Protein: DUS22
Dual specificity protein phosphatase 22 (EC 3.1.3.16) (EC 3.1.3.48) (JNK-stimulatory phosphatase-1) (JSP-1) (Low molecular weight dual specificity phosphatase 2) (LMW-DSP2) (Mitogen-activated protein kinase phosphatase x) (MAP kinase phosphatase x) (MKP-x)

Gene: DUS22, DUSP22
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q9NRW4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0002710 - negative regulation of T cell mediated immunity
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

60426

POTEF
POTE ankyrin domain family member F

2

14

High-throughput

0.811

High

617145

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

2

1

High-throughput

0.811

High

1345167

KC1G3
Casein kinase I isoform gamma-3

1

2

High-throughput

0.691

High

349673

RASH
GTPase HRas

3

8

High-throughput

0.667

High

325971

GNA14
Guanine nucleotide-binding protein subunit alpha-14

2

14

High-throughput

0.628

High

837651

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

2

15

High-throughput

0.628

High

862201

ARFP2
Arfaptin-2

2

1

High-throughput

0.628

High

1079448

VAMP3
Vesicle-associated membrane protein 3

2

1

High-throughput

0.628

High

1237221

CCYL1
Cyclin-Y-like protein 1

2

1

High-throughput

0.628

High

415081

CDK1
Cyclin-dependent kinase 1

1

4

High-throughput

0.618

High

1116777

DUS28
Dual specificity phosphatase 28

1

16

High-throughput

0.618

High

1313933

DUS23
Dual specificity protein phosphatase 23

1

16

High-throughput

0.618

High

1327249

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.618

High

1345150

DUS22
Dual specificity protein phosphatase 22

1

17

High-throughput

0.618

High

919677

RAP1A
Ras-related protein Rap-1A

2

8

High-throughput

0.611

High

1056284

I5P1
Inositol polyphosphate-5-phosphatase A

2

0

High-throughput

0.602

High

1152128

LTOR1
Ragulator complex protein LAMTOR1

2

0

High-throughput

0.602

High

1342638

NRN1
Neuritin

2

0

High-throughput

0.602

High

1344087

DBLOH
Diablo IAP-binding mitochondrial protein

2

0

High-throughput

0.602

High

1245505

SVIP
Small VCP/p97-interacting protein

2

0

High-throughput

0.585

High

1064970

SYLM
Leucine--tRNA ligase, mitochondrial

2

2

High-throughput

0.574

High

136074

ACACB
Acetyl-CoA carboxylase 2

1

3

High-throughput

0.536

High

237328

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.536

High

433487

YES
Tyrosine-protein kinase Yes

1

11

High-throughput

0.536

High

451043

GNAO

1

14

High-throughput

0.536

High

640740

CTNA2
Catenin alpha-2

1

3

High-throughput

0.536

High

665958

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

5

High-throughput

0.536

High

670490

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

15

High-throughput

0.536

High

841482

BPL1
Biotin--protein ligase

1

1

High-throughput

0.536

High

894981

SRP54
Signal recognition particle subunit SRP54

1

2

High-throughput

0.536

High

929177

GBG5

1

1

High-throughput

0.536

High

1022617

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

2

High-throughput

0.536

High

1053443

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

14

High-throughput

0.536

High

1148981

CYTSA
Cytospin-A

1

4

High-throughput

0.536

High

1242194

CCNY
Cyclin-Y

1

1

High-throughput

0.536

High

1318272

ULBP3
UL16-binding protein 3

1

1

High-throughput

0.536

High

1318280

ULBP2
UL16-binding protein 2

1

1

High-throughput

0.536

High

1345163

FBX7
F-box only protein 7

1

1

High-throughput

0.536

High

274858

PALM
Paralemmin-1

1

0

High-throughput

0.513

High

562960

STMN1
Stathmin

1

0

High-throughput

0.513

High

1183813

5MP2
eIF5-mimic protein 2

1

0

High-throughput

0.513

High

1260452

UBTD2
Ubiquitin domain-containing protein 2

1

0

High-throughput

0.513

High

1345152

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.513

High

1021829

TP4A2
Protein tyrosine phosphatase type IVA 2

1

5

Small-scale

0.501

High

830034

HXA1
Homeobox protein Hox-A1

1

2

High-throughput

0.494

High

362107

MBP
Myelin basic protein

1

0

High-throughput

0.493

High

648618

CALL3
Calmodulin-like protein 3

1

2

High-throughput

0.489

High

1345151

CUED1
CUE domain-containing protein 1

1

1

High-throughput

0.489

High

123737

PGRC1
Membrane-associated progesterone receptor component 1

1

4

High-throughput

0.479

High

330736

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

1

High-throughput

0.479

High

350588

RASK
GTPase KRas

1

11

High-throughput

0.479

High

391472

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

15

High-throughput

0.479

High

430496

APT
Adenine phosphoribosyltransferase

1

3

High-throughput

0.479

High

438991

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

1

High-throughput

0.479

High

444799

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

15

High-throughput

0.479

High

548958

NDKA
Nucleoside diphosphate kinase A

1

6

High-throughput

0.479

High

565410

TMM11
Transmembrane protein 11, mitochondrial

1

3

High-throughput

0.479

High

574759

ARF4
ADP-ribosylation factor 4

1

9

High-throughput

0.479

High

592521

RAB5A
Ras-related protein Rab-5A

1

8

High-throughput

0.479

High

674269

HMOX2
Heme oxygenase 2

1

1

High-throughput

0.479

High

728664

PPM1A
Protein phosphatase 1A

1

1

High-throughput

0.479

High

741915

TAGL2
Transgelin-2

1

5

High-throughput

0.479

High

776193

ARL1
ADP-ribosylation factor-like protein 1

1

10

High-throughput

0.479

High

800634

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

6

High-throughput

0.479

High

803985

NSF
Vesicle-fusing ATPase

1

4

High-throughput

0.479

High

844759

RAB5C
Ras-related protein Rab-5C

1

8

High-throughput

0.479

High

845761

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

849148

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.479

High

856195

SPSY
Spermine synthase

1

6

High-throughput

0.479

High

884657

CORO7
Coronin-7

1

5

High-throughput

0.479

High

895559

RAB10
Ras-related protein Rab-10

1

3

High-throughput

0.479

High

896689

RAB14
Ras-related protein Rab-14

1

2

High-throughput

0.479

High

926719

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

15

High-throughput

0.479

High

950565

ARF1
ADP-ribosylation factor 1

1

9

High-throughput

0.479

High

950723

ARF5
ADP-ribosylation factor 5

1

9

High-throughput

0.479

High

993077

RHG01
Rho GTPase-activating protein 1

1

1

High-throughput

0.479

High

1028354

NDK3
Nucleoside diphosphate kinase 3

1

6

High-throughput

0.479

High

1061961

GAPD1
GTPase-activating protein and VPS9 domain-containing protein 1

1

2

High-throughput

0.479

High

1160507

MEAK7
MTOR-associated protein MEAK7

1

1

High-throughput

0.479

High

1268263

GCN1
Stalled ribosome sensor GCN1

1

8

High-throughput

0.479

High

1295327

TMX3
Protein disulfide-isomerase TMX3

1

4

High-throughput

0.479

High

1299685

QKI
KH domain-containing RNA-binding protein QKI

1

3

High-throughput

0.479

High

1305453

CHP1
Calcineurin B homologous protein 1

1

2

High-throughput

0.479

High

1330380

UN45A
Protein unc-45 homolog A

1

4

High-throughput

0.479

High

1345162

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

3

High-throughput

0.479

High

118082

SNP23
Synaptosomal-associated protein 23

1

0

High-throughput

0.458

High

152178

STX16
Syntaxin-16

1

0

High-throughput

0.458

High

213170

SNG1
Synaptogyrin-1

1

0

High-throughput

0.458

High

231166

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.458

High

805821

RL27A
Large ribosomal subunit protein uL15

1

0

High-throughput

0.458

High

897833

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

992202

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

0

High-throughput

0.458

High

1261732

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.458

High

1303175

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.458

High

1306091

NP1L4
Nucleosome assembly protein 1-like 4

1

0

High-throughput

0.458

High

1345155

ATX10
Ataxin-10

1

0

High-throughput

0.458

High

1345156

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.458

High

1345158

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

High-throughput

0.458

High

1345159

MSPD1
Motile sperm domain-containing protein 1

1

0

High-throughput

0.458

High

1345161

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.458

High

1345165

COPG1
Coatomer subunit gamma-1

1

0

High-throughput

0.458

High

118471

HAX1
HCLS1-associated protein X-1

1

4

High-throughput

0.437

High

156565

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.437

High

170963

PGRC2
Membrane-associated progesterone receptor component 2

1

4

High-throughput

0.437

High

196873

CYB5B
Cytochrome b5 type B

1

2

High-throughput

0.437

High

242199

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

1

5

High-throughput

0.437

High

242293

PRAF2
PRA1 family protein 2

1

3

High-throughput

0.437

High

438870

SRPRA
Signal recognition particle receptor subunit alpha

1

2

High-throughput

0.437

High

708526

MCM4
DNA replication licensing factor MCM4

1

7

High-throughput

0.437

High

1055639

MCM6
DNA replication licensing factor MCM6

1

7

High-throughput

0.437

High

1058562

GANAB
Neutral alpha-glucosidase AB

1

4

High-throughput

0.437

High

1261272

DCAKD
Dephospho-CoA kinase domain-containing protein

1

1

High-throughput

0.437

High

1303115

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

5

High-throughput

0.437

High

1304855

TI17A
Mitochondrial import inner membrane translocase subunit Tim17-A

1

5

High-throughput

0.437

High

1312721

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.437

High

1313445

WDR18
WD repeat-containing protein 18

1

1

High-throughput

0.437

High

1314258

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

1

High-throughput

0.437

High

1326900

MFF
Mitochondrial fission factor

1

1

High-throughput

0.437

High

1330217

TMX1
Thioredoxin-related transmembrane protein 1

1

6

High-throughput

0.437

High

1345154

MTCH1
Mitochondrial carrier homolog 1

1

6

High-throughput

0.437

High

1345160

TMCO1
Calcium load-activated calcium channel

1

1

High-throughput

0.437

High

1345166

MTCH2
Mitochondrial carrier homolog 2

1

6

High-throughput

0.437

High

740698

HPCL1
Hippocalcin-like protein 1

2

0

High-throughput

0.328

High

1116798

KCD21
BTB/POZ domain-containing protein KCTD21

2

0

High-throughput

0.328

High

1250950

OCC1
Overexpressed in colon carcinoma 1 protein

2

0

High-throughput

0.328

High

1012681

LTOR4
Ragulator complex protein LAMTOR4

1

0

High-throughput

0.279

Low

1160336

ERIC5
Glutamate-rich protein 5

1

0

High-throughput

0.279

Low

1174429

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

High-throughput

0.279

Low

263372

SC22B
Vesicle-trafficking protein SEC22b

1

0

High-throughput

0.249

Low

1160453

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.249

Low

1230115

F177A
Protein FAM177A1

1

0

High-throughput

0.249

Low

1282656

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.249

Low

1309573

APOL2
Apolipoprotein L2

1

0

High-throughput

0.249

Low

1345153

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.249

Low

1345157

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.249

Low

1345164

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024