Protein: CERS4
Ceramide synthase 4 (CerS4) (EC 2.3.1.-) (LAG1 longevity assurance homolog 4) (Sphingosine N-acyltransferase CERS4) (EC 2.3.1.24)

Gene: CERS4
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q9HA82

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005789 - endoplasmic reticulum membrane
GO:0030148 - sphingolipid biosynthetic process
GO:0046513 - ceramide biosynthetic process
GO:0050291 - sphingosine N-acyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1251752

CERS6
Ceramide synthase 6

1

7

High-throughput

0.691

High

360122

NB5R3
NADH-cytochrome b5 reductase 3

2

1

High-throughput

0.606

High

1050062

PLP2
Proteolipid protein 2

2

1

High-throughput

0.606

High

1437473

IR3IP
Immediate early response 3-interacting protein 1

2

1

High-throughput

0.606

High

144491

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

1216451

TSPO2
Translocator protein 2

2

0

High-throughput

0.580

High

1328202

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

1329667

SERP2
Stress-associated endoplasmic reticulum protein 2

2

0

High-throughput

0.580

High

1379882

FATE1
Fetal and adult testis-expressed transcript protein

2

0

High-throughput

0.580

High

1437470

NAT8
N-acetyltransferase 8

2

0

High-throughput

0.580

High

1437474

TX264
Testis-expressed protein 264

2

0

High-throughput

0.580

High

1436638

IPPK
Inositol-pentakisphosphate 2-kinase

2

3

High-throughput

0.574

High

189851

STX7
Syntaxin-7

2

1

High-throughput

0.553

High

295708

UPK1B
Uroplakin-1b

2

5

High-throughput

0.553

High

722624

CTR1
High affinity cationic amino acid transporter 1

2

8

High-throughput

0.553

High

849039

PTN9
Tyrosine-protein phosphatase non-receptor type 9

2

4

High-throughput

0.553

High

1007416

S35A1
CMP-sialic acid transporter

2

1

High-throughput

0.553

High

1324759

S35F6
Solute carrier family 35 member F6

2

8

High-throughput

0.553

High

1334432

CLC1A
C-type lectin domain family 1 member A

2

4

High-throughput

0.553

High

1351762

GP151
G-protein coupled receptor 151

2

6

High-throughput

0.553

High

1405026

NEUR1
Sialidase-1

2

1

High-throughput

0.553

High

1434641

SG196
Protein O-mannose kinase

1

4

High-throughput

0.536

High

403225

APOB
Apolipoprotein B-100

1

0

High-throughput

0.513

High

1155269

VAS1
V-type proton ATPase subunit S1

1

0

High-throughput

0.513

High

141871

ACKR2
Atypical chemokine receptor 2

1

11

High-throughput

0.489

High

640471

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

19

High-throughput

0.489

High

1205038

RABL3
Rab-like protein 3

1

1

High-throughput

0.489

High

1366246

LPAR1
Lysophosphatidic acid receptor 1

1

12

High-throughput

0.489

High

1432418

TTYH1
Protein tweety homolog 1

1

3

High-throughput

0.489

High

1437468

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

1

High-throughput

0.489

High

430375

JUN
Transcription factor Jun

1

2

High-throughput

0.479

High

951438

SC61B
Protein transport protein Sec61 subunit beta

1

4

High-throughput

0.479

High

1390454

Q96FB2
SLC29A2 protein

1

3

High-throughput

0.470

High

1196830

TM119
Transmembrane protein 119

1

0

High-throughput

0.460

High

1430960

UN93B
Protein unc-93 homolog B1

1

3

High-throughput

0.445

High

1127897

S29A2
Equilibrative nucleoside transporter 2

1

3

High-throughput

0.439

High

1437469

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.437

High

256157

S19A2
Thiamine transporter 1

1

5

High-throughput

0.407

High

351255

MOT3
Monocarboxylate transporter 3

1

2

High-throughput

0.407

High

1236325

MFSD5
Molybdate-anion transporter

1

3

High-throughput

0.407

High

1242232

NPAL3
NIPA-like protein 3

1

3

High-throughput

0.407

High

1337959

ZNT7
Zinc transporter 7

1

6

High-throughput

0.407

High

49754

TMM72
Transmembrane protein 72

2

0

High-throughput

0.316

High

297319

SERF1
Small EDRK-rich factor 1

2

0

High-throughput

0.316

High

539497

ITAM
Integrin alpha-M

2

0

High-throughput

0.316

High

549464

CD20
B-lymphocyte antigen CD20

2

0

High-throughput

0.316

High

666024

IBP5
Insulin-like growth factor-binding protein 5

2

0

High-throughput

0.316

High

712128

CO4A5

2

0

High-throughput

0.316

High

895065

EMD
Emerin

2

0

High-throughput

0.316

High

928877

LIPR1
Inactive pancreatic lipase-related protein 1

2

0

High-throughput

0.316

High

946386

SIM11
Small integral membrane protein 11

2

0

High-throughput

0.316

High

989383

VAMP2
Vesicle-associated membrane protein 2

2

0

High-throughput

0.316

High

1195551

CTXN3
Cortexin-3

2

0

High-throughput

0.316

High

1295798

C1QL4
Complement C1q-like protein 4

2

0

High-throughput

0.316

High

1340714

CC4L
C-C motif chemokine 4-like

2

0

High-throughput

0.316

High

1346727

SCAM5
Secretory carrier-associated membrane protein 5

2

0

High-throughput

0.316

High

1347204

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

0

High-throughput

0.316

High

1349019

TM254
Transmembrane protein 254

2

0

High-throughput

0.316

High

1384084

TOM6
Mitochondrial import receptor subunit TOM6 homolog

2

0

High-throughput

0.316

High

1393360

T176A
Transmembrane protein 176A

2

0

High-throughput

0.316

High

1430273

FXYD6
FXYD domain-containing ion transport regulator 6

2

0

High-throughput

0.316

High

1437471

S13A4
Solute carrier family 13 member 4

2

0

High-throughput

0.316

High

1437472

STX8
Syntaxin-8

2

0

High-throughput

0.316

High

718734

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

High-throughput

0.251

Low

1431621

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025