Protein: TTHY
Transthyretin (ATTR) (Prealbumin) (TBPA)

Gene: TTHY, TTR
Organism: Homo sapiens
Interactions: 160
UniProt ID: P02766

Gene Ontology (top 5):
GO:0001523 - retinoid metabolic process
GO:0003105 - negative regulation of glomerular filtration
GO:0005179 - hormone activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

389774

TTHY
Transthyretin

10

6

Small-scale

0.975

High

389592

RET4
Retinol-binding protein 4

3

1

Small-scale

0.866

High

389778

A4
Amyloid-beta precursor protein

4

1

Small-scale

0.689

High

389789

ATF4
Cyclic AMP-dependent transcription factor ATF-4

3

1

High-throughput

0.666

High

389809

NPC2
NPC intracellular cholesterol transporter 2

2

0

High-throughput

0.602

High

389783

VIME
Vimentin

2

0

High-throughput

0.594

High

389869

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.593

High

389793

MT3
Metallothionein-3

1

0

Small-scale

0.569

High

389877

FEZ1
Fasciculation and elongation protein zeta-1

2

1

High-throughput

0.566

High

389801

BAG6
Large proline-rich protein BAG6

2

0

Small-scale

0.561

High

389902

ATF5
Cyclic AMP-dependent transcription factor ATF-5

2

1

High-throughput

0.553

High

389814

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

0

Small-scale

0.537

High

389791

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

High-throughput

0.536

High

389839

VWA1
von Willebrand factor A domain-containing protein 1

1

1

High-throughput

0.536

High

389873

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

1

High-throughput

0.536

High

389875

MTMR9
Myotubularin-related protein 9

1

1

High-throughput

0.536

High

389786

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

389794

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

High-throughput

0.518

High

389811

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.518

High

389817

DDR1
Epithelial discoidin domain-containing receptor 1

1

0

High-throughput

0.518

High

389827

RAGE
Advanced glycosylation end product-specific receptor

1

0

Small-scale

0.513

High

132977

MATN2
Matrilin-2

1

0

High-throughput

0.513

High

194448

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.513

High

334139

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

351641

SG1D1
Secretoglobin family 1D member 1

1

0

High-throughput

0.513

High

387191

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.513

High

389775

ALBU
Albumin

1

0

High-throughput

0.513

High

389850

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.513

High

389862

ITLN2
Intelectin-2

1

0

High-throughput

0.513

High

389796

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

1

High-throughput

0.494

High

327675

UBL3
Ubiquitin-like protein 3

1

0

High-throughput

0.493

High

389787

VATB1
V-type proton ATPase subunit B, kidney isoform

1

0

High-throughput

0.493

High

389792

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.493

High

389798

MNDA
Myeloid cell nuclear differentiation antigen

1

0

High-throughput

0.493

High

389812

H31
Histone H3.1

1

0

High-throughput

0.493

High

389816

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.493

High

389840

CNST
Consortin

1

0

High-throughput

0.493

High

389854

PALS1
Protein PALS1

1

0

High-throughput

0.493

High

389901

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.493

High

389825

I5P1
Inositol polyphosphate-5-phosphatase A

1

1

High-throughput

0.489

High

389835

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

1

High-throughput

0.489

High

389895

PHF11
PHD finger protein 11

1

1

High-throughput

0.489

High

389900

MTMR6
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

1

1

High-throughput

0.489

High

223971

GET3
ATPase GET3

1

0

High-throughput

0.486

High

343519

CPNE6
Copine-6

1

0

High-throughput

0.486

High

369572

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.486

High

389782

TNR16
Tumor necrosis factor receptor superfamily member 16

1

0

High-throughput

0.486

High

389799

KPCI
Protein kinase C iota type

1

0

High-throughput

0.486

High

389802

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.486

High

389804

F10A1
Hsc70-interacting protein

1

0

High-throughput

0.486

High

389808

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.486

High

389842

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.486

High

389879

CAB45
45 kDa calcium-binding protein

1

0

High-throughput

0.486

High

389780

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.480

High

389784

CLUS
Clusterin

1

0

Small-scale

0.480

High

389874

DERL3
Derlin-3

1

2

Small-scale

0.479

High

389882

DERL1
Derlin-1

1

2

Small-scale

0.479

High

389884

DERL2
Derlin-2

1

2

Small-scale

0.479

High

389836

OTU7B
OTU domain-containing protein 7B

1

1

High-throughput

0.470

High

389837

ESRP1
Epithelial splicing regulatory protein 1

1

1

High-throughput

0.470

High

389845

GP141
Probable G-protein coupled receptor 141

1

1

High-throughput

0.470

High

389880

WDR83
WD repeat domain-containing protein 83

1

1

High-throughput

0.470

High

389894

FEZ2
Fasciculation and elongation protein zeta-2

1

1

High-throughput

0.470

High

389806

SUMO3
Small ubiquitin-related modifier 3

1

2

High-throughput

0.464

High

389844

RAI1
Retinoic acid-induced protein 1

1

1

High-throughput

0.464

High

389887

SP110
Sp110 nuclear body protein

1

1

High-throughput

0.464

High

137907

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.458

High

377348

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

389779

CATB
Cathepsin B

1

0

Small-scale

0.458

High

389788

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

389805

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

389905

RN115
E3 ubiquitin-protein ligase RNF115

1

1

Small-scale

0.457

High

379182

IGHG1
Immunoglobulin heavy constant gamma 1

1

1

High-throughput

0.445

High

379600

IGHA1
Immunoglobulin heavy constant alpha 1

1

1

High-throughput

0.445

High

389819

SIAT6
CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

1

0

High-throughput

0.438

High

389841

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.438

High

389821

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.437

High

389847

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

1

Small-scale

0.437

High

389776

TRFE
Serotransferrin

1

0

High-throughput

0.426

High

389777

PRIO
Major prion protein

1

0

High-throughput

0.426

High

389830

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.426

High

389890

RN181
E3 ubiquitin-protein ligase RNF181

1

1

High-throughput

0.407

High

389871

SNX27
Sorting nexin-27

2

0

High-throughput

0.328

High

389886

DDX31
ATP-dependent DNA helicase DDX31

2

0

High-throughput

0.328

High

327534

ELP1
Elongator complex protein 1

2

0

High-throughput

0.323

High

389822

CHD3
Chromodomain-helicase-DNA-binding protein 3

2

0

High-throughput

0.323

High

389826

SETB1
Histone-lysine N-methyltransferase SETDB1

2

0

High-throughput

0.323

High

389795

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

0

High-throughput

0.316

High

389831

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

2

0

High-throughput

0.316

High

292417

PALM
Paralemmin-1

2

0

High-throughput

0.306

High

389815

CDR2
Cerebellar degeneration-related protein 2

1

0

High-throughput

0.299

High

389846

NECA2
N-terminal EF-hand calcium-binding protein 2

1

0

High-throughput

0.299

High

389843

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.282

High

389865

PHYIP
Phytanoyl-CoA hydroxylase-interacting protein

1

0

High-throughput

0.282

High

252499

SEP15
Selenoprotein F

1

0

High-throughput

0.279

Low

389790

CCNA2
Cyclin-A2

1

0

High-throughput

0.279

Low

389797

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

389828

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.279

Low

389838

SFXN4
Sideroflexin-4

1

0

High-throughput

0.279

Low

389856

S43A3
Equilibrative nucleobase transporter 1

1

0

High-throughput

0.279

Low

389859

RHBL4
Rhomboid-related protein 4

1

0

High-throughput

0.279

Low

389878

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

389889

LANC2
LanC-like protein 2

1

0

High-throughput

0.279

Low

389896

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.279

Low

389907

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

0

High-throughput

0.279

Low

48220

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.268

Low

389785

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.268

Low

389800

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

0

High-throughput

0.268

Low

389807

VSX2
Visual system homeobox 2

1

0

High-throughput

0.268

Low

389818

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

High-throughput

0.268

Low

389820

KIF1A
Kinesin-like protein KIF1A

1

0

High-throughput

0.268

Low

389823

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

High-throughput

0.268

Low

389832

ZXDC
Zinc finger protein ZXDC

1

0

High-throughput

0.268

Low

389833

CP100
Cilia- and flagella-associated protein 100

1

0

High-throughput

0.268

Low

389834

F135B
Protein FAM135B

1

0

High-throughput

0.268

Low

389848

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.268

Low

389849

Q86V28
AP-1 complex subunit gamma

1

0

High-throughput

0.268

Low

389851

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.268

Low

389852

Q8IXS7
SRGAP3 protein

1

0

High-throughput

0.268

Low

389853

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

High-throughput

0.268

Low

389855

MET27
Methyltransferase-like protein 27

1

0

High-throughput

0.268

Low

389857

SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2

1

0

High-throughput

0.268

Low

389858

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.268

Low

389860

TB22A
TBC1 domain family member 22A

1

0

High-throughput

0.268

Low

389861

PRUN2
Protein prune homolog 2

1

0

High-throughput

0.268

Low

389866

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

0

High-throughput

0.268

Low

389868

RN183
E3 ubiquitin-protein ligase RNF183

1

0

High-throughput

0.268

Low

389872

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

High-throughput

0.268

Low

389876

KCD15
BTB/POZ domain-containing protein KCTD15

1

0

High-throughput

0.268

Low

389883

SPY4
Protein sprouty homolog 4

1

0

High-throughput

0.268

Low

389888

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.268

Low

389898

CSN3
COP9 signalosome complex subunit 3

1

0

High-throughput

0.268

Low

389903

KLH20
Kelch-like protein 20

1

0

High-throughput

0.268

Low

389904

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.268

Low

389906

ASB3
Ankyrin repeat and SOCS box protein 3

1

0

High-throughput

0.268

Low

284912

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

0

High-throughput

0.265

Low

354199

ZBED1
E3 SUMO-protein ligase ZBED1

1

0

High-throughput

0.265

Low

389829

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

High-throughput

0.265

Low

389881

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.265

Low

389892

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.265

Low

389897

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.265

Low

389899

CTND2
Catenin delta-2

1

0

High-throughput

0.265

Low

389781

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

0

High-throughput

0.261

Low

105082

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

277244

PITX3
Pituitary homeobox 3

1

0

Small-scale

0.249

Low

389803

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

389891

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.249

Low

389864

PI3R5
Phosphoinositide 3-kinase regulatory subunit 5

1

0

High-throughput

0.238

Low

219589

B2L11
Bcl-2-like protein 11

1

0

High-throughput

0.232

Low

261053

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

286618

STX11
Syntaxin-11

1

0

High-throughput

0.232

Low

389810

ERR3
Estrogen-related receptor gamma

1

0

High-throughput

0.232

Low

389813

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.232

Low

389824

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low

389863

SELM
Selenoprotein M

1

0

High-throughput

0.232

Low

389867

C102A
Coiled-coil domain-containing protein 102A

1

0

High-throughput

0.232

Low

389870

LRCH3
DISP complex protein LRCH3

1

0

High-throughput

0.232

Low

389885

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.232

Low

389893

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025