Protein: LEF1
Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)

Gene: LEF1
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q9UJU2

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001222 - transcription corepressor binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

717411

CTNB1
Catenin beta-1

26

20

Small-scale

0.991

High

1353978

NLK
Serine/threonine-protein kinase NLK

5

8

Small-scale

0.710

High

252934

MITF
Microphthalmia-associated transcription factor

3

10

Small-scale

0.682

High

1297036

ANM6
Protein arginine N-methyltransferase 6

3

2

High-throughput

0.662

High

950317

SMAD3
Mothers against decapentaplegic homolog 3

2

20

Small-scale

0.646

High

980665

TLE1
Transducin-like enhancer protein 1

2

20

Small-scale

0.635

High

1078692

SMAD2
Mothers against decapentaplegic homolog 2

2

20

Small-scale

0.624

High

1261310

RN138
E3 ubiquitin-protein ligase RNF138

2

14

Small-scale

0.624

High

542475

PLAK
Junction plakoglobin

1

20

Small-scale

0.618

High

567787

UBF1
Nucleolar transcription factor 1

1

20

Small-scale

0.618

High

590575

PO3F2
POU domain, class 3, transcription factor 2

1

20

Small-scale

0.618

High

626281

APC
Adenomatous polyposis coli protein

1

17

Small-scale

0.618

High

1343262

TF7L2
Transcription factor 7-like 2

1

19

Small-scale

0.618

High

167406

SMAD7
Mothers against decapentaplegic homolog 7

2

20

Small-scale

0.601

High

1081258

NF2L2
Nuclear factor erythroid 2-related factor 2

1

8

Small-scale

0.582

High

999186

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.578

High

1231873

PIAS4
E3 SUMO-protein ligase PIAS4

1

10

Small-scale

0.573

High

575618

EGR1
Early growth response protein 1

2

13

Small-scale

0.571

High

814676

CDX1
Homeobox protein CDX-1

1

20

Small-scale

0.561

High

1343546

KMT5A
N-lysine methyltransferase KMT5A

1

14

Small-scale

0.561

High

1355548

NARF
Nuclear prelamin A recognition factor

2

0

Small-scale

0.559

High

834559

FHIT
Bis(5'-adenosyl)-triphosphatase

1

1

Small-scale

0.554

High

160837

AURKA
Aurora kinase A

1

14

High-throughput

0.541

High

211071

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

9

High-throughput

0.541

High

414394

RB
Retinoblastoma-associated protein

1

3

High-throughput

0.541

High

776424

MLH1
DNA mismatch repair protein Mlh1

1

1

High-throughput

0.541

High

794337

MSH2
DNA mismatch repair protein Msh2

1

2

High-throughput

0.541

High

1079181

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.541

High

1331994

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

20

High-throughput

0.541

High

1355317

MLH3
DNA mismatch repair protein Mlh3

1

1

High-throughput

0.541

High

435798

IGF1R
Insulin-like growth factor 1 receptor

1

3

Small-scale

0.536

High

1305655

PITX2
Pituitary homeobox 2

1

20

Small-scale

0.527

High

992051

BAX
Apoptosis regulator BAX

1

0

High-throughput

0.518

High

804363

NOTC1
Neurogenic locus notch homolog protein 1

1

4

Small-scale

0.501

High

980723

TLE2
Transducin-like enhancer protein 2

1

20

Small-scale

0.501

High

1035624

SMAD4
Mothers against decapentaplegic homolog 4

1

20

Small-scale

0.501

High

1201199

THOC4
THO complex subunit 4

1

9

Small-scale

0.501

High

509993

VDR
Vitamin D3 receptor

1

17

Small-scale

0.500

High

348994

RASN
GTPase NRas

1

5

High-throughput

0.494

High

1083156

DPYL2
Dihydropyrimidinase-related protein 2

1

2

High-throughput

0.494

High

196366

PJA2
E3 ubiquitin-protein ligase Praja-2

1

2

Small-scale

0.479

High

318030

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

11

High-throughput

0.479

High

486843

MYB
Transcriptional activator Myb

1

5

Small-scale

0.479

High

591140

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

786642

STA5A
Signal transducer and activator of transcription 5A

1

1

Small-scale

0.479

High

834513

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

1

Small-scale

0.479

High

963696

E2F1
Transcription factor E2F1

1

4

Small-scale

0.479

High

1035290

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

9

High-throughput

0.479

High

1038795

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.479

High

1065211

DAZP2
DAZ-associated protein 2

1

5

Small-scale

0.479

High

1078773

SMAD1
Mothers against decapentaplegic homolog 1

1

20

Small-scale

0.479

High

1348447

DACT1
Dapper homolog 1

1

7

Small-scale

0.479

High

1354301

RNF14
E3 ubiquitin-protein ligase RNF14

1

1

Small-scale

0.479

High

1356031

CHIP
E3 ubiquitin-protein ligase CHIP

1

9

Small-scale

0.479

High

1356032

RUVB1
RuvB-like 1

1

8

Small-scale

0.479

High

1332741

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1022671

AF1Q
Protein AF1q

1

1

Small-scale

0.457

High

551310

ITF2
Transcription factor 4

1

6

Small-scale

0.445

High

872589

EPHB4
Ephrin type-B receptor 4

1

2

Small-scale

0.437

High

976308

KIME
Mevalonate kinase

1

0

High-throughput

0.279

Low

768516

TYRP2
L-dopachrome tautomerase

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024