Protein: SP3
Transcription factor Sp3 (SPR-2)

Gene: SP3
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q02447

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

435052

SP1
Transcription factor Sp1

7

18

Small-scale

0.962

High

970913

HDAC1
Histone deacetylase 1

6

20

Small-scale

0.721

High

369440

ESR1
Estrogen receptor

4

20

Small-scale

0.683

High

970912

EP300
Histone acetyltransferase p300

4

20

Small-scale

0.676

High

585447

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

7

Small-scale

0.665

High

681798

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.647

High

970932

HDAC2
Histone deacetylase 2

3

20

Small-scale

0.640

High

386561

P53
Cellular tumor antigen p53

2

10

Small-scale

0.624

High

169707

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

20

Small-scale

0.618

High

632697

TYY1
Transcriptional repressor protein YY1

1

19

Small-scale

0.618

High

538914

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

1

High-throughput

0.606

High

970924

LIN54
Protein lin-54 homolog

2

3

High-throughput

0.606

High

970926

POGZ
Pogo transposable element with ZNF domain

2

17

High-throughput

0.606

High

970935

PF21A
PHD finger protein 21A

2

20

High-throughput

0.606

High

970936

SGCZ
Zeta-sarcoglycan

3

1

High-throughput

0.599

High

791495

HD
Huntingtin

2

6

High-throughput

0.596

High

885639

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

2

0

High-throughput

0.585

High

569615

CEBPB
CCAAT/enhancer-binding protein beta

2

12

Small-scale

0.584

High

970908

GABPA
GA-binding protein alpha chain

1

20

Small-scale

0.578

High

963591

E2F1
Transcription factor E2F1

1

9

Small-scale

0.561

High

970916

HLTF
Helicase-like transcription factor

1

13

Small-scale

0.561

High

970923

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

2

7

High-throughput

0.553

High

970937

CIB3
Calcium and integrin-binding family member 3

2

3

High-throughput

0.553

High

623242

AT5F1
ATP synthase F(0) complex subunit B1, mitochondrial

1

1

High-throughput

0.536

High

970915

FHL2
Four and a half LIM domains protein 2

1

20

High-throughput

0.536

High

278056

PIAS1
E3 SUMO-protein ligase PIAS1

1

4

Small-scale

0.527

High

970929

FNDC8
Fibronectin type III domain-containing protein 8

1

0

High-throughput

0.513

High

175857

P73
Tumor protein p73

1

10

Small-scale

0.501

High

549570

VEGFA
Vascular endothelial growth factor A, long form

1

1

Small-scale

0.501

High

970939

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

1

High-throughput

0.501

High

970918

PGFRL
Platelet-derived growth factor receptor-like protein

1

1

High-throughput

0.489

High

675825

GCH1
GTP cyclohydrolase 1

1

0

Small-scale

0.486

High

836139

STK19
Inactive serine/threonine-protein kinase 19

1

0

Small-scale

0.486

High

930151

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.481

High

970938

NKX31
Homeobox protein Nkx-3.1

1

20

Small-scale

0.481

High

197697

CRX
Cone-rod homeobox protein

1

11

Small-scale

0.479

High

263430

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

9

Small-scale

0.479

High

506109

ITAM
Integrin alpha-M

1

3

Small-scale

0.479

High

595510

ITAX
Integrin alpha-X

1

3

Small-scale

0.479

High

613425

SFPQ
Splicing factor, proline- and glutamine-rich

1

5

Small-scale

0.479

High

641198

DNMT1
DNA

1

11

Small-scale

0.479

High

737752

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

6

Small-scale

0.479

High

739953

TGFR2
TGF-beta receptor type-2

1

2

Small-scale

0.479

High

848014

MECP2
Methyl-CpG-binding protein 2

1

9

Small-scale

0.479

High

867183

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

Small-scale

0.479

High

966226

TFAP4
Transcription factor AP-4

1

2

Small-scale

0.479

High

970907

TF65
Transcription factor p65

1

10

Small-scale

0.479

High

970909

ZO1
Tight junction protein ZO-1

1

5

Small-scale

0.479

High

970911

RBBP4
Histone-binding protein RBBP4

1

11

Small-scale

0.479

High

970914

CUL3
Cullin-3

1

20

High-throughput

0.479

High

970919

PTPA
Serine/threonine-protein phosphatase 2A activator

1

1

Small-scale

0.479

High

970920

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

1

2

High-throughput

0.479

High

970931

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

970933

CBP
CREB-binding protein

1

20

Small-scale

0.479

High

970934

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

Small-scale

0.479

High

970943

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

892999

RS20
Small ribosomal subunit protein uS10

1

0

Small-scale

0.460

High

236362

B4GT4
Beta-1,4-galactosyltransferase 4

1

0

High-throughput

0.458

High

899719

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.458

High

437188

MDR1
ATP-dependent translocase ABCB1

1

1

Small-scale

0.457

High

970940

LN28A
Protein lin-28 homolog A

1

8

High-throughput

0.445

High

970942

GRHL1
Grainyhead-like protein 1 homolog

1

1

High-throughput

0.445

High

783466

S19A1
Reduced folate transporter

1

1

Small-scale

0.437

High

895609

CXCR4
C-X-C chemokine receptor type 4

1

2

Small-scale

0.437

High

970925

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.437

High

970941

IL21R
Interleukin-21 receptor

1

1

Small-scale

0.437

High

970910

Q08AT0
SGCZ protein

1

1

High-throughput

0.407

High

351667

TSHB
Thyrotropin subunit beta

2

0

High-throughput

0.328

High

970930

ITLN1
Intelectin-1

2

0

High-throughput

0.318

High

885683

NXPH1
Neurexophilin-1

1

0

High-throughput

0.279

Low

970917

MBTP1
Membrane-bound transcription factor site-1 protease

1

0

High-throughput

0.279

Low

970922

DB135
Beta-defensin 135

1

0

High-throughput

0.279

Low

970928

PRS33
Serine protease 33

1

0

High-throughput

0.279

Low

131308

CLD5
Claudin-5

1

0

Small-scale

0.249

Low

970921

OCLN
Occludin

1

0

Small-scale

0.249

Low

970927

TMM25
Transmembrane protein 25

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024