Protein: PROF1
Profilin-1 (Profilin I)

Gene: PROF1, Pfn1
Organism: Mus musculus
Interactions: 29
UniProt ID: P62962

Gene Ontology (top 5):
GO:0000774 - adenyl-nucleotide exchange factor activity
GO:0001784 - phosphotyrosine residue binding
GO:0001843 - neural tube closure
GO:0003785 - actin monomer binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

953228

ACTB
Actin, cytoplasmic 1

3

16

Small-scale

0.829

High

986966

PROF2
Profilin-2

1

0

Small-scale

0.586

High

986949

ENAH
Protein enabled homolog

1

10

Small-scale

0.501

High

986957

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

2

High-throughput

0.481

High

986958

DCA13
DDB1- and CUL4-associated factor 13

1

1

High-throughput

0.481

High

986961

Q8BQ46
TAF15 RNA polymerase II, TATA box binding protein

1

1

High-throughput

0.481

High

810510

DYN1
Dynamin-1

1

2

Small-scale

0.479

High

986948

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.479

High

986953

Q3UJF1
Histone deacetylase

1

2

High-throughput

0.479

High

986954

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

3

High-throughput

0.479

High

986959

FACD2
Fanconi anemia group D2 protein homolog

1

2

High-throughput

0.479

High

986960

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

1

High-throughput

0.479

High

986962

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

986952

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.460

High

205012

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

0

High-throughput

0.458

High

968066

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.458

High

986947

TBB5
Tubulin beta-5 chain

1

0

Small-scale

0.458

High

986950

STING
Stimulator of interferon genes protein

1

0

High-throughput

0.458

High

986955

TFE3
Transcription factor E3

1

0

High-throughput

0.458

High

986956

CLH1
Clathrin heavy chain 1

1

0

Small-scale

0.458

High

986963

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.458

High

986964

MYPOP
Myb-related transcription factor, partner of profilin

1

0

Small-scale

0.458

High

986965

EED
Polycomb protein EED

1

0

High-throughput

0.458

High

913176

STAT6
Signal transducer and transcription activator 6

1

3

High-throughput

0.457

High

986951

CBLB
E3 ubiquitin-protein ligase CBL-B

1

5

High-throughput

0.445

High

986968

HDAC5
Histone deacetylase 5

1

2

High-throughput

0.445

High

609014

HS71B
Heat shock 70 kDa protein 1B

1

3

Small-scale

0.437

High

986967

PCLO
Protein piccolo

1

1

Small-scale

0.437

High

398284

CFAD
Complement factor D

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025