Protein: RAF1
RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1)

Gene: RAF1
Organism: Mus musculus
Interactions: 34
UniProt ID: Q99N57

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001678 - intracellular glucose homeostasis
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1222734

RASH
GTPase HRas

10

20

Small-scale

0.967

High

728920

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

5

20

Small-scale

0.910

High

1222309

KSR1
Kinase suppressor of Ras 1

5

20

Small-scale

0.906

High

700376

BRAF
Serine/threonine-protein kinase B-raf

4

18

Small-scale

0.873

High

1000208

ROCK2
Rho-associated protein kinase 2

2

20

Small-scale

0.754

High

1298421

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

16

Small-scale

0.665

High

1224649

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

20

Small-scale

0.621

High

204236

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

Small-scale

0.618

High

424721

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

18

Small-scale

0.618

High

591072

KPCE
Protein kinase C epsilon type

1

12

Small-scale

0.618

High

990045

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.618

High

1190038

NEK10
Serine/threonine-protein kinase Nek10

1

20

Small-scale

0.618

High

1408906

STK3
Serine/threonine-protein kinase 3

1

20

Small-scale

0.618

High

1408910

SGK1
Serine/threonine-protein kinase Sgk1

1

20

Small-scale

0.618

High

1408911

RFXK
DNA-binding protein RFXANK

1

13

Small-scale

0.618

High

1408912

T22D3
TSC22 domain family protein 3

2

1

Small-scale

0.601

High

746565

RASK
GTPase KRas

1

20

High-throughput

0.590

High

1221445

GRB10
Growth factor receptor-bound protein 10

1

19

Small-scale

0.590

High

967123

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

1

20

Small-scale

0.575

High

1341412

RAB38
Ras-related protein Rab-38

1

11

High-throughput

0.575

High

1408907

RABX5
Rab5 GDP/GTP exchange factor

1

2

Small-scale

0.552

High

771503

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

14

High-throughput

0.536

High

595260

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

9

High-throughput

0.479

High

1000056

PEBP1
Phosphatidylethanolamine-binding protein 1

1

4

Small-scale

0.479

High

1029243

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

14

High-throughput

0.479

High

1188911

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.479

High

1217093

TNF15
Tumor necrosis factor ligand superfamily member 15

1

5

Small-scale

0.479

High

1296256

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

4

High-throughput

0.479

High

1408883

BRAP
BRCA1-associated protein

1

6

Small-scale

0.479

High

1408908

VINEX
Vinexin

1

13

Small-scale

0.479

High

1408909

SCNNB
Epithelial sodium channel subunit beta

1

1

Small-scale

0.479

High

1354127

PAXI
Paxillin

1

11

Small-scale

0.437

High

702215

LYOX
Protein-lysine 6-oxidase

1

1

Small-scale

0.407

High

1071130

KNDC1
Kinase non-catalytic C-lobe domain-containing protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025