Protein: NKG2C
NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c)

Gene: NKG2C, KLRC2
Organism: Homo sapiens
Interactions: 47
UniProt ID: P26717

Gene Ontology (top 5):
GO:0002223 - stimulatory C-type lectin receptor signaling pathway
GO:0002228 - natural killer cell mediated immunity
GO:0002250 - adaptive immune response
GO:0004888 - transmembrane signaling receptor activity
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

688661

KLRD1
Natural killer cells antigen CD94

5

16

Small-scale

0.909

High

688524

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

18

High-throughput

0.691

High

688677

HMR1
Major histocompatibility complex class I-related protein 1

1

20

High-throughput

0.691

High

568037

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

20

Small-scale

0.618

High

688659

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

20

Small-scale

0.618

High

230941

TYOBP
TYRO protein tyrosine kinase-binding protein

2

3

Small-scale

0.584

High

243786

ADCY3
Adenylate cyclase type 3

1

1

High-throughput

0.536

High

688655

CALX
Calnexin

1

20

High-throughput

0.536

High

688656

AT12A
Potassium-transporting ATPase alpha chain 2

1

9

High-throughput

0.536

High

688658

CXCR4
C-X-C chemokine receptor type 4

1

3

High-throughput

0.536

High

688662

MTR1L
Melatonin-related receptor

1

6

High-throughput

0.536

High

688663

FZD2
Frizzled-2

1

4

High-throughput

0.536

High

688664

GAS6
Growth arrest-specific protein 6

1

14

High-throughput

0.536

High

688665

PON2
Serum paraoxonase/arylesterase 2

1

4

High-throughput

0.536

High

688672

GLT13
Polypeptide N-acetylgalactosaminyltransferase 13

1

14

High-throughput

0.536

High

688674

SIDT2
SID1 transmembrane family member 2

1

3

High-throughput

0.536

High

688678

S47A1
Multidrug and toxin extrusion protein 1

1

4

High-throughput

0.536

High

688680

ABCA3
Phospholipid-transporting ATPase ABCA3

1

6

High-throughput

0.536

High

688681

S1PR5
Sphingosine 1-phosphate receptor 5

1

12

High-throughput

0.536

High

688683

PIGU
GPI-anchor transamidase component PIGU

1

2

High-throughput

0.536

High

688687

CNNM1
Metal transporter CNNM1

1

5

High-throughput

0.536

High

688690

XCT
Cystine/glutamate transporter

1

11

High-throughput

0.536

High

688691

LRP12
Low-density lipoprotein receptor-related protein 12

1

12

High-throughput

0.536

High

688666

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

1

0

High-throughput

0.513

High

170667

CLGN
Calmegin

1

20

High-throughput

0.489

High

186320

RA51B
DNA repair protein RAD51 homolog 2

1

1

High-throughput

0.489

High

226472

SNG3
Synaptogyrin-3

1

1

High-throughput

0.489

High

683713

PTX3
Pentraxin-related protein PTX3

1

3

High-throughput

0.489

High

688660

TMM62
Transmembrane protein 62

1

3

High-throughput

0.489

High

688667

TBB8
Tubulin beta-8 chain

1

5

High-throughput

0.489

High

688668

PIGG
GPI ethanolamine phosphate transferase 2, catalytic subunit

1

6

High-throughput

0.489

High

688669

DIK1A
Divergent protein kinase domain 1A

1

5

High-throughput

0.489

High

688670

ACD10
Acyl-CoA dehydrogenase family member 10

1

2

High-throughput

0.489

High

688675

PXYP1
2-phosphoxylose phosphatase 1

1

4

High-throughput

0.489

High

688676

PIGB
GPI alpha-1,2-mannosyltransferase 3

1

4

High-throughput

0.489

High

688679

TM87B
Transmembrane protein 87B

1

1

High-throughput

0.489

High

688682

PIGM
GPI alpha-1,4-mannosyltransferase I, catalytic subunit

1

1

High-throughput

0.489

High

688684

NSUN3
tRNA

1

1

High-throughput

0.489

High

688685

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

4

High-throughput

0.489

High

688686

K1586
E3 SUMO-protein ligase KIAA1586

1

2

High-throughput

0.489

High

688688

TM39A
Transmembrane protein 39A

1

2

High-throughput

0.489

High

688689

DD19B
ATP-dependent RNA helicase DDX19B

1

3

High-throughput

0.489

High

482327

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.282

High

462762

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.279

Low

688657

SIM11
Small integral membrane protein 11

1

0

High-throughput

0.279

Low

688671

SAPC2
Suppressor APC domain-containing protein 2

1

0

High-throughput

0.279

Low

688673

S35F2
Solute carrier family 35 member F2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025