Protein: KDM2B
Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B)

Gene: KDM2B
Organism: Homo sapiens
Interactions: 146
UniProt ID: Q8NHM5

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 - DNA binding
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

928997

SKP1
S-phase kinase-associated protein 1

13

20

Small-scale

0.981

High

1245590

PCGF1
Polycomb group RING finger protein 1

12

20

Small-scale

0.760

High

1041100

CUL1
Cullin-1

2

20

Small-scale

0.754

High

1167276

BCOR
BCL-6 corepressor

8

6

Small-scale

0.752

High

1233111

RYBP
RING1 and YY1-binding protein

8

4

Small-scale

0.750

High

1245587

RING2
E3 ubiquitin-protein ligase RING2

8

20

Small-scale

0.749

High

1222195

YAF2
YY1-associated factor 2

6

4

High-throughput

0.733

High

935008

H31
Histone H3.1

4

20

Small-scale

0.692

High

1245577

KDM2B
Lysine-specific demethylase 2B

1

5

Small-scale

0.647

High

987996

RING1
E3 ubiquitin-protein ligase RING1

2

20

High-throughput

0.628

High

345494

FOS
Protein c-Fos

2

4

Small-scale

0.624

High

1245585

PF21A
PHD finger protein 21A

1

6

High-throughput

0.618

High

316106

CBX6
Chromobox protein homolog 6

2

10

High-throughput

0.611

High

921349

RBX1
E3 ubiquitin-protein ligase RBX1

2

5

Small-scale

0.611

High

1245600

CBX8
Chromobox protein homolog 8

2

10

High-throughput

0.611

High

347381

MYC
Myc proto-oncogene protein

2

7

High-throughput

0.584

High

818272

SOX2
Transcription factor SOX-2

2

7

Small-scale

0.584

High

1032517

CTBP1
C-terminal-binding protein 1

2

4

High-throughput

0.584

High

1108521

PCGF3
Polycomb group RING finger protein 3

2

20

High-throughput

0.584

High

1245581

CBP
CREB-binding protein

1

12

Small-scale

0.578

High

370049

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

1245582

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.561

High

1077830

CEBPE
CCAAT/enhancer-binding protein epsilon

1

2

High-throughput

0.541

High

123291

CBX4
E3 SUMO-protein ligase CBX4

1

10

High-throughput

0.536

High

380814

S100B
Protein S100-B

1

3

High-throughput

0.536

High

555555

H2AX
Histone H2AX

1

7

High-throughput

0.536

High

1125890

BCORL
BCL-6 corepressor-like protein 1

1

5

High-throughput

0.536

High

1174601

H32
Histone H3.2

1

20

High-throughput

0.536

High

1245593

RTF2
Replication termination factor 2

1

1

High-throughput

0.536

High

995065

GOGA2
Golgin subfamily A member 2

2

1

High-throughput

0.533

High

1027140

CBX3
Chromobox protein homolog 3

1

10

High-throughput

0.515

High

1224855

FAM9B
Protein FAM9B

1

0

High-throughput

0.513

High

849376

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

3

Small-scale

0.501

High

1235438

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

13

High-throughput

0.494

High

851607

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.489

High

124020

SPT5H
Transcription elongation factor SPT5

1

8

High-throughput

0.479

High

135136

NFIB
Nuclear factor 1 B-type

1

4

High-throughput

0.479

High

171054

TBXT
T-box transcription factor T

1

3

High-throughput

0.479

High

179731

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.479

High

197769

CRX
Cone-rod homeobox protein

1

8

High-throughput

0.479

High

204198

KLF4
Krueppel-like factor 4

1

10

High-throughput

0.479

High

211922

TLX3
T-cell leukemia homeobox protein 3

1

8

High-throughput

0.479

High

213360

TLX2
T-cell leukemia homeobox protein 2

1

4

High-throughput

0.479

High

232345

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.479

High

265686

E2F6
Transcription factor E2F6

1

6

High-throughput

0.479

High

271777

PRDM1
PR domain zinc finger protein 1

1

1

High-throughput

0.479

High

316942

KLF8
Krueppel-like factor 8

1

10

High-throughput

0.479

High

377510

GCR
Glucocorticoid receptor

1

17

High-throughput

0.479

High

387145

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

402263

JUN
Transcription factor Jun

1

2

Small-scale

0.479

High

443218

NFIC
Nuclear factor 1 C-type

1

8

High-throughput

0.479

High

455671

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

485076

GLI2
Zinc finger protein GLI2

1

2

High-throughput

0.479

High

485136

GLI3
Transcriptional activator GLI3

1

2

High-throughput

0.479

High

486813

MYB
Transcriptional activator Myb

1

3

High-throughput

0.479

High

487601

ANDR
Androgen receptor

1

15

High-throughput

0.479

High

507470

ERG
Transcriptional regulator ERG

1

15

High-throughput

0.479

High

510029

ERR1
Steroid hormone receptor ERR1

1

14

Small-scale

0.479

High

542043

ETS1
Protein C-ets-1

1

16

High-throughput

0.479

High

546010

MYOD1
Myoblast determination protein 1

1

4

High-throughput

0.479

High

554482

GATA1
Erythroid transcription factor

1

2

High-throughput

0.479

High

586871

CSK22
Casein kinase II subunit alpha'

1

9

High-throughput

0.479

High

595942

HNF1A
Hepatocyte nuclear factor 1-alpha

1

5

High-throughput

0.479

High

620177

PAX7
Paired box protein Pax-7

1

8

High-throughput

0.479

High

620387

GATA2
Endothelial transcription factor GATA-2

1

2

High-throughput

0.479

High

620535

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

2

High-throughput

0.479

High

641484

PAX6
Paired box protein Pax-6

1

6

High-throughput

0.479

High

658535

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

679139

TLX1
T-cell leukemia homeobox protein 1

1

5

High-throughput

0.479

High

718034

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.479

High

718413

PCGF2
Polycomb group RING finger protein 2

1

20

High-throughput

0.479

High

727563

HNF1B
Hepatocyte nuclear factor 1-beta

1

9

High-throughput

0.479

High

727778

SOX5
Transcription factor SOX-5

1

5

High-throughput

0.479

High

727897

SOX6
Transcription factor SOX-6

1

6

High-throughput

0.479

High

740559

PPARG
Peroxisome proliferator-activated receptor gamma

1

16

High-throughput

0.479

High

750362

COIL
Coilin

1

2

High-throughput

0.479

High

781400

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.479

High

782597

HNF4A
Hepatocyte nuclear factor 4-alpha

1

14

High-throughput

0.479

High

785386

ELK3
ETS domain-containing protein Elk-3

1

15

High-throughput

0.479

High

794555

ETV4
ETS translocation variant 4

1

15

High-throughput

0.479

High

808783

YAP1
Transcriptional coactivator YAP1

1

7

High-throughput

0.479

High

818821

SOX9
Transcription factor SOX-9

1

6

High-throughput

0.479

High

822652

LHX1
LIM/homeobox protein Lhx1

1

5

High-throughput

0.479

High

828308

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

839787

LHX2
LIM/homeobox protein Lhx2

1

5

High-throughput

0.479

High

861851

PLK1
Serine/threonine-protein kinase PLK1

1

1

Small-scale

0.479

High

878443

PAX9
Paired box protein Pax-9

1

6

High-throughput

0.479

High

882144

GSC
Homeobox protein goosecoid

1

4

High-throughput

0.479

High

884207

KLF3
Krueppel-like factor 3

1

12

High-throughput

0.479

High

917624

H4
Histone H4

1

5

High-throughput

0.479

High

918535

H2B1C
Histone H2B type 1-C/E/F/G/I

1

6

High-throughput

0.479

High

943079

PHC1
Polyhomeotic-like protein 1

1

9

High-throughput

0.479

High

952482

H33
Histone H3.3

1

20

High-throughput

0.479

High

967924

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.479

High

973868

PAX2
Paired box protein Pax-2

1

6

High-throughput

0.479

High

985240

HME1
Homeobox protein engrailed-1

1

1

High-throughput

0.479

High

988785

PAX8
Paired box protein Pax-8

1

7

High-throughput

0.479

High

1018243

NFIA
Nuclear factor 1 A-type

1

8

High-throughput

0.479

High

1021237

FOXI1
Forkhead box protein I1

1

4

High-throughput

0.479

High

1021324

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.479

High

1046717

KLF5
Krueppel-like factor 5

1

10

High-throughput

0.479

High

1059178

CBX2
Chromobox protein homolog 2

1

10

High-throughput

0.479

High

1060332

NFIX
Nuclear factor 1 X-type

1

8

High-throughput

0.479

High

1071058

IRF4
Interferon regulatory factor 4

1

1

High-throughput

0.479

High

1080136

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

Small-scale

0.479

High

1085163

TBR1
T-box brain protein 1

1

3

High-throughput

0.479

High

1101571

ISX
Intestine-specific homeobox

1

6

High-throughput

0.479

High

1139404

ECM29
Proteasome adapter and scaffold protein ECM29

1

4

Small-scale

0.479

High

1188585

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1197574

PCGF5
Polycomb group RING finger protein 5

1

20

High-throughput

0.479

High

1218688

MGAP
MAX gene-associated protein

1

2

High-throughput

0.479

High

1220858

PHC2
Polyhomeotic-like protein 2

1

4

High-throughput

0.479

High

1242723

PHC3
Polyhomeotic-like protein 3

1

10

High-throughput

0.479

High

1245578

SP7
Transcription factor Sp7

1

8

High-throughput

0.479

High

1245580

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1245583

LHX4
LIM/homeobox protein Lhx4

1

5

High-throughput

0.479

High

1245584

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

1

High-throughput

0.479

High

1245588

FEV
Protein FEV

1

14

High-throughput

0.479

High

1245589

ELF4
ETS-related transcription factor Elf-4

1

16

High-throughput

0.479

High

1245591

SOX7
Transcription factor SOX-7

1

6

High-throughput

0.479

High

1245592

KLF16
Krueppel-like factor 16

1

8

High-throughput

0.479

High

1245594

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.479

High

1245595

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.479

High

1245596

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

3

High-throughput

0.479

High

1245597

SOX17
Transcription factor SOX-17

1

6

High-throughput

0.479

High

1245598

NANOG
Homeobox protein NANOG

1

4

High-throughput

0.479

High

1245604

VSX1
Visual system homeobox 1

1

9

High-throughput

0.479

High

1245605

LHX3
LIM/homeobox protein Lhx3

1

5

High-throughput

0.479

High

1245606

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1245607

KLF15
Krueppel-like factor 15

1

9

High-throughput

0.479

High

1245608

RCOR1
REST corepressor 1

1

3

High-throughput

0.479

High

1245609

LHX6
LIM/homeobox protein Lhx6

1

5

High-throughput

0.479

High

1245610

ZN330
Zinc finger protein 330

1

3

High-throughput

0.479

High

1245611

KLF12
Krueppel-like factor 12

1

11

High-throughput

0.479

High

1245612

ETV7
Transcription factor ETV7

1

16

High-throughput

0.479

High

505262

EGR2
E3 SUMO-protein ligase EGR2

1

0

High-throughput

0.458

High

961202

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1038550

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1081816

SSX1
Protein SSX1

1

0

Small-scale

0.458

High

1245579

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1245586

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

1245601

GCM1
Chorion-specific transcription factor GCMa

1

0

High-throughput

0.458

High

1245603

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1245602

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

5

High-throughput

0.437

High

1245599

FBRS
Probable fibrosin-1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024