Protein: ARHG3
Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN)

Gene: ARHG3, ARHGEF3
Organism: Homo sapiens
Interactions: 15
UniProt ID: Q9NR81

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0007266 - Rho protein signal transduction
GO:0035025 - positive regulation of Rho protein signal transduction
GO:0051056 - regulation of small GTPase mediated signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

572235

TRI27
Zinc finger protein RFP

5

5

High-throughput

0.722

High

962530

RHOA
Transforming protein RhoA

1

20

Small-scale

0.692

High

978332

RHOB
Rho-related GTP-binding protein RhoB

1

20

Small-scale

0.692

High

1340363

CEP70
Centrosomal protein of 70 kDa

4

0

High-throughput

0.675

High

783427

TRI23
E3 ubiquitin-protein ligase TRIM23

3

4

High-throughput

0.617

High

269391

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

1448065

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

955645

CDC42
Cell division control protein 42 homolog

1

20

Small-scale

0.590

High

928561

TERF1
Telomeric repeat-binding factor 1

2

1

High-throughput

0.553

High

909197

NEK4
Serine/threonine-protein kinase Nek4

1

13

High-throughput

0.536

High

173419

XPO1
Exportin-1

1

17

High-throughput

0.479

High

243035

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

1398518

ZDH15
Palmitoyltransferase ZDHHC15

1

1

Small-scale

0.437

High

1419195

PBX4
Pre-B-cell leukemia transcription factor 4

2

0

High-throughput

0.316

High

1386892

DDT4L
DNA damage-inducible transcript 4-like protein

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025