Protein: PBX4
Pre-B-cell leukemia transcription factor 4 (Homeobox protein PBX4)

Gene: PBX4
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9BYU1

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001654 - eye development
GO:0001741 - XY body
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

163472

MEIS2
Homeobox protein Meis2

5

19

High-throughput

0.926

High

938182

PKNX1
Homeobox protein PKNOX1

5

20

High-throughput

0.926

High

478300

HXD4
Homeobox protein Hox-D4

2

20

High-throughput

0.783

High

478721

HXB5
Homeobox protein Hox-B5

2

20

High-throughput

0.783

High

574033

HXB2
Homeobox protein Hox-B2

2

20

High-throughput

0.783

High

725109

HXC8
Homeobox protein Hox-C8

2

20

High-throughput

0.783

High

1025226

HXC5
Homeobox protein Hox-C5

2

20

High-throughput

0.783

High

1396171

PKNX2
Homeobox protein PKNOX2

3

20

High-throughput

0.768

High

318158

IPO13
Importin-13

5

1

High-throughput

0.716

High

137142

MEIS1
Homeobox protein Meis1

1

19

High-throughput

0.691

High

823912

PBX2
Pre-B-cell leukemia transcription factor 2

1

19

High-throughput

0.691

High

1406413

MEIS3
Homeobox protein Meis3

1

19

High-throughput

0.691

High

1419202

TFP11
Tuftelin-interacting protein 11

5

2

High-throughput

0.659

High

1419192

PBX4
Pre-B-cell leukemia transcription factor 4

1

20

High-throughput

0.621

High

246921

KDM1A
Lysine-specific histone demethylase 1A

2

2

High-throughput

0.606

High

352237

MBD3
Methyl-CpG-binding domain protein 3

2

2

High-throughput

0.606

High

506173

UBFL1
Upstream-binding factor 1-like protein 1

2

7

High-throughput

0.606

High

681917

RBTN2
Rhombotin-2

2

11

High-throughput

0.606

High

842990

CDN2C
Cyclin-dependent kinase 4 inhibitor C

2

4

High-throughput

0.606

High

853846

MK09
Mitogen-activated protein kinase 9

2

4

High-throughput

0.606

High

1068927

RIPP1
Protein ripply1

2

2

High-throughput

0.606

High

1215246

RIPP2
Protein ripply2

2

2

High-throughput

0.606

High

1332110

EIF1A
Probable RNA-binding protein EIF1AD

2

1

High-throughput

0.606

High

1382630

MGN2
Protein mago nashi homolog 2

2

1

High-throughput

0.606

High

1392049

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

2

4

High-throughput

0.606

High

91652

HSBPL
Heat shock factor-binding protein 1-like protein 1

2

0

High-throughput

0.580

High

155801

TXND9
Thioredoxin domain-containing protein 9

2

0

High-throughput

0.580

High

832797

BCL6
B-cell lymphoma 6 protein

2

0

High-throughput

0.580

High

933888

GEM
GTP-binding protein GEM

2

0

High-throughput

0.580

High

983964

RBX1
E3 ubiquitin-protein ligase RBX1

2

0

High-throughput

0.580

High

1350356

MIPO1
Mirror-image polydactyly gene 1 protein

2

0

High-throughput

0.580

High

1411868

SLD5
DNA replication complex GINS protein SLD5

2

0

High-throughput

0.580

High

1416166

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.580

High

1419194

NEK6
Serine/threonine-protein kinase Nek6

2

0

High-throughput

0.580

High

1419199

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

1419200

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.580

High

1419204

CPNE7
Copine-7

2

0

High-throughput

0.580

High

1419205

SRTD1
SERTA domain-containing protein 1

2

0

High-throughput

0.580

High

1419208

ZN330
Zinc finger protein 330

2

0

High-throughput

0.580

High

1419211

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

2

0

High-throughput

0.580

High

131508

EIF3F
Eukaryotic translation initiation factor 3 subunit F

2

2

High-throughput

0.553

High

248777

PEPL
Periplakin

2

6

High-throughput

0.553

High

350498

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

4

High-throughput

0.553

High

907883

CLCKA
Chloride channel protein ClC-Ka

2

1

High-throughput

0.553

High

1108857

BFSP2
Phakinin

2

1

High-throughput

0.553

High

1208276

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

2

1

High-throughput

0.553

High

1208328

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

2

1

High-throughput

0.553

High

1330075

USBP1
Harmonin-binding protein USHBP1

2

6

High-throughput

0.553

High

1357743

TRI41
E3 ubiquitin-protein ligase TRIM41

2

2

High-throughput

0.553

High

1364867

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

1

High-throughput

0.553

High

1399894

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

1

High-throughput

0.553

High

1419196

PICK1
PRKCA-binding protein

2

4

High-throughput

0.553

High

1419206

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

2

1

High-throughput

0.553

High

1419207

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

3

High-throughput

0.553

High

564336

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.541

High

1419209

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

High-throughput

0.536

High

361349

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.515

High

775299

FUS
RNA-binding protein FUS

1

1

High-throughput

0.515

High

1096209

TADBP
TAR DNA-binding protein 43

1

1

High-throughput

0.515

High

1327330

ZN276
Zinc finger protein 276

1

0

High-throughput

0.513

High

843950

HD
Huntingtin

1

0

High-throughput

0.493

High

1025141

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.493

High

1419203

CRNN
Cornulin

1

1

High-throughput

0.489

High

1419193

RANB3
Ran-binding protein 3

1

1

High-throughput

0.481

High

613170

EGR1
Early growth response protein 1

1

1

Small-scale

0.479

High

872717

SOX2
Transcription factor SOX-2

1

13

High-throughput

0.479

High

46792

A0A384ME25
Epididymis secretory sperm binding protein

1

1

High-throughput

0.470

High

1031949

NC2B
Protein Dr1

1

3

High-throughput

0.470

High

1419210

TF3C3
General transcription factor 3C polypeptide 3

1

3

High-throughput

0.470

High

1369900

OSTF1
Osteoclast-stimulating factor 1

1

3

High-throughput

0.439

High

1220772

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.437

High

222192

NCK2
Cytoplasmic protein NCK2

2

0

High-throughput

0.316

High

965581

NTF2
Nuclear transport factor 2

2

0

High-throughput

0.316

High

1180818

KLH38
Kelch-like protein 38

2

0

High-throughput

0.316

High

1313693

IFT20
Intraflagellar transport protein 20 homolog

2

0

High-throughput

0.316

High

1315125

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.316

High

1347071

G45IP
Large ribosomal subunit protein mL64

2

0

High-throughput

0.316

High

1358905

SEN15
tRNA-splicing endonuclease subunit Sen15

2

0

High-throughput

0.316

High

1359128

PIHD2
PIH1 domain-containing protein 2

2

0

High-throughput

0.316

High

1419195

ARHG3
Rho guanine nucleotide exchange factor 3

2

0

High-throughput

0.316

High

1419197

CCM2L
Cerebral cavernous malformations 2 protein-like

2

0

High-throughput

0.316

High

1419198

CN119
Uncharacterized protein C14orf119

2

0

High-throughput

0.316

High

1419201

SPG21
Maspardin

2

0

High-throughput

0.316

High

130230

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.269

Low

280325

SC22B
Vesicle-trafficking protein SEC22b

1

0

High-throughput

0.269

Low

417729

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.269

Low

904104

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.269

Low

1276073

SIM15
Small integral membrane protein 15

1

0

High-throughput

0.269

Low

939429

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025