Protein: VMA21
Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein)

Gene: VMA21
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q3ZAQ7

Gene Ontology (top 5):
GO:0005764 - lysosome
GO:0005789 - endoplasmic reticulum membrane
GO:0012507 - ER to Golgi transport vesicle membrane
GO:0033116 - endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0043462 - regulation of ATP-dependent activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

692202

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

2

1

High-throughput

0.726

High

1191793

VATO
V-type proton ATPase 21 kDa proteolipid subunit c''

2

1

High-throughput

0.700

High

292646

RENR
Renin receptor

4

0

Small-scale

0.664

High

1191787

EDA
Ectodysplasin-A

3

0

High-throughput

0.638

High

1191817

VPP2
V-type proton ATPase 116 kDa subunit a 2

3

3

High-throughput

0.609

High

1191775

VMA12
Vacuolar ATPase assembly protein VMA12

2

0

High-throughput

0.602

High

144435

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

162209

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

0

High-throughput

0.580

High

325552

YIF1A
Protein YIF1A

2

0

High-throughput

0.580

High

719934

HMOX2
Heme oxygenase 2

2

0

High-throughput

0.580

High

1091927

SEC20
Vesicle transport protein SEC20

2

0

High-throughput

0.580

High

1139202

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

2

0

High-throughput

0.580

High

1191801

AT131
Endoplasmic reticulum transmembrane helix translocase

2

0

High-throughput

0.580

High

1191804

TECR
Very-long-chain enoyl-CoA reductase

2

0

High-throughput

0.580

High

1191807

ORML1
ORM1-like protein 1

2

0

High-throughput

0.580

High

1191820

INSI2
Insulin-induced gene 2 protein

2

0

High-throughput

0.580

High

961528

VA0D1
V-type proton ATPase subunit d 1

2

1

High-throughput

0.558

High

1191776

VA0D2
V-type proton ATPase subunit d 2

2

1

High-throughput

0.558

High

1177801

CL12B
C-type lectin domain family 12 member B

2

1

High-throughput

0.553

High

1191782

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

1

High-throughput

0.553

High

1191814

PLLP
Plasmolipin

2

1

High-throughput

0.553

High

698715

CALX
Calnexin

1

0

High-throughput

0.513

High

888885

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

932574

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

0

High-throughput

0.513

High

1053800

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.513

High

1191771

CERS3
Ceramide synthase 3

1

0

High-throughput

0.513

High

1191785

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.513

High

1191808

AT10D
Phospholipid-transporting ATPase VD

1

0

High-throughput

0.513

High

1106781

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

3

High-throughput

0.489

High

1191767

LHPL2
LHFPL tetraspan subfamily member 2 protein

1

1

High-throughput

0.489

High

1191774

CKLF8
CKLF-like MARVEL transmembrane domain-containing protein 8

1

1

High-throughput

0.489

High

1191788

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

3

High-throughput

0.489

High

1191800

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

3

High-throughput

0.489

High

1191811

CLC4A
C-type lectin domain family 4 member A

1

2

High-throughput

0.489

High

48647

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

466290

RHOC
Rho-related GTP-binding protein RhoC

1

2

High-throughput

0.479

High

581086

RAC2
Ras-related C3 botulinum toxin substrate 2

1

2

High-throughput

0.479

High

1015484

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

1191794

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1065902

Q08AM2
ADAM33 protein

1

1

High-throughput

0.470

High

380052

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

418174

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

901273

RAB7A
Ras-related protein Rab-7a

1

0

High-throughput

0.458

High

1125465

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1191761

MKS3
Meckelin

1

0

High-throughput

0.458

High

1191779

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

1191797

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1191795

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

1

High-throughput

0.439

High

1191764

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1191772

MIRO2
Mitochondrial Rho GTPase 2

1

3

High-throughput

0.437

High

1191784

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1191790

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1191773

K2013
Uncharacterized protein KIAA2013

3

0

High-throughput

0.345

High

1191789

S2546
Mitochondrial outer membrane protein SLC25A46

3

0

High-throughput

0.340

High

186473

VA0E1
V-type proton ATPase subunit e 1

2

0

High-throughput

0.328

High

1159066

C3AR
C3a anaphylatoxin chemotactic receptor

2

0

High-throughput

0.328

High

1191809

CTNA3
Catenin alpha-3

2

0

High-throughput

0.328

High

350370

ABHGA
Phosphatidylserine lipase ABHD16A

2

0

High-throughput

0.316

High

989341

VAMP2
Vesicle-associated membrane protein 2

2

0

High-throughput

0.316

High

1108903

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

1191762

RTP2
Receptor-transporting protein 2

2

0

High-throughput

0.316

High

1191763

S35E4
Solute carrier family 35 member E4

2

0

High-throughput

0.316

High

1191765

NPAL3
NIPA-like protein 3

2

0

High-throughput

0.316

High

1191766

TM107
Transmembrane protein 107

2

0

High-throughput

0.316

High

1191798

TMM60
Transmembrane protein 60

2

0

High-throughput

0.316

High

1191805

NINJ2
Ninjurin-2

2

0

High-throughput

0.316

High

1191813

THS7A
Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]

2

0

High-throughput

0.316

High

1191818

DGLA
Diacylglycerol lipase-alpha

2

0

High-throughput

0.316

High

1191819

YIPF1
Protein YIPF1

2

0

High-throughput

0.316

High

1191777

S43A3
Equilibrative nucleobase transporter 1

2

0

High-throughput

0.313

High

820556

GPV
Platelet glycoprotein V

1

0

High-throughput

0.279

Low

870822

GLRB
Glycine receptor subunit beta

1

0

High-throughput

0.279

Low

945926

OR4D2
Olfactory receptor 4D2

1

0

High-throughput

0.279

Low

946381

SIM11
Small integral membrane protein 11

1

0

High-throughput

0.279

Low

1015035

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.279

Low

1164243

VATF
V-type proton ATPase subunit F

1

0

High-throughput

0.279

Low

1167046

ECSCR
Endothelial cell-specific chemotaxis regulator

1

0

High-throughput

0.279

Low

1191780

T185A
Transmembrane protein 185A

1

0

High-throughput

0.279

Low

1191786

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.279

Low

1191796

METL9
Protein-L-histidine N-pros-methyltransferase

1

0

High-throughput

0.279

Low

1191810

PILRB
Paired immunoglobulin-like type 2 receptor beta

1

0

High-throughput

0.279

Low

1191812

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

337293

CXB6
Gap junction beta-6 protein

1

0

High-throughput

0.269

Low

1191781

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.251

Low

106042

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

218254

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

611153

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.249

Low

820656

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.249

Low

822696

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.249

Low

947204

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.249

Low

1004644

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1122500

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.249

Low

1163348

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

1191768

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.249

Low

1191769

LBN
Limbin

1

0

High-throughput

0.249

Low

1191770

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1191778

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.249

Low

1191792

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1191802

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1191803

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1191806

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

1191815

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.249

Low

1191816

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.249

Low

337100

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.232

Low

627347

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

0

High-throughput

0.232

Low

720392

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

0

High-throughput

0.232

Low

1191783

MOT10
Monocarboxylate transporter 10

1

0

High-throughput

0.232

Low

1191791

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.232

Low

1191799

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025