Protein: HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)

Gene: HMCS1, HMGCS1
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q01581

Gene Ontology (top 5):
GO:0004421 - hydroxymethylglutaryl-CoA synthase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006084 - acetyl-CoA metabolic process
GO:0006629 - lipid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

965556

FSD1
Fibronectin type III and SPRY domain-containing protein 1

3

1

High-throughput

0.667

High

738745

SPB5
Serpin B5

3

0

High-throughput

0.638

High

965537

CD5R1
Cyclin-dependent kinase 5 activator 1

3

0

High-throughput

0.638

High

283272

S22A5
Organic cation/carnitine transporter 2

2

1

High-throughput

0.621

High

965554

CDK15
Cyclin-dependent kinase 15

2

0

High-throughput

0.602

High

227199

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

239331

CC14B
Dual specificity protein phosphatase CDC14B

1

0

High-throughput

0.513

High

265511

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.513

High

565910

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

686643

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

819082

LSS
Lanosterol synthase

1

0

High-throughput

0.513

High

882718

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

924279

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

0

High-throughput

0.513

High

958657

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

965533

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

965553

IL17F
Interleukin-17F

1

0

High-throughput

0.513

High

965557

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.513

High

965558

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

965561

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

965562

SPNXB
Sperm protein associated with the nucleus on the X chromosome B1

1

0

High-throughput

0.513

High

965568

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

965569

RN115
E3 ubiquitin-protein ligase RNF115

1

0

High-throughput

0.513

High

965547

PP14C
Protein phosphatase 1 regulatory subunit 14C

1

0

High-throughput

0.493

High

965543

CERS3
Ceramide synthase 3

1

1

High-throughput

0.489

High

965545

CERS5
Ceramide synthase 5

1

1

High-throughput

0.489

High

174811

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

965534

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

965535

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

965541

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

Small-scale

0.479

High

965542

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

965555

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

214219

SPOP
Speckle-type POZ protein

1

0

Small-scale

0.460

High

267230

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

Small-scale

0.458

High

344968

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

503917

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

575380

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

965544

CUL9
Cullin-9

1

0

Small-scale

0.458

High

965548

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.458

High

965549

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

965551

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

965560

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

965564

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

965566

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

496873

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

965540

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

831234

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

234070

O10H3
Olfactory receptor 10H3

3

0

High-throughput

0.347

High

307922

OR5F1
Olfactory receptor 5F1

3

0

High-throughput

0.347

High

617743

NFYA
Nuclear transcription factor Y subunit alpha

3

0

High-throughput

0.347

High

965565

MBD5
Methyl-CpG-binding domain protein 5

3

0

High-throughput

0.347

High

361852

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

0

High-throughput

0.328

High

578838

SDC1
Syndecan-1

2

0

High-throughput

0.328

High

303679

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

849532

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.279

Low

883094

DSCR6
Protein ripply3

1

0

High-throughput

0.279

Low

965536

INSL4
Early placenta insulin-like peptide

1

0

High-throughput

0.279

Low

965538

RCN1
Reticulocalbin-1

1

0

High-throughput

0.279

Low

965539

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

965546

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

965550

PIGT
GPI transamidase component PIG-T

1

0

High-throughput

0.279

Low

965552

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

965563

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

965567

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

390831

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

552519

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

650984

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720253

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

823898

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

965559

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024