Protein: M3K5
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)

Gene: M3K5, Map3k5
Organism: Mus musculus
Interactions: 30
UniProt ID: O35099

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0000287 - magnesium ion binding
GO:0002931 - response to ischemia
GO:0004706 - JUN kinase kinase kinase activity
GO:0004709 - MAP kinase kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

204226

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

2

9

High-throughput

0.789

High

204222

AKT1
RAC-alpha serine/threonine-protein kinase

1

18

Small-scale

0.665

High

204230

CANB1
Calcineurin subunit B type 1

1

9

Small-scale

0.653

High

204236

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.618

High

204243

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

18

Small-scale

0.618

High

204231

HDAC4
Histone deacetylase 4

1

14

High-throughput

0.536

High

204223

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.501

High

204240

RBCC1
RB1-inducible coiled-coil protein 1

1

20

Small-scale

0.501

High

204228

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

5

High-throughput

0.489

High

204245

HOME1
Homer protein homolog 1

1

10

High-throughput

0.489

High

204216

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

3

High-throughput

0.479

High

204217

DAXX
Death domain-associated protein 6

1

3

Small-scale

0.479

High

204219

THIO
Thioredoxin

1

6

Small-scale

0.479

High

204220

A4
Amyloid-beta precursor protein

1

11

Small-scale

0.479

High

204224

STING
Stimulator of interferon genes protein

1

6

High-throughput

0.479

High

204225

FBW1A
F-box/WD repeat-containing protein 1A

1

20

Small-scale

0.479

High

204227

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

20

Small-scale

0.479

High

204229

FBW1B
F-box/WD repeat-containing protein 11

1

20

Small-scale

0.479

High

204234

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

1

Small-scale

0.479

High

204235

PARK7
Parkinson disease protein 7 homolog

1

1

Small-scale

0.479

High

204241

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

20

Small-scale

0.479

High

204221

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

0

High-throughput

0.458

High

204218

CSF1
Macrophage colony-stimulating factor 1

1

4

Small-scale

0.445

High

204232

NEB2
Neurabin-2

1

18

High-throughput

0.437

High

204233

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

3

Small-scale

0.437

High

204244

STRAP
Serine-threonine kinase receptor-associated protein

1

5

Small-scale

0.437

High

204242

SRCN1
SRC kinase signaling inhibitor 1

1

0

High-throughput

0.426

High

204239

XPO7
Exportin-7

1

15

High-throughput

0.407

High

204238

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

Small-scale

0.249

Low

204237

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025