Protein: THG1
Probable tRNA(His) guanylyltransferase (EC 2.7.7.79) (Induced in high glucose-1) (IHG-1) (Interphase cytoplasmic foci protein 45) (tRNA-histidine guanylyltransferase)

Gene: THG1, THG1L
Organism: Homo sapiens
Interactions: 39
UniProt ID: Q9NWX6

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000287 - magnesium ion binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1451561

THG1
Probable tRNA(His) guanylyltransferase

3

2

Small-scale

0.870

High

1451563

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

3

0

High-throughput

0.638

High

1272919

3BP5L
SH3 domain-binding protein 5-like

2

0

High-throughput

0.602

High

1392936

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

279950

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

140461

SDCB1
Syntenin-1

1

0

High-throughput

0.549

High

508720

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

282108

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

1083779

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

1090570

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

287396

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.458

High

533011

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

828987

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

852058

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

1117866

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1142687

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1162593

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1234549

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1381750

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.458

High

1388295

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1412459

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1415691

TR61B
tRNA

1

0

High-throughput

0.458

High

1416566

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1418909

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1431980

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1436114

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1451562

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1451564

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

1451565

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

1234981

PKHA7
Pleckstrin homology domain-containing family A member 7

1

0

High-throughput

0.426

High

1385572

ZN524
Zinc finger protein 524

3

0

High-throughput

0.347

High

1348543

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.316

High

1436611

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.316

High

928568

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.299

High

1324697

ELMD1
ELMO domain-containing protein 1

1

0

High-throughput

0.282

High

589855

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696675

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

1255802

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025