Protein: MP2K1
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)

Gene: MP2K1, Map2k1
Organism: Mus musculus
Interactions: 31
UniProt ID: P31938

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0003056 - regulation of vascular associated smooth muscle contraction
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

728910

KSR1
Kinase suppressor of Ras 1

7

20

Small-scale

0.959

High

728920

RAF1
RAF proto-oncogene serine/threonine-protein kinase

5

20

Small-scale

0.910

High

728903

MK01
Mitogen-activated protein kinase 1

2

20

Small-scale

0.778

High

700327

BRAF
Serine/threonine-protein kinase B-raf

2

20

Small-scale

0.775

High

205251

AXIN1
Axin-1

2

1

Small-scale

0.754

High

728908

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

4

High-throughput

0.691

High

728914

DJC27
DnaJ homolog subfamily C member 27

1

7

Small-scale

0.647

High

107135

F8VQ72
Mitogen-activated protein kinase kinase kinase 1

1

18

Small-scale

0.618

High

728901

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

6

High-throughput

0.618

High

728907

NEK10
Serine/threonine-protein kinase Nek10

1

19

Small-scale

0.618

High

728915

TRIB1
Tribbles homolog 1

1

19

Small-scale

0.618

High

591007

KPCE
Protein kinase C epsilon type

1

19

Small-scale

0.575

High

205504

CFLAR
CASP8 and FADD-like apoptosis regulator

1

11

Small-scale

0.553

High

518501

MYOD1
Myoblast determination protein 1

1

0

Small-scale

0.537

High

104468

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

13

High-throughput

0.536

High

728900

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

6

High-throughput

0.536

High

728921

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

20

Small-scale

0.500

High

108483

G3X9H5
Huntingtin

1

1

High-throughput

0.479

High

530713

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.479

High

728902

ATX1
Ataxin-1

1

4

High-throughput

0.479

High

728904

PEBP1
Phosphatidylethanolamine-binding protein 1

1

7

Small-scale

0.479

High

728905

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

6

High-throughput

0.479

High

728906

STING
Stimulator of interferon genes protein

1

3

High-throughput

0.479

High

728911

MABP1
Mitogen-activated protein kinase-binding protein 1

1

15

Small-scale

0.479

High

728912

NEB2
Neurabin-2

1

7

High-throughput

0.479

High

728913

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

5

High-throughput

0.479

High

728916

PAXI
Paxillin

1

8

Small-scale

0.479

High

728917

EED
Polycomb protein EED

1

15

High-throughput

0.479

High

728918

FOXP3
Forkhead box protein P3

1

6

High-throughput

0.479

High

728919

BRAP
BRCA1-associated protein

1

15

Small-scale

0.479

High

728909

SC6A4
Sodium-dependent serotonin transporter

1

0

High-throughput

0.458

High


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Last updated: 11Aug2025