Protein: PROF2
Profilin-2 (Profilin II)

Gene: PROF2, Pfn2
Organism: Mus musculus
Interactions: 23
UniProt ID: Q9JJV2

Gene Ontology (top 5):
GO:0003785 - actin monomer binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005829 - cytosol
GO:0005856 - cytoskeleton
GO:0010633 - negative regulation of epithelial cell migration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

953290

ACTB
Actin, cytoplasmic 1

3

16

Small-scale

0.834

High

810539

DYN1
Dynamin-1

2

2

Small-scale

0.646

High

1000464

VASP
Vasodilator-stimulated phosphoprotein

2

8

Small-scale

0.629

High

986966

PROF1
Profilin-1

1

0

Small-scale

0.586

High

1193959

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.536

High

313183

SYN1
Synapsin-1

1

6

Small-scale

0.479

High

1000209

ROCK2
Rho-associated protein kinase 2

1

1

Small-scale

0.479

High

1041729

ENAH
Protein enabled homolog

1

10

Small-scale

0.479

High

1225650

SYN2
Synapsin-2

1

4

Small-scale

0.479

High

1247220

NEB2
Neurabin-2

1

3

High-throughput

0.479

High

1274219

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

1

Small-scale

0.479

High

1282674

FACD2
Fanconi anemia group D2 protein homolog

1

2

High-throughput

0.479

High

1341703

WASF1
Actin-binding protein WASF1

1

5

Small-scale

0.479

High

1440872

PCLO
Protein piccolo

1

1

Small-scale

0.479

High

663190

GRIA2
Glutamate receptor 2

1

0

High-throughput

0.458

High

704302

NCKP1
Nck-associated protein 1

1

0

Small-scale

0.458

High

1362894

RHEB
GTP-binding protein Rheb

1

0

High-throughput

0.458

High

108902

G3X9H5
Huntingtin

1

2

High-throughput

0.437

High

609031

HS71B
Heat shock 70 kDa protein 1B

1

3

Small-scale

0.437

High

1191246

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

3

High-throughput

0.437

High

1296390

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

1

High-throughput

0.437

High

1424039

Q9D2V3
Progranulin

1

1

High-throughput

0.437

High

1221859

SC6A4
Sodium-dependent serotonin transporter

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025