Protein: AKA12
A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)

Gene: AKA12, AKAP12
Organism: Homo sapiens
Interactions: 161
UniProt ID: Q02952

Gene Ontology (top 5):
GO:0005516 - calmodulin binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568792

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

3

5

Small-scale

0.847

High

531047

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

6

High-throughput

0.737

High

1039943

FHL1
Four and a half LIM domains protein 1

3

12

High-throughput

0.674

High

212948

HS12A
Heat shock 70 kDa protein 12A

3

1

High-throughput

0.671

High

603241

KPCA
Protein kinase C alpha type

3

4

Small-scale

0.633

High

363158

EGFR
Epidermal growth factor receptor

2

14

Small-scale

0.624

High

764677

CTNB1
Catenin beta-1

2

8

High-throughput

0.611

High

1039981

HS12B
Heat shock 70 kDa protein 12B

3

1

High-throughput

0.593

High

1039965

EID3
EP300-interacting inhibitor of differentiation 3

2

0

High-throughput

0.585

High

540410

LAMP1
Lysosome-associated membrane glycoprotein 1

2

2

High-throughput

0.584

High

582753

EZRI
Ezrin

2

9

High-throughput

0.584

High

976215

RB11A
Ras-related protein Rab-11A

2

2

High-throughput

0.584

High

410782

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

14

High-throughput

0.576

High

176965

CE290
Centrosomal protein of 290 kDa

2

17

High-throughput

0.571

High

193551

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

2

High-throughput

0.571

High

249750

DOK2
Docking protein 2

2

1

High-throughput

0.571

High

436659

KPCB
Protein kinase C beta type

2

4

High-throughput

0.571

High

473399

HCK
Tyrosine-protein kinase HCK

2

10

High-throughput

0.571

High

557241

SRC
Proto-oncogene tyrosine-protein kinase Src

2

10

High-throughput

0.571

High

635709

RASA1
Ras GTPase-activating protein 1

2

12

High-throughput

0.571

High

702344

ELK4
ETS domain-containing protein Elk-4

2

11

High-throughput

0.571

High

711313

SHC1
SHC-transforming protein 1

2

13

High-throughput

0.571

High

858633

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

15

High-throughput

0.571

High

905740

CAV2
Caveolin-2

2

3

High-throughput

0.571

High

936939

CASP9
Caspase-9

2

1

High-throughput

0.571

High

987556

GRB2
Growth factor receptor-bound protein 2

2

16

High-throughput

0.571

High

1034981

KPCE
Protein kinase C epsilon type

2

3

High-throughput

0.571

High

1038277

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

15

High-throughput

0.571

High

1039940

PAK1
Serine/threonine-protein kinase PAK 1

2

6

High-throughput

0.571

High

1039946

KPCD1
Serine/threonine-protein kinase D1

2

7

High-throughput

0.571

High

1039964

ABI1
Abl interactor 1

2

4

High-throughput

0.571

High

1039968

SH2D3
SH2 domain-containing protein 3C

2

18

High-throughput

0.571

High

1039977

SH3K1
SH3 domain-containing kinase-binding protein 1

2

12

High-throughput

0.571

High

1039982

SCLT1
Sodium channel and clathrin linker 1

2

14

High-throughput

0.571

High

1039984

SH3G3
Endophilin-A3

2

10

High-throughput

0.571

High

458381

ADRB2
Beta-2 adrenergic receptor

1

4

Small-scale

0.561

High

919898

PLK1
Serine/threonine-protein kinase PLK1

1

7

Small-scale

0.561

High

289980

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.547

High

231469

ORC4
Origin recognition complex subunit 4

1

1

High-throughput

0.536

High

274312

SIN3B
Paired amphipathic helix protein Sin3b

1

2

High-throughput

0.536

High

358670

LDHA
L-lactate dehydrogenase A chain

1

3

High-throughput

0.536

High

408822

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.536

High

563649

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

605643

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

High-throughput

0.536

High

956260

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.536

High

1039942

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

16

High-throughput

0.536

High

1040003

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

2

High-throughput

0.536

High

105786

APRIO
Alternative prion protein

2

6

High-throughput

0.533

High

541092

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1040002

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.513

High

443319

CDK1
Cyclin-dependent kinase 1

1

5

Small-scale

0.501

High

951626

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.501

High

1039936

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

0

Small-scale

0.493

High

1039938

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.489

High

1039979

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

10

High-throughput

0.489

High

126558

RHOD
Rho-related GTP-binding protein RhoD

1

18

High-throughput

0.479

High

164152

KIF3C
Kinesin-like protein KIF3C

1

3

High-throughput

0.479

High

176606

KIF3B
Kinesin-like protein KIF3B

1

3

High-throughput

0.479

High

189522

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

218079

TGON2
Trans-Golgi network integral membrane protein 2

1

14

High-throughput

0.479

High

293588

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

299159

FLOT1
Flotillin-1

1

2

High-throughput

0.479

High

345694

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

20

High-throughput

0.479

High

348470

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

373892

RASN
GTPase NRas

1

10

High-throughput

0.479

High

375430

RASK
GTPase KRas

1

10

High-throughput

0.479

High

413665

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

446927

NPM
Nucleophosmin

1

4

High-throughput

0.479

High

463466

LYN
Tyrosine-protein kinase Lyn

1

10

High-throughput

0.479

High

532532

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

537008

HSP7C
Heat shock cognate 71 kDa protein

1

10

High-throughput

0.479

High

562007

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

565874

EF2
Elongation factor 2

1

5

High-throughput

0.479

High

567377

TCTP
Translationally-controlled tumor protein

1

2

High-throughput

0.479

High

581000

RAC2
Ras-related C3 botulinum toxin substrate 2

1

12

High-throughput

0.479

High

601247

RHOQ
Rho-related GTP-binding protein RhoQ

1

17

High-throughput

0.479

High

631178

RAB5A
Ras-related protein Rab-5A

1

3

High-throughput

0.479

High

642812

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.479

High

710186

EPHA2
Ephrin type-A receptor 2

1

7

High-throughput

0.479

High

720196

UFO
Tyrosine-protein kinase receptor UFO

1

8

Small-scale

0.479

High

799014

BRCA1
Breast cancer type 1 susceptibility protein

1

13

High-throughput

0.479

High

845608

MUC18
Cell surface glycoprotein MUC18

1

3

High-throughput

0.479

High

894533

GDIB
Rab GDP dissociation inhibitor beta

1

3

High-throughput

0.479

High

901196

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.479

High

941775

ARL4C
ADP-ribosylation factor-like protein 4C

1

9

High-throughput

0.479

High

953402

RAC3
Ras-related C3 botulinum toxin substrate 3

1

13

High-throughput

0.479

High

955077

CDC42
Cell division control protein 42 homolog

1

14

High-throughput

0.479

High

961972

RHOA
Transforming protein RhoA

1

16

High-throughput

0.479

High

962716

RND3
Rho-related GTP-binding protein RhoE

1

14

High-throughput

0.479

High

974995

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

977950

RHOB
Rho-related GTP-binding protein RhoB

1

16

High-throughput

0.479

High

988298

RAC1
Ras-related C3 botulinum toxin substrate 1

1

14

High-throughput

0.479

High

1015379

RHOG
Rho-related GTP-binding protein RhoG

1

13

High-throughput

0.479

High

1039935

CAV1
Caveolin-1

1

3

High-throughput

0.479

High

1039937

FOXO1
Forkhead box protein O1

1

7

High-throughput

0.479

High

1039939

STK4
Serine/threonine-protein kinase 4

1

10

High-throughput

0.479

High

1039944

TRI14
Tripartite motif-containing protein 14

1

2

High-throughput

0.479

High

1039945

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

8

High-throughput

0.479

High

1039947

RAB35
Ras-related protein Rab-35

1

3

High-throughput

0.479

High

1039948

RHOH
Rho-related GTP-binding protein RhoH

1

16

High-throughput

0.479

High

1039951

AR13B
ADP-ribosylation factor-like protein 13B

1

2

High-throughput

0.479

High

1039953

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

1039956

RHDF2
Inactive rhomboid protein 2

1

2

High-throughput

0.479

High

1039959

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

1039960

RHOU
Rho-related GTP-binding protein RhoU

1

17

High-throughput

0.479

High

1039961

ZN598
E3 ubiquitin-protein ligase ZNF598

1

10

High-throughput

0.479

High

1039962

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1039966

ARL14
ADP-ribosylation factor-like protein 14

1

2

High-throughput

0.479

High

1039969

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.479

High

1039971

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1039972

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

20

High-throughput

0.479

High

1039973

NECT2
Nectin-2

1

3

High-throughput

0.479

High

1039975

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1039983

FMNL2
Formin-like protein 2

1

1

High-throughput

0.479

High

1039985

CP250
Centrosome-associated protein CEP250

1

12

High-throughput

0.479

High

1039987

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

1039988

SAV1
Protein salvador homolog 1

1

9

High-throughput

0.479

High

1039990

RHOJ
Rho-related GTP-binding protein RhoJ

1

16

High-throughput

0.479

High

1039991

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.479

High

1039993

RHOF
Rho-related GTP-binding protein RhoF

1

17

High-throughput

0.479

High

1039999

HDAC6
Protein deacetylase HDAC6

1

10

Small-scale

0.479

High

1040000

PRP19
Pre-mRNA-processing factor 19

1

17

Small-scale

0.479

High

1040001

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

154476

CLD4
Claudin-4

1

0

Small-scale

0.458

High

226000

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

580617

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

1039950

OCLN
Occludin

1

0

High-throughput

0.458

High

1039978

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.458

High

190345

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.445

High

295491

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

11

High-throughput

0.445

High

844756

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.445

High

934490

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.445

High

943919

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

7

High-throughput

0.445

High

1010907

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.445

High

1039941

U119A
Protein unc-119 homolog A

1

1

High-throughput

0.445

High

1039952

S39AC
Zinc transporter ZIP12

1

3

High-throughput

0.445

High

1039957

ZNT10
Calcium/manganese antiporter SLC30A10

1

2

High-throughput

0.445

High

1039958

S39A5
Zinc transporter ZIP5

1

3

High-throughput

0.445

High

1039963

DND1
Dead end protein homolog 1

1

5

High-throughput

0.445

High

1039994

S39A9
Zinc transporter ZIP9

1

3

High-throughput

0.445

High

1039998

S53A1
Solute carrier family 53 member 1

1

1

High-throughput

0.445

High

1040004

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

2

High-throughput

0.445

High

296232

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.437

High

1039989

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.437

High

1039995

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

4

High-throughput

0.437

High

1039996

ARL15
ADP-ribosylation factor-like protein 15

1

4

High-throughput

0.437

High

880798

NRAM1
Natural resistance-associated macrophage protein 1

1

0

High-throughput

0.426

High

1039955

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

1039970

S22A8
Organic anion transporter 3

1

0

High-throughput

0.426

High

1039974

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.426

High

1039997

RHCG
Ammonium transporter Rh type C

1

0

High-throughput

0.426

High

1039954

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

7

High-throughput

0.407

High

1039980

S39AD
Zinc transporter ZIP13

1

3

High-throughput

0.407

High

1039949

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.279

Low

327231

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

1039976

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1039986

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

Small-scale

0.249

Low

1039992

SFXN1
Sideroflexin-1

1

0

High-throughput

0.249

Low

238773

SSX4
Protein SSX4

1

0

High-throughput

0.232

Low

653266

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1039967

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025