Protein: STAT6
Signal transducer and activator of transcription 6 (IL-4 Stat)

Gene: STAT6
Organism: Homo sapiens
Interactions: 61
UniProt ID: P42226

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

786487

NCOA1
Nuclear receptor coactivator 1

7

10

Small-scale

0.968

High

786484

IRF4
Interferon regulatory factor 4

3

20

Small-scale

0.875

High

786472

STAT2
Signal transducer and activator of transcription 2

2

16

Small-scale

0.776

High

570493

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

17

Small-scale

0.747

High

622729

IL4RA
Interleukin-4 receptor subunit alpha

5

20

Small-scale

0.710

High

776594

STAT3
Signal transducer and activator of transcription 3

1

16

High-throughput

0.698

High

786499

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

6

High-throughput

0.698

High

176402

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

1

High-throughput

0.691

High

786469

STAT6
Signal transducer and activator of transcription 6

1

16

Small-scale

0.665

High

786471

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.665

High

786478

EP300
Histone acetyltransferase p300

3

13

Small-scale

0.656

High

616756

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.647

High

786485

NCOA2
Nuclear receptor coactivator 2

1

8

Small-scale

0.647

High

786494

CBP
CREB-binding protein

3

14

Small-scale

0.646

High

786489

SND1
Staphylococcal nuclease domain-containing protein 1

2

0

Small-scale

0.619

High

786475

IRF9
Interferon regulatory factor 9

1

20

Small-scale

0.618

High

786509

NCOA3
Nuclear receptor coactivator 3

1

8

Small-scale

0.618

High

786504

TBK1
Serine/threonine-protein kinase TBK1

1

3

Small-scale

0.586

High

786508

TRAF6
TNF receptor-associated factor 6

2

7

Small-scale

0.584

High

786480

NMI
N-myc-interactor

2

6

Small-scale

0.576

High

427481

ANXA2
Annexin A2

1

1

Small-scale

0.573

High

786496

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

1

Small-scale

0.573

High

587461

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

10

Small-scale

0.561

High

613364

SFPQ
Splicing factor, proline- and glutamine-rich

1

1

Small-scale

0.561

High

740451

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.561

High

786491

STING
Stimulator of interferon genes protein

1

4

Small-scale

0.554

High

417468

FCER2
Low affinity immunoglobulin epsilon Fc receptor

2

1

Small-scale

0.549

High

170290

TIF1A
Transcription intermediary factor 1-alpha

1

19

High-throughput

0.541

High

786473

PKNX1
Homeobox protein PKNOX1

1

1

High-throughput

0.541

High

786492

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.541

High

786498

ZN407
Zinc finger protein 407

1

1

High-throughput

0.541

High

786502

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.541

High

786481

KIF22
Kinesin-like protein KIF22

1

1

High-throughput

0.536

High

786476

CEBPZ
CCAAT/enhancer-binding protein zeta

1

0

High-throughput

0.518

High

786477

ZNF92
Zinc finger protein 92

1

0

High-throughput

0.518

High

786482

DAZP2
DAZ-associated protein 2

1

0

High-throughput

0.518

High

786500

ANKZ1
tRNA endonuclease ANKZF1

1

0

High-throughput

0.518

High

566012

INAR1
Interferon alpha/beta receptor 1

1

15

Small-scale

0.515

High

786483

PLEC
Plectin

1

4

High-throughput

0.515

High

786488

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

7

Small-scale

0.515

High

786501

FKRP
Ribitol 5-phosphate transferase FKRP

1

0

High-throughput

0.513

High

786503

POLK
DNA polymerase kappa

1

0

High-throughput

0.513

High

352920

IFNG
Interferon gamma

1

3

Small-scale

0.501

High

554847

LOX15
Polyunsaturated fatty acid lipoxygenase ALOX15

1

0

Small-scale

0.493

High

786490

MAVS
Mitochondrial antiviral-signaling protein

1

3

Small-scale

0.484

High

386249

P53
Cellular tumor antigen p53

1

3

Small-scale

0.481

High

786486

CEBPE
CCAAT/enhancer-binding protein epsilon

1

9

Small-scale

0.481

High

786507

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

271742

PRDM1
PR domain zinc finger protein 1

1

1

Small-scale

0.479

High

401578

JUN
Transcription factor Jun

1

12

Small-scale

0.479

High

501011

IRF1
Interferon regulatory factor 1

1

20

Small-scale

0.479

High

786470

CCL11
Eotaxin

1

5

Small-scale

0.479

High

786479

TIF1B
Transcription intermediary factor 1-beta

1

11

Small-scale

0.479

High

786505

UBP18
Ubl carboxyl-terminal hydrolase 18

1

7

Small-scale

0.479

High

786506

CCL26
C-C motif chemokine 26

1

5

Small-scale

0.479

High

786474

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.460

High

786495

RCN3
Reticulocalbin-3

1

1

High-throughput

0.439

High

786493

AP2C
Transcription factor AP-2 gamma

1

0

High-throughput

0.438

High

353876

IGHG4
Immunoglobulin heavy constant gamma 4

1

2

Small-scale

0.437

High

786497

VKOR1
Vitamin K epoxide reductase complex subunit 1

1

0

Small-scale

0.251

Low


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Last updated: 15 Jul 2024