Protein: KCRU
Creatine kinase U-type, mitochondrial (EC 2.7.3.2) (Acidic-type mitochondrial creatine kinase) (Mia-CK) (Ubiquitous mitochondrial creatine kinase) (U-MtCK)

Gene: KCRU, CKMT1A
Organism: Homo sapiens
Interactions: 129
UniProt ID: P12532

Gene Ontology (top 5):
GO:0004111 - creatine kinase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0016310 - phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

519811

ASB9
Ankyrin repeat and SOCS box protein 9

7

5

Small-scale

0.967

High

519748

KCRS
Creatine kinase S-type, mitochondrial

3

4

High-throughput

0.855

High

417067

KCRM
Creatine kinase M-type

3

4

High-throughput

0.843

High

519114

KCRB
Creatine kinase B-type

3

4

High-throughput

0.827

High

519813

PP16A
Protein phosphatase 1 regulatory subunit 16A

2

0

High-throughput

0.655

High

519824

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.618

High

519772

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

2

1

High-throughput

0.611

High

128416

DNM1L
Dynamin-1-like protein

2

3

Small-scale

0.601

High

496187

TAU
Microtubule-associated protein tau

2

7

High-throughput

0.601

High

519749

PRS6A
26S proteasome regulatory subunit 6A

2

0

High-throughput

0.580

High

519759

RXRG
Retinoic acid receptor RXR-gamma

2

2

High-throughput

0.553

High

519767

NTF2
Nuclear transport factor 2

2

4

High-throughput

0.553

High

519766

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

0

High-throughput

0.546

High

519798

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

368890

ESR1
Estrogen receptor

2

3

High-throughput

0.521

High

519796

RHG36
Rho GTPase-activating protein 36

2

3

High-throughput

0.521

High

519746

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

147696

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

1

High-throughput

0.489

High

519781

LAMB3
Laminin subunit beta-3

1

2

High-throughput

0.489

High

519788

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

2

High-throughput

0.489

High

226385

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

231050

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

4

High-throughput

0.479

High

294314

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

325011

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

337848

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

384182

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

519762

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.479

High

519769

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

519799

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

519809

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

519814

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

519815

LMTK3
Serine/threonine-protein kinase LMTK3

1

4

High-throughput

0.479

High

519816

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

519825

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

1

High-throughput

0.479

High

519763

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

1

High-throughput

0.470

High

203865

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

274478

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

519745

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

519775

TRAF3
TNF receptor-associated factor 3

1

0

Small-scale

0.458

High

519782

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

519783

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

519789

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

519812

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

519817

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

519819

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

519821

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

519823

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

519826

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

519827

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

519829

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

174587

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.457

High

508798

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.445

High

519771

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.445

High

519778

G3BP1
Ras GTPase-activating protein-binding protein 1

1

4

High-throughput

0.445

High

519790

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

298106

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.437

High

302659

ARHGF
Rho guanine nucleotide exchange factor 15

1

1

High-throughput

0.437

High

378963

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

441854

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.437

High

453108

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.437

High

519747

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

519751

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.437

High

519752

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

519754

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

519756

MAP1B
Microtubule-associated protein 1B

1

3

High-throughput

0.437

High

519758

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.437

High

519770

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.437

High

519779

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

519780

CUL3
Cullin-3

1

3

High-throughput

0.437

High

519784

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

519785

EMC2
ER membrane protein complex subunit 2

1

3

High-throughput

0.437

High

519792

RC3H1
Roquin-1

1

3

High-throughput

0.437

High

519795

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.437

High

519797

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

519801

ARG39
Rho guanine nucleotide exchange factor 39

1

2

High-throughput

0.437

High

519810

ARHGQ
Rho guanine nucleotide exchange factor 26

1

1

High-throughput

0.437

High

519820

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.437

High

519833

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.437

High

519834

HECW2
E3 ubiquitin-protein ligase HECW2

1

2

High-throughput

0.437

High

519837

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.437

High

519839

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.437

High

330829

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

283373

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.407

High

401328

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

447838

SRP19
Signal recognition particle 19 kDa protein

1

1

High-throughput

0.407

High

451351

CLCA
Clathrin light chain A

1

1

High-throughput

0.407

High

519750

MX1
Interferon-induced GTP-binding protein Mx1

1

4

High-throughput

0.407

High

519755

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.407

High

519757

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.407

High

519760

CTCF
Transcriptional repressor CTCF

1

1

High-throughput

0.407

High

519761

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.407

High

519768

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.407

High

519806

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.407

High

519818

DNJC2
DnaJ homolog subfamily C member 2

1

1

High-throughput

0.407

High

519822

RBM42
RNA-binding protein 42

1

3

High-throughput

0.407

High

519835

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.407

High

519838

G3BP2
Ras GTPase-activating protein-binding protein 2

1

4

High-throughput

0.407

High

519840

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.407

High

474302

ONCO
Oncomodulin-1

2

0

High-throughput

0.320

High

519773

HPCA
Neuron-specific calcium-binding protein hippocalcin

2

0

High-throughput

0.316

High

519836

CTNA3
Catenin alpha-3

2

0

High-throughput

0.316

High

519794

SFRP4
Secreted frizzled-related protein 4

1

0

High-throughput

0.282

High

519776

FADD
FAS-associated death domain protein

1

0

High-throughput

0.279

Low

519800

LCORL
Ligand-dependent nuclear receptor corepressor-like protein

1

0

High-throughput

0.279

Low

519774

NPT2A
Sodium-dependent phosphate transport protein 2A

1

0

High-throughput

0.269

Low

519802

ARI2O
Uncharacterized protein ARIH2OS

1

0

High-throughput

0.269

Low

519808

KAT6B
Histone acetyltransferase KAT6B

1

0

High-throughput

0.269

Low

281521

WFS1
Wolframin

1

0

High-throughput

0.268

Low

519807

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

235684

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.249

Low

239485

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

342543

CAH2
Carbonic anhydrase 2

1

0

High-throughput

0.249

Low

354266

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

505540

EPB41
Protein 4.1

1

0

High-throughput

0.249

Low

519753

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.249

Low

519764

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.249

Low

519765

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.249

Low

519777

MMRN1
Multimerin-1

1

0

High-throughput

0.249

Low

519786

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

519787

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.249

Low

519803

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

519804

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

519805

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

519828

CSN7B
COP9 signalosome complex subunit 7b

1

0

High-throughput

0.249

Low

519830

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.249

Low

519831

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

519832

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

519791

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low

519793

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024