2

High-throughput

0.536

High

1233872

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

1

High-throughput

0.536

High

1314522

LDH6B
L-lactate dehydrogenase A-like 6B

1

1

High-throughput

0.536

High

1314525

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

1

High-throughput

0.536

High

1314550

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1314551

RT02
Small ribosomal subunit protein uS2m

1

3

High-throughput

0.536

High

228565

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.533

High

272385

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

1156327

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

1159927

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

1314519

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

1

0

High-throughput

0.513

High

1314544

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.513

High

270941

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

1

High-throughput

0.489

High

314384

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

1

High-throughput

0.489

High

488361

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.489

High

815429

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.489

High

957131

SHC2
SHC-transforming protein 2

1

3

High-throughput

0.489

High

1020144

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

1

High-throughput

0.489

High

1218962

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

4

High-throughput

0.489

High

1285824

TRI43
Tripartite motif-containing protein 43

1

1

High-throughput

0.489

High

1289870

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.489

High

1301889

RSLAB
Ras-like protein family member 10B

1

1

High-throughput

0.489

High

1310794

WDR83
WD repeat domain-containing protein 83

1

3

High-throughput

0.489

High

1310966

NPS3B
Protein NipSnap homolog 3B

1

2

High-throughput

0.489

High

1314526

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

1

High-throughput

0.489

High

1314532

RT30
Large ribosomal subunit protein mL65

1

1

High-throughput

0.489

High

1314541

NPS3A
Protein NipSnap homolog 3A

1

2

High-throughput

0.489

High

1314546

FKBPL
FK506-binding protein-like

1

3

High-throughput

0.489

High

1314549

GPR55
G-protein coupled receptor 55

1

2

High-throughput

0.489

High

243585

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.479

High

295215

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

338932

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

385456

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

500068

CH60
60 kDa heat shock protein, mitochondrial

1

5

High-throughput

0.479

High

828016

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

3

High-throughput

0.479

High

909060

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

981400

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1020541

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

High-throughput

0.479

High

1045846

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1051911

IF4A2
Eukaryotic initiation factor 4A-II

1

2

High-throughput

0.479

High

1068067

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

1288979

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

1300379

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.479

High

1314531

MET17
Ribosome assembly protein METTL17, mitochondrial

1

2

High-throughput

0.479

High

1314534

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

3

High-throughput

0.479

High

1314538

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1314542

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

4

High-throughput

0.479

High

118433

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

258520

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

411839

LCK
Tyrosine-protein kinase Lck

1

0

High-throughput

0.458

High

440706

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

1262384

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1062266

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

3

Small-scale

0.445

High

1130541

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

5

High-throughput

0.445

High

1220203

HOMEZ
Homeobox and leucine zipper protein Homez

1

1

High-throughput

0.439

High

173103

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.437

High

304319

UBR5
E3 ubiquitin-protein ligase UBR5

1

4

Small-scale

0.437

High

323082

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.437

High

325366

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.437

High

442454

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.437

High

553614

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

719108

PHB1
Prohibitin 1

1

2

High-throughput

0.437

High

721337

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

780036

CCNF
Cyclin-F

1

4

High-throughput

0.437

High

803215

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.437

High

827557

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.437

High

951286

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

1036036

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.437

High

1165924

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

1171536

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1188809

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

1269515

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

1293968

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

1305081

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.437

High

1310115

LZTS2
Leucine zipper putative tumor suppressor 2

1

1

High-throughput

0.437

High

1310850

TRI56
E3 ubiquitin-protein ligase TRIM56

1

2

High-throughput

0.437

High

1314518

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.437

High

1314520

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

1314523

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

5

High-throughput

0.437

High

1314527

MTRFR
Mitochondrial translation release factor in rescue

1

4

High-throughput

0.437

High

1314529

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

1314530

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

1314543

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1314547

ANC2
Anaphase-promoting complex subunit 2

1

7

High-throughput

0.437

High

1125

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

402431

JUN
Transcription factor Jun

1

8

High-throughput

0.407

High

1241602

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

238197

PLIN3
Perilipin-3

2

0

High-throughput

0.316

High

1065308

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

2

0

High-throughput

0.316

High

1083206

SYPL1
Synaptophysin-like protein 1

2

0

High-throughput

0.316

High

1314539

TR10D
Tumor necrosis factor receptor superfamily member 10D

2

0

High-throughput

0.316

High

172207

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

207267

TNF14
Tumor necrosis factor ligand superfamily member 14

1

0

High-throughput

0.279

Low

341462

FA12
Coagulation factor XII

1

0

High-throughput

0.279

Low

1082958

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.279

Low

1202725

P2RY8
P2Y purinoceptor 8

1

0

High-throughput

0.279

Low

1307328

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

0

High-throughput

0.279

Low

1309932

LSMD1
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.279

Low

1312686

MYL10
Myosin regulatory light chain 10

1

0

High-throughput

0.279

Low

1314533

CT096
Uncharacterized protein C20orf96

1

0

High-throughput

0.279

Low

1314540

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.279

Low

1314545

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.279

Low

1314548

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.279

Low

1314552

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

1260984

SFT2A
Vesicle transport protein SFT2A

1

0

High-throughput

0.268

Low

1281654

MAL2
Protein MAL2

1

0

High-throughput

0.268

Low

1287652

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.268

Low

262561

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

473413

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.249

Low

525624

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.249

Low

644316

TTP
mRNA decay activator protein ZFP36

1

0

High-throughput

0.249

Low

781977

PERI
Peripherin

1

0

High-throughput

0.249

Low

1053647

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1152075

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1168828

MEX3B
RNA-binding protein MEX3B

1

0

High-throughput

0.249

Low

1239318

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1268902

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.249

Low

1284518

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.249

Low

1313630

LRC61
Leucine-rich repeat-containing protein 61

1

0

High-throughput

0.249

Low

1314524

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1314535

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.249

Low

1314537

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.249

Low

275467

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.232

Low

563795

ZNF3
Zinc finger protein 3

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024