Protein: DDT4L
DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)

Gene: DDT4L, DDIT4L
Organism: Homo sapiens
Interactions: 214
UniProt ID: Q96D03

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0009968 - negative regulation of signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

974177

RUXG
Small nuclear ribonucleoprotein G

5

1

High-throughput

0.663

High

1386908

LSM7
U6 snRNA-associated Sm-like protein LSm7

4

3

High-throughput

0.637

High

225661

AAKB2
5'-AMP-activated protein kinase subunit beta-2

3

0

Small-scale

0.626

High

1136832

MO4L2
Mortality factor 4-like protein 2

3

1

High-throughput

0.616

High

290398

RFPL3
Ret finger protein-like 3

2

1

High-throughput

0.606

High

291851

STK16
Serine/threonine-protein kinase 16

2

1

High-throughput

0.606

High

506169

UBFL1
Upstream-binding factor 1-like protein 1

2

1

High-throughput

0.606

High

528319

THIO
Thioredoxin

2

1

High-throughput

0.606

High

728373

AKT1
RAC-alpha serine/threonine-protein kinase

2

1

High-throughput

0.606

High

807524

IF4A3
Eukaryotic initiation factor 4A-III

2

1

High-throughput

0.606

High

943809

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

1

High-throughput

0.606

High

987849

GRB2
Growth factor receptor-bound protein 2

2

2

High-throughput

0.606

High

1093157

STK4
Serine/threonine-protein kinase 4

2

2

High-throughput

0.606

High

1150065

MARE2
Microtubule-associated protein RP/EB family member 2

2

1

High-throughput

0.606

High

1309823

TEX14
Inactive serine/threonine-protein kinase TEX14

2

2

High-throughput

0.606

High

1338094

NAV1
Neuron navigator 1

2

2

High-throughput

0.606

High

1386882

PARVG
Gamma-parvin

2

1

High-throughput

0.606

High

1386883

NEK6
Serine/threonine-protein kinase Nek6

2

3

High-throughput

0.606

High

1386890

EXOS5
Exosome complex component RRP46

2

1

High-throughput

0.606

High

1386901

HSPB7
Heat shock protein beta-7

2

1

High-throughput

0.606

High

1386910

MARE3
Microtubule-associated protein RP/EB family member 3

2

1

High-throughput

0.606

High

1386916

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

3

High-throughput

0.606

High

1386917

NDK7
Nucleoside diphosphate kinase homolog 7

2

1

High-throughput

0.606

High

833667

NAA10
N-alpha-acetyltransferase 10

2

0

High-throughput

0.589

High

126247

ST2B1
Sulfotransferase 2B1

2

0

High-throughput

0.580

High

138397

ZN593
Zinc finger protein 593

2

0

High-throughput

0.580

High

221216

DNPH1
5-hydroxymethyl-dUMP N-hydrolase

2

0

High-throughput

0.580

High

276710

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

2

0

High-throughput

0.580

High

332176

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

2

0

High-throughput

0.580

High

336740

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.580

High

348883

CLIC3
Chloride intracellular channel protein 3

2

0

High-throughput

0.580

High

635359

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

0

High-throughput

0.580

High

637676

FLNA
Filamin-A

2

0

High-throughput

0.580

High

680978

PSA1
Proteasome subunit alpha type-1

2

0

High-throughput

0.580

High

770253

RL22
Large ribosomal subunit protein eL22

2

0

High-throughput

0.580

High

880461

RPIA
Ribose-5-phosphate isomerase

2

0

High-throughput

0.580

High

890273

FHIT
Bis(5'-adenosyl)-triphosphatase

2

0

High-throughput

0.580

High

937491

CDN2D
Cyclin-dependent kinase 4 inhibitor D

2

0

High-throughput

0.580

High

944843

PCBP3
Poly(rC)-binding protein 3

2

0

High-throughput

0.580

High

963349

PFD3
Prefoldin subunit 3

2

0

High-throughput

0.580

High

1042592

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

2

0

High-throughput

0.580

High

1096918

FADD
FAS-associated death domain protein

2

0

High-throughput

0.580

High

1109563

4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1

2

0

High-throughput

0.580

High

1218626

OTU1
Ubiquitin thioesterase OTU1

2

0

High-throughput

0.580

High

1224725

KFA
Kynurenine formamidase

2

0

High-throughput

0.580

High

1225039

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

0

High-throughput

0.580

High

1229396

DUS29
Dual specificity phosphatase 29

2

0

High-throughput

0.580

High

1234704

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

0

High-throughput

0.580

High

1281245

CATIP
Ciliogenesis-associated TTC17-interacting protein

2

0

High-throughput

0.580

High

1307697

CRLF3
Cytokine receptor-like factor 3

2

0

High-throughput

0.580

High

1324701

MT1M
Metallothionein-1M

2

0

High-throughput

0.580

High

1356754

HDAC7
Histone deacetylase 7

2

0

High-throughput

0.580

High

1360295

GEMI6
Gem-associated protein 6

2

0

High-throughput

0.580

High

1384001

EXOS8
Exosome complex component RRP43

2

0

High-throughput

0.580

High

1384656

AIDA
Axin interactor, dorsalization-associated protein

2

0

High-throughput

0.580

High

1386861

LRAT2
Protein LRATD2

2

0

High-throughput

0.580

High

1386870

DUS23
Dual specificity protein phosphatase 23

2

0

High-throughput

0.580

High

1386875

TOLIP
Toll-interacting protein

2

0

High-throughput

0.580

High

1386877

SH3L3
SH3 domain-binding glutamic acid-rich-like protein 3

2

0

High-throughput

0.580

High

1386879

BAFL
Barrier-to-autointegration factor-like protein

2

0

High-throughput

0.580

High

1386886

CABP5
Calcium-binding protein 5

2

0

High-throughput

0.580

High

1386898

I36RA
Interleukin-36 receptor antagonist protein

2

0

High-throughput

0.580

High

1386899

CPNE7
Copine-7

2

0

High-throughput

0.580

High

1386904

MLX
Max-like protein X

2

0

High-throughput

0.580

High

1386914

EXOS1
Exosome complex component CSL4

2

0

High-throughput

0.580

High

297022

CCNK
Cyclin-K

2

1

High-throughput

0.553

High

783737

ZNF76
Zinc finger protein 76

2

1

High-throughput

0.553

High

889632

CLK2
Dual specificity protein kinase CLK2

2

1

High-throughput

0.553

High

889785

CLK3
Dual specificity protein kinase CLK3

2

1

High-throughput

0.553

High

974265

LSM3
U6 snRNA-associated Sm-like protein LSm3

2

2

High-throughput

0.553

High

1192166

LEGL
Galectin-related protein

2

2

High-throughput

0.553

High

1349647

PPL13
Placental protein 13-like

2

2

High-throughput

0.553

High

1361603

SEPT1
Septin-1

2

2

High-throughput

0.553

High

1386867

SEPT5
Septin-5

2

2

High-throughput

0.553

High

1386885

HM20A
High mobility group protein 20A

2

1

High-throughput

0.553

High

1386903

SEPT3
Neuronal-specific septin-3

2

2

High-throughput

0.553

High

1224882

TENS2
Tensin-2

2

0

High-throughput

0.551

High

1095748

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.549

High

503639

TFPT
TCF3 fusion partner

1

0

High-throughput

0.536

High

258610

SH21A
SH2 domain-containing protein 1A

1

4

High-throughput

0.515

High

352723

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

1

High-throughput

0.515

High

834221

CSK
Tyrosine-protein kinase CSK

1

1

High-throughput

0.515

High

868756

LEG7
Galectin-7

1

2

High-throughput

0.515

High

1156043

ZIC1
Zinc finger protein ZIC 1

1

2

High-throughput

0.515

High

1289117

TRI74
Tripartite motif-containing protein 74

1

2

High-throughput

0.515

High

1351850

NEK7
Serine/threonine-protein kinase Nek7

1

3

High-throughput

0.515

High

1386857

NUD11
Diphosphoinositol polyphosphate phosphohydrolase 3-beta

1

1

High-throughput

0.515

High

1386912

PLAP
Phospholipase A-2-activating protein

1

1

High-throughput

0.515

High

224032

GET3
ATPase GET3

1

0

High-throughput

0.493

High

954571

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

990981

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

0

High-throughput

0.493

High

1006280

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.493

High

1053424

DEUP1
Deuterosome assembly protein 1

1

0

High-throughput

0.493

High

1085140

SCRN1
Secernin-1

1

0

High-throughput

0.493

High

1181490

EMAL3
Echinoderm microtubule-associated protein-like 3

1

0

High-throughput

0.493

High

1247826

PADI6
Inactive protein-arginine deiminase type-6

1

0

High-throughput

0.493

High

1257572

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.493

High

1292733

TRI69
E3 ubiquitin-protein ligase TRIM69

1

0

High-throughput

0.493

High

1353318

DOK4
Docking protein 4

1

0

High-throughput

0.493

High

1381630

GTPB3
5-taurinomethyluridine-[tRNA] synthase subunit GTPB3, mitochondrial

1

0

High-throughput

0.493

High

1386866

PITX2
Pituitary homeobox 2

1

0

High-throughput

0.493

High

1386872

NIBA1
Protein Niban 1

1

0

High-throughput

0.493

High

1386876

CARD9
Caspase recruitment domain-containing protein 9

1

0

High-throughput

0.493

High

1386881

MYG1
MYG1 exonuclease

1

0

High-throughput

0.493

High

1386891

XPP1
Xaa-Pro aminopeptidase 1

1

0

High-throughput

0.493

High

1386897

WHRN
Whirlin

1

0

High-throughput

0.493

High

1386906

CTNA3
Catenin alpha-3

1

0

High-throughput

0.493

High

1386909

NDRG4
Protein NDRG4

1

0

High-throughput

0.493

High

1289129

TRI73
Tripartite motif-containing protein 73

1

1

High-throughput

0.481

High

164868

SH21B
SH2 domain-containing protein 1B

1

4

High-throughput

0.470

High

908714

CCNH
Cyclin-H

1

1

High-throughput

0.470

High

1083419

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

1

High-throughput

0.470

High

1124286

IF4A2
Eukaryotic initiation factor 4A-II

1

1

High-throughput

0.470

High

1187446

Q3SXR9
VCX2 protein

1

1

High-throughput

0.470

High

1290548

ZN410
Zinc finger protein 410

1

1

High-throughput

0.470

High

1386863

STAC3
SH3 and cysteine-rich domain-containing protein 3

1

1

High-throughput

0.470

High

1386900

MO4L1
Mortality factor 4-like protein 1

1

1

High-throughput

0.470

High

1386878

VCX2
Variable charge X-linked protein 2

1

1

High-throughput

0.439

High

633768

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.438

High

1278960

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

3

High-throughput

0.417

High

1386864

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.320

High

1386888

NXT2
NTF2-related export protein 2

2

0

High-throughput

0.320

High

1353644

LRC15
Leucine-rich repeat-containing protein 15

2

0

High-throughput

0.319

High

181812

EPHB6
Ephrin type-B receptor 6

2

0

High-throughput

0.316

High

280766

PR40A
Pre-mRNA-processing factor 40 homolog A

2

0

High-throughput

0.316

High

300459

KRT34
Keratin, type I cuticular Ha4

2

0

High-throughput

0.316

High

333890

ABCBB
Bile salt export pump

2

0

High-throughput

0.316

High

450342

ACBP
Acyl-CoA-binding protein

2

0

High-throughput

0.316

High

463188

YES
Tyrosine-protein kinase Yes

2

0

High-throughput

0.316

High

478151

SNRPA
U1 small nuclear ribonucleoprotein A

2

0

High-throughput

0.316

High

506790

NHLC4
NHL-repeat-containing protein 4

2

0

High-throughput

0.316

High

591428

NQO2
Ribosyldihydronicotinamide dehydrogenase [quinone]

2

0

High-throughput

0.316

High

591937

F261
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

2

0

High-throughput

0.316

High

682085

RBTN1
Rhombotin-1

2

0

High-throughput

0.316

High

700535

PSB9
Proteasome subunit beta type-9

2

0

High-throughput

0.316

High

733852

CDD
Cytidine deaminase

2

0

High-throughput

0.316

High

829127

RFC5
Replication factor C subunit 5

2

0

High-throughput

0.316

High

845388

GUC1A
Guanylyl cyclase-activating protein 1

2

0

High-throughput

0.316

High

897128

AP4A
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

2

0

High-throughput

0.316

High

922406

CRBB1
Beta-crystallin B1

2

0

High-throughput

0.316

High

939642

BID
BH3-interacting domain death agonist

2

0

High-throughput

0.316

High

940458

TCL1A
T-cell leukemia/lymphoma protein 1A

2

0

High-throughput

0.316

High

943886

M3KCL
MAP3K7 C-terminal-like protein

2

0

High-throughput

0.316

High

977144

YPEL5
Protein yippee-like 5

2

0

High-throughput

0.316

High

1013964

TXN4A
Thioredoxin-like protein 4A

2

0

High-throughput

0.316

High

1064345

PDE4C
3',5'-cyclic-AMP phosphodiesterase 4C

2

0

High-throughput

0.316

High

1093684

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.316

High

1116377

RAB32
Ras-related protein Rab-32

2

0

High-throughput

0.316

High

1123076

FHL2
Four and a half LIM domains protein 2

2

0

High-throughput

0.316

High

1140261

IF4H
Eukaryotic translation initiation factor 4H

2

0

High-throughput

0.316

High

1143003

PMVK
Phosphomevalonate kinase

2

0

High-throughput

0.316

High

1187279

ZSC23
Zinc finger and SCAN domain-containing protein 23

2

0

High-throughput

0.316

High

1193588

CE022
UPF0489 protein C5orf22

2

0

High-throughput

0.316

High

1235839

KRA56
Keratin-associated protein 5-6

2

0

High-throughput

0.316

High

1239084

CDPF1
Cysteine-rich DPF motif domain-containing protein 1

2

0

High-throughput

0.316

High

1239777

FAP20
Fanconi anemia core complex-associated protein 20

2

0

High-throughput

0.316

High

1271389

KCTD9
BTB/POZ domain-containing protein KCTD9

2

0

High-throughput

0.316

High

1271967

ZN765
Zinc finger protein 765

2

0

High-throughput

0.316

High

1280148

ARPIN
Arpin

2

0

High-throughput

0.316

High

1292429

PPR27
Protein phosphatase 1 regulatory subunit 27

2

0

High-throughput

0.316

High

1292637

NR2CA
Nuclear receptor 2C2-associated protein

2

0

High-throughput

0.316

High

1315430

P20D2
Xaa-Arg dipeptidase

2

0

High-throughput

0.316

High

1315881

F200C
Protein FAM200C

2

0

High-throughput

0.316

High

1322485

TTC5
Tetratricopeptide repeat protein 5

2

0

High-throughput

0.316

High

1324810

KDM8
Bifunctional peptidase and arginyl-hydroxylase JMJD5

2

0

High-throughput

0.316

High

1332148

SR1IP
Protein SREK1IP1

2

0

High-throughput

0.316

High

1358897

SEN15
tRNA-splicing endonuclease subunit Sen15

2

0

High-throughput

0.316

High

1358981

TEKT4
Tektin-4

2

0

High-throughput

0.316

High

1361425

MYLIP
E3 ubiquitin-protein ligase MYLIP

2

0

High-throughput

0.316

High

1370613

GPKOW
G-patch domain and KOW motifs-containing protein

2

0

High-throughput

0.316

High

1383970

ARK2N
Protein ARK2N

2

0

High-throughput

0.316

High

1385243

LENG1
Leukocyte receptor cluster member 1

2

0

High-throughput

0.316

High

1385796

COAC
Phosphopantothenoylcysteine decarboxylase

2

0

High-throughput

0.316

High

1386858

ACY3
N-acyl-aromatic-L-amino acid amidohydrolase

2

0

High-throughput

0.316

High

1386859

SC22A
Vesicle-trafficking protein SEC22a

2

0

High-throughput

0.316

High

1386868

NUD22
Uridine diphosphate glucose pyrophosphatase NUDT22

2

0

High-throughput

0.316

High

1386869

MIEN1
Migration and invasion enhancer 1

2

0

High-throughput

0.316

High

1386873

B2L14
Apoptosis facilitator Bcl-2-like protein 14

2

0

High-throughput

0.316

High

1386884

CHM1A
Charged multivesicular body protein 1a

2

0

High-throughput

0.316

High

1386887

NGB
Neuroglobin

2

0

High-throughput

0.316

High

1386889

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

0

High-throughput

0.316

High

1386893

PLS4
Phospholipid scramblase 4

2

0

High-throughput

0.316

High

1386894

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.316

High

1386895

T11L1
T-complex protein 11-like protein 1

2

0

High-throughput

0.316

High

1386896

CN119
Uncharacterized protein C14orf119

2

0

High-throughput

0.316

High

1386902

CS025
UPF0449 protein C19orf25

2

0

High-throughput

0.316

High

1386905

PUF60
Poly(U)-binding-splicing factor PUF60

2

0

High-throughput

0.316

High

1386907

SCOC
Short coiled-coil protein

2

0

High-throughput

0.316

High

1386913

MEMO1
Protein MEMO1

2

0

High-throughput

0.316

High

1386915

PPIL1
Peptidyl-prolyl cis-trans isomerase-like 1

2

0

High-throughput

0.316

High

171098

VP26C
Vacuolar protein sorting-associated protein 26C

1

0

High-throughput

0.282

High

155636

ASTN1
Astrotactin-1

1

0

High-throughput

0.268

Low

191741

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.268

Low

281237

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.268

Low

302606

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

High-throughput

0.268

Low

452363

PDIA1
Protein disulfide-isomerase

1

0

High-throughput

0.268

Low

700833

PIT1
Pituitary-specific positive transcription factor 1

1

0

High-throughput

0.268

Low

907177

SUOX
Sulfite oxidase, mitochondrial

1

0

High-throughput

0.268

Low

938261

SEC13
Protein SEC13 homolog

1

0

High-throughput

0.268

Low

952621

MYL6
Myosin light polypeptide 6

1

0

High-throughput

0.268

Low

1120693

VEZF1
Vascular endothelial zinc finger 1

1

0

High-throughput

0.268

Low

1366658

SORL
Sortilin-related receptor

1

0

High-throughput

0.268

Low

1380325

MYDGF
Myeloid-derived growth factor

1

0

High-throughput

0.268

Low

1386860

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.268

Low

1386862

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.268

Low

1386865

PRP18
Pre-mRNA-splicing factor 18

1

0

High-throughput

0.268

Low

1386871

SYTM
Threonine--tRNA ligase, mitochondrial

1

0

High-throughput

0.268

Low

1386874

NDEL1
Nuclear distribution protein nudE-like 1

1

0

High-throughput

0.268

Low

1386880

DCTP1
dCTP pyrophosphatase 1

1

0

High-throughput

0.268

Low

1386892

ARHG3
Rho guanine nucleotide exchange factor 3

1

0

High-throughput

0.268

Low

1386911

TCF19
Transcription factor 19

1

0

High-throughput

0.268

Low

1386918

EMIL1
EMILIN-1

1

0

High-throughput

0.268

Low

551192

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

1234731

CENPP
Centromere protein P

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025