Protein: ERCC1
DNA excision repair protein ERCC-1

Gene: ERCC1
Organism: Homo sapiens
Interactions: 55
UniProt ID: P07992

Gene Ontology (top 5):
GO:0000109 - nucleotide-excision repair complex
GO:0000110 - nucleotide-excision repair factor 1 complex
GO:0000720 - pyrimidine dimer repair by nucleotide-excision repair
GO:0000781 - chromosome, telomeric region
GO:0001094 - TFIID-class transcription factor complex binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

434589

XPF
DNA repair endonuclease XPF

28

4

Small-scale

0.993

High

434561

XPA
DNA repair protein complementing XP-A cells

18

2

Small-scale

0.766

High

434586

SLX4
Structure-specific endonuclease subunit SLX4

15

2

Small-scale

0.761

High

434592

MUS81
Crossover junction endonuclease MUS81

2

0

Small-scale

0.748

High

434593

UBL7
Ubiquitin-like protein 7

3

0

High-throughput

0.661

High

434596

SLX1
Structure-specific endonuclease subunit SLX1

3

0

Small-scale

0.642

High

434585

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

2

1

Small-scale

0.633

High

434556

ERCC1
DNA excision repair protein ERCC-1

1

1

Small-scale

0.618

High

434598

VP37B
Vacuolar protein sorting-associated protein 37B

2

0

High-throughput

0.601

High

434588

USBP1
Harmonin-binding protein USHBP1

1

0

High-throughput

0.549

High

434568

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.537

High

434594

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

0

Small-scale

0.537

High

434570

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.536

High

174343

FANCG
Fanconi anemia group G protein

1

0

Small-scale

0.529

High

434578

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

1

High-throughput

0.523

High

283286

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

1

0

High-throughput

0.518

High

125836

CDC7
Cell division cycle 7-related protein kinase

1

0

High-throughput

0.513

High

337792

EGFR
Epidermal growth factor receptor

1

0

Small-scale

0.513

High

416554

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

434571

IMA5
Importin subunit alpha-5

1

0

High-throughput

0.513

High

434573

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.513

High

434595

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

282488

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

Small-scale

0.500

High

393949

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

434558

RFA2
Replication protein A 32 kDa subunit

1

0

Small-scale

0.480

High

434563

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.480

High

434565

RFA3
Replication protein A 14 kDa subunit

1

0

Small-scale

0.480

High

434567

MSH2
DNA mismatch repair protein Msh2

1

2

Small-scale

0.479

High

434576

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

434580

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

434584

Q6NSB6
MKRN3 protein

1

1

High-throughput

0.470

High

434559

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

434560

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

434562

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

434564

TF2H1
General transcription factor IIH subunit 1

1

0

Small-scale

0.458

High

434566

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

434569

TAF6
Transcription initiation factor TFIID subunit 6

1

0

Small-scale

0.458

High

434574

DCAF7
DDB1- and CUL4-associated factor 7

1

0

Small-scale

0.458

High

434575

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

434577

TAF10
Transcription initiation factor TFIID subunit 10

1

0

Small-scale

0.458

High

434579

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.458

High

434581

TAF7
Transcription initiation factor TFIID subunit 7

1

0

Small-scale

0.458

High

434582

TAF12
Transcription initiation factor TFIID subunit 12

1

0

Small-scale

0.458

High

434587

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

434599

CASS4
Cas scaffolding protein family member 4

1

0

High-throughput

0.438

High

434597

MAGIX
PDZ domain-containing protein MAGIX

3

0

High-throughput

0.347

High

434583

SLX4I
Protein SLX4IP

3

0

Small-scale

0.342

High

330053

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.316

High

434591

TRM2B
tRNA

1

0

High-throughput

0.299

High

434572

KIF11
Kinesin-like protein KIF11

1

0

Small-scale

0.292

High

434557

ACM5
Muscarinic acetylcholine receptor M5

1

0

High-throughput

0.282

High

230300

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.279

Low

360603

SPTA1
Spectrin alpha chain, erythrocytic 1

1

0

Small-scale

0.249

Low

434590

SPDLY
Protein Spindly

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024