Protein: CREL1
Protein disulfide isomerase CRELD1 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 1)

Gene: CREL1, CRELD1
Organism: Homo sapiens
Interactions: 176
UniProt ID: Q96HD1

Gene Ontology (top 5):
GO:0003197 - endocardial cushion development
GO:0003279 - cardiac septum development
GO:0003756 - protein disulfide isomerase activity
GO:0005509 - calcium ion binding
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1393079

P2Y12
P2Y purinoceptor 12

3

5

High-throughput

0.667

High

1393094

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

0

High-throughput

0.656

High

1316347

AGRG5
Adhesion G-protein coupled receptor G5

2

3

High-throughput

0.601

High

1324752

S35F6
Solute carrier family 35 member F6

2

2

High-throughput

0.601

High

1366172

LPAR1
Lysophosphatidic acid receptor 1

2

5

High-throughput

0.571

High

689847

CD27
CD27 antigen

2

1

High-throughput

0.558

High

1393097

FZD10
Frizzled-10

2

5

High-throughput

0.549

High

572460

DRD2
D(2) dopamine receptor

1

4

High-throughput

0.541

High

1277889

NUFP2
FMR1-interacting protein NUFIP2

1

6

High-throughput

0.541

High

180015

BET1
BET1 homolog

1

1

High-throughput

0.536

High

190578

MRP3
ATP-binding cassette sub-family C member 3

1

5

High-throughput

0.536

High

190629

MRP4
ATP-binding cassette sub-family C member 4

1

5

High-throughput

0.536

High

228103

PM34
Peroxisomal membrane protein PMP34

1

2

High-throughput

0.536

High

420033

B3A2
Anion exchange protein 2

1

5

High-throughput

0.536

High

701892

ABCD3
ATP-binding cassette sub-family D member 3

1

5

High-throughput

0.536

High

755369

ABCD1
ATP-binding cassette sub-family D member 1

1

5

High-throughput

0.536

High

847432

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

896286

PEX5
Peroxisomal targeting signal 1 receptor

1

4

High-throughput

0.536

High

1212721

TMTC4
Protein O-mannosyl-transferase TMTC4

1

6

High-throughput

0.536

High

1240581

MBOA5
Lysophospholipid acyltransferase 5

1

1

High-throughput

0.536

High

1251737

CERS6
Ceramide synthase 6

1

1

High-throughput

0.536

High

1257538

TMTC3
Protein O-mannosyl-transferase TMTC3

1

6

High-throughput

0.536

High

1275393

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

2

High-throughput

0.536

High

1310836

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

2

High-throughput

0.536

High

1315472

K2013
Uncharacterized protein KIAA2013

1

1

High-throughput

0.536

High

1335149

LEMD2
LEM domain-containing protein 2

1

1

High-throughput

0.536

High

1346755

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

7

High-throughput

0.536

High

1349999

SPPL3
Signal peptide peptidase-like 3

1

1

High-throughput

0.536

High

1350036

SPP2B
Signal peptide peptidase-like 2B

1

1

High-throughput

0.536

High

1384620

S67A1
Solute carrier family 67 member A1

1

7

High-throughput

0.536

High

1393063

F210B
Protein FAM210B, mitochondrial

1

1

High-throughput

0.536

High

1393064

TLCD4
TLC domain-containing protein 4

1

1

High-throughput

0.536

High

1393065

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

1

High-throughput

0.536

High

1393068

NDC1
Nucleoporin NDC1

1

1

High-throughput

0.536

High

1393073

TACAN
Transmembrane protein 120A

1

2

High-throughput

0.536

High

1393076

DERL2
Derlin-2

1

1

High-throughput

0.536

High

1393082

TM9S3
Transmembrane 9 superfamily member 3

1

1

High-throughput

0.536

High

1393083

AT132
Polyamine-transporting ATPase 13A2

1

3

High-throughput

0.536

High

1393086

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.536

High

1393091

ELOV5
Very long chain fatty acid elongase 5

1

3

High-throughput

0.536

High

1393101

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.536

High

1393103

ALG6
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

2

High-throughput

0.536

High

688106

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.518

High

1360721

JPH3
Junctophilin-3

1

2

High-throughput

0.515

High

212597

GPAA1
GPI-anchor transamidase component GPAA1

1

0

High-throughput

0.513

High

354470

PX11B
Peroxisomal membrane protein 11B

1

0

High-throughput

0.513

High

773957

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

878695

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

1

0

High-throughput

0.513

High

1179672

D19L1
Protein C-mannosyl-transferase DPY19L1

1

0

High-throughput

0.513

High

1205471

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.513

High

1228844

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

0

High-throughput

0.513

High

1327931

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.513

High

1337035

TM104
Transmembrane protein 104

1

0

High-throughput

0.513

High

1348039

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.513

High

1370205

CDS1
Phosphatidate cytidylyltransferase 1

1

0

High-throughput

0.513

High

1393066

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.513

High

1393069

LMF2
Lipase maturation factor 2

1

0

High-throughput

0.513

High

1393070

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

1

0

High-throughput

0.513

High

1393077

TM39B
Transmembrane protein 39B

1

0

High-throughput

0.513

High

1393080

PIGU
GPI-anchor transamidase component PIGU

1

0

High-throughput

0.513

High

1393085

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.513

High

1393087

AAAS
Aladin

1

0

High-throughput

0.513

High

1393088

S38A7
Sodium-coupled neutral amino acid transporter 7

1

0

High-throughput

0.513

High

1393102

FLVC1
Choline/ethanolamine transporter FLVCR1

1

0

High-throughput

0.513

High

248408

GDF9
Growth/differentiation factor 9

1

10

High-throughput

0.494

High

636754

PTN
Pleiotrophin

1

2

High-throughput

0.494

High

702826

5HT2C
5-hydroxytryptamine receptor 2C

1

4

High-throughput

0.494

High

885365

HXA1
Homeobox protein Hox-A1

1

18

High-throughput

0.494

High

1139797

SETB1
Histone-lysine N-methyltransferase SETDB1

1

2

High-throughput

0.494

High

1371235

KAT5
Histone acetyltransferase KAT5

1

3

High-throughput

0.494

High

1393075

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

10

High-throughput

0.494

High

49465

TM223
Transmembrane protein 223

1

1

High-throughput

0.489

High

49685

T120B
Transmembrane protein 120B

1

2

High-throughput

0.489

High

143970

EST2
Cocaine esterase

1

5

High-throughput

0.489

High

209809

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

1

High-throughput

0.489

High

223642

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

1

High-throughput

0.489

High

223749

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

1

High-throughput

0.489

High

270674

ATP9A
Probable phospholipid-transporting ATPase IIA

1

1

High-throughput

0.489

High

321024

SUN1
SUN domain-containing protein 1

1

1

High-throughput

0.489

High

328391

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

1

High-throughput

0.489

High

337798

SGPL1
Sphingosine-1-phosphate lyase 1

1

1

High-throughput

0.489

High

397612

NU1M
NADH-ubiquinone oxidoreductase chain 1

1

1

High-throughput

0.489

High

397696

NU4M
NADH-ubiquinone oxidoreductase chain 4

1

3

High-throughput

0.489

High

397752

NU5M
NADH-ubiquinone oxidoreductase chain 5

1

3

High-throughput

0.489

High

728880

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

855376

5HT3A
5-hydroxytryptamine receptor 3A

1

4

High-throughput

0.489

High

1023440

AT8B2
Phospholipid-transporting ATPase ID

1

1

High-throughput

0.489

High

1055138

CCG1
Voltage-dependent calcium channel gamma-1 subunit

1

1

High-throughput

0.489

High

1155137

SCN9A
Sodium channel protein type 9 subunit alpha

1

9

High-throughput

0.489

High

1164350

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

1

High-throughput

0.489

High

1187370

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

1

High-throughput

0.489

High

1198939

ORML2
ORM1-like protein 2

1

2

High-throughput

0.489

High

1203425

AG10A
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

1

2

High-throughput

0.489

High

1205389

AG10B
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

1

2

High-throughput

0.489

High

1210407

MANEA
Glycoprotein endo-alpha-1,2-mannosidase

1

1

High-throughput

0.489

High

1231184

TRI68
E3 ubiquitin-protein ligase TRIM68

1

3

High-throughput

0.489

High

1274086

MOT13
Monocarboxylate transporter 13

1

7

High-throughput

0.489

High

1322828

ORML3
ORM1-like protein 3

1

2

High-throughput

0.489

High

1327712

MACOI
Macoilin

1

1

High-throughput

0.489

High

1337907

ZNT7
Zinc transporter 7

1

7

High-throughput

0.489

High

1353707

MOT10
Monocarboxylate transporter 10

1

7

High-throughput

0.489

High

1382715

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.489

High

1382908

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.489

High

1386253

TLCD1
TLC domain-containing protein 1

1

2

High-throughput

0.489

High

1393067

S2533
Solute carrier family 25 member 33

1

2

High-throughput

0.489

High

1393071

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

2

High-throughput

0.489

High

1393078

S22A4
Solute carrier family 22 member 4

1

3

High-throughput

0.489

High

1393084

CP26B
Cytochrome P450 26B1

1

1

High-throughput

0.489

High

1393092

ORML1
ORM1-like protein 1

1

2

High-throughput

0.489

High

1393096

POMT2
Protein O-mannosyl-transferase 2

1

3

High-throughput

0.489

High

1393099

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

1

High-throughput

0.489

High

1393100

BCS1
Mitochondrial chaperone BCS1

1

2

High-throughput

0.489

High

845468

PE2R3
Prostaglandin E2 receptor EP3 subtype

1

3

High-throughput

0.479

High

1113991

CUL3
Cullin-3

1

20

High-throughput

0.479

High

880949

MTR1B
Melatonin receptor type 1B

1

3

High-throughput

0.464

High

1328619

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

0

High-throughput

0.458

High

1098832

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

3

Small-scale

0.457

High

923431

SC5A3
Sodium/myo-inositol cotransporter

1

1

High-throughput

0.445

High

1131595

MFS10
Major facilitator superfamily domain-containing protein 10

1

7

High-throughput

0.445

High

1236274

MFSD5
Molybdate-anion transporter

1

2

High-throughput

0.445

High

1251173

ZNT10
Calcium/manganese antiporter SLC30A10

1

7

High-throughput

0.445

High

1312968

S35F2
Solute carrier family 35 member F2

1

2

High-throughput

0.445

High

1393074

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

5

High-throughput

0.445

High

1393081

ZN408
Zinc finger protein 408

1

20

High-throughput

0.439

High

964414

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.438

High

1103019

CENPR
Centromere protein R

1

0

High-throughput

0.438

High

218623

TGON2
Trans-Golgi network integral membrane protein 2

1

19

High-throughput

0.437

High

506641

GPHRB
Golgi pH regulator B

1

3

High-throughput

0.437

High

983933

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

High-throughput

0.437

High

1004966

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.437

High

1249113

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1309760

CTL2
Choline transporter-like protein 2

1

0

High-throughput

0.426

High

770745

ADA1A
Alpha-1A adrenergic receptor

1

3

Small-scale

0.417

High

85390

GPHRA
Golgi pH regulator A

1

3

High-throughput

0.407

High

1340553

MFSD8
Major facilitator superfamily domain-containing protein 8

1

6

High-throughput

0.407

High

1361286

CTR3
Cationic amino acid transporter 3

1

3

High-throughput

0.407

High

939819

ATPK
ATP synthase F(0) complex subunit f, mitochondrial

1

0

High-throughput

0.282

High

1122760

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.282

High

1272519

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.282

High

184212

RER1
Protein RER1

1

0

High-throughput

0.279

Low

225383

ERD23
ER lumen protein-retaining receptor 3

1

0

High-throughput

0.279

Low

278719

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.279

Low

326482

NDUB6
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6

1

0

High-throughput

0.279

Low

328567

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.279

Low

333592

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

1

0

High-throughput

0.279

Low

462801

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.279

Low

605480

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

High-throughput

0.279

Low

940045

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.279

Low

1070177

NTCP7
Sodium/bile acid cotransporter 7

1

0

High-throughput

0.279

Low

1091968

SEC20
Vesicle transport protein SEC20

1

0

High-throughput

0.279

Low

1191933

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.279

Low

1209987

TM201
Transmembrane protein 201

1

0

High-throughput

0.279

Low

1238673

TM214
Transmembrane protein 214

1

0

High-throughput

0.279

Low

1238889

MFS12
Major facilitator superfamily domain-containing protein 12

1

0

High-throughput

0.279

Low

1241157

LTMD1
LETM1 domain-containing protein 1

1

0

High-throughput

0.279

Low

1260313

INT8
Integrator complex subunit 8

1

0

High-throughput

0.279

Low

1270605

COX15
Heme A synthase COX15

1

0

High-throughput

0.279

Low

1281022

PIGW
Glucosaminyl-phosphatidylinositol-acyltransferase PIGW

1

0

High-throughput

0.279

Low

1329510

FITM2
Acyl-coenzyme A diphosphatase FITM2

1

0

High-throughput

0.279

Low

1337212

MCU
Calcium uniporter protein, mitochondrial

1

0

High-throughput

0.279

Low

1363516

PIEZ1
Piezo-type mechanosensitive ion channel component 1

1

0

High-throughput

0.279

Low

1366709

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

0

High-throughput

0.279

Low

1381801

MARC2
Mitochondrial amidoxime reducing component 2

1

0

High-throughput

0.279

Low

1384178

TM186
Transmembrane protein 186

1

0

High-throughput

0.279

Low

1384743

ANKR9
Ankyrin repeat domain-containing protein 9

1

0

High-throughput

0.279

Low

1393072

SGPP1
Sphingosine-1-phosphate phosphatase 1

1

0

High-throughput

0.279

Low

1393089

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.279

Low

1393090

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

1393093

TM14C
Transmembrane protein 14C

1

0

High-throughput

0.279

Low

1393095

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.279

Low

1393098

DOLK
Dolichol kinase

1

0

High-throughput

0.279

Low

1393104

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

1393105

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.279

Low

622247

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.268

Low

941238

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.251

Low

1291455

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025