Protein: MP2K6
Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)

Gene: MP2K6, MAP2K6
Organism: Homo sapiens
Interactions: 58
UniProt ID: P52564

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001649 - osteoblast differentiation
GO:0001934 - positive regulation of protein phosphorylation
GO:0002931 - response to ischemia
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

201274

M3K7
Mitogen-activated protein kinase kinase kinase 7

23

20

Small-scale

0.990

High

854732

MK14
Mitogen-activated protein kinase 14

10

20

Small-scale

0.979

High

854738

M3K5
Mitogen-activated protein kinase kinase kinase 5

9

18

Small-scale

0.969

High

854749

M3K4
Mitogen-activated protein kinase kinase kinase 4

6

16

Small-scale

0.952

High

805367

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

5

17

High-throughput

0.929

High

854734

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

20

Small-scale

0.825

High

854719

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

2

18

Small-scale

0.812

High

854720

MK12
Mitogen-activated protein kinase 12

2

20

Small-scale

0.799

High

854746

TAOK2
Serine/threonine-protein kinase TAO2

1

20

Small-scale

0.785

High

585426

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

20

Small-scale

0.724

High

854733

CDC37
Hsp90 co-chaperone Cdc37

1

11

High-throughput

0.691

High

854742

PAK6
Serine/threonine-protein kinase PAK 6

1

19

High-throughput

0.691

High

854731

PKN1
Serine/threonine-protein kinase N1

1

17

Small-scale

0.665

High

179931

TLR3
Toll-like receptor 3

1

3

Small-scale

0.647

High

349208

RASH
GTPase HRas

1

19

High-throughput

0.647

High

373917

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.647

High

542840

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.647

High

607927

FGFR4
Fibroblast growth factor receptor 4

1

19

High-throughput

0.647

High

658863

MK01
Mitogen-activated protein kinase 1

1

20

Small-scale

0.647

High

665178

EPHA2
Ephrin type-A receptor 2

1

17

High-throughput

0.647

High

673045

CCND2
G1/S-specific cyclin-D2

1

19

High-throughput

0.647

High

681750

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

High-throughput

0.647

High

728595

PPM1A
Protein phosphatase 1A

1

11

Small-scale

0.647

High

790918

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

20

High-throughput

0.647

High

800972

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

18

Small-scale

0.647

High

824618

MAPK2
MAP kinase-activated protein kinase 2

1

14

Small-scale

0.647

High

854725

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

18

High-throughput

0.647

High

854729

STK11
Serine/threonine-protein kinase STK11

1

18

High-throughput

0.647

High

854740

GLIS2
Zinc finger protein GLIS2

1

13

High-throughput

0.647

High

854744

RASF1
Ras association domain-containing protein 1

1

20

High-throughput

0.647

High

854745

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

17

Small-scale

0.647

High

854724

DUS4
Dual specificity protein phosphatase 4

1

8

High-throughput

0.618

High

854741

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

854743

PICK1
PRKCA-binding protein

2

5

High-throughput

0.606

High

854730

NF2L2
Nuclear factor erythroid 2-related factor 2

1

6

Small-scale

0.603

High

344956

CYTN
Cystatin-SN

1

1

High-throughput

0.536

High

820288

SPB4
Serpin B4

1

4

High-throughput

0.536

High

854723

PLCB2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

1

2

Small-scale

0.515

High

854728

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

854739

CDCA4
Cell division cycle-associated protein 4

1

0

High-throughput

0.513

High

776272

MLH1
DNA mismatch repair protein Mlh1

1

3

Small-scale

0.508

High

854726

DCTN1
Dynactin subunit 1

1

20

Small-scale

0.506

High

536129

HGF
Hepatocyte growth factor

1

4

High-throughput

0.501

High

854727

BECN1
Beclin-1

1

3

High-throughput

0.501

High

854747

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

167345

SMAD7
Mothers against decapentaplegic homolog 7

1

17

Small-scale

0.479

High

359786

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.479

High

394376

A4
Amyloid-beta precursor protein

1

9

Small-scale

0.479

High

683219

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

854721

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

Small-scale

0.479

High

854722

RACK1
Small ribosomal subunit protein RACK1

1

15

Small-scale

0.479

High

854735

FBX31
F-box only protein 31

1

1

Small-scale

0.479

High

854736

CARM1
Histone-arginine methyltransferase CARM1

1

5

High-throughput

0.479

High

854748

TRAF6
TNF receptor-associated factor 6

1

14

Small-scale

0.479

High

281575

WFS1
Wolframin

1

1

High-throughput

0.470

High

854737

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.458

High

362459

C1QA
Complement C1q subcomponent subunit A

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024