Protein: PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1)

Gene: PLCE1
Organism: Homo sapiens
Interactions: 17
UniProt ID: Q9P212

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004435 - phosphatidylinositol-4,5-bisphosphate phospholipase C activity
GO:0004629 - phospholipase C activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

374251

RASN
GTPase NRas

1

20

High-throughput

0.698

High

374979

RASH
GTPase HRas

1

19

Small-scale

0.665

High

982139

RAP1A
Ras-related protein Rap-1A

1

19

Small-scale

0.618

High

211605

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

2

Small-scale

0.561

High

870174

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

1

1

High-throughput

0.541

High

461992

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.536

High

877027

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.513

High

1106104

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.513

High

1158580

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.513

High

414752

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

532105

KIT
Mast/stem cell growth factor receptor Kit

1

18

Small-scale

0.479

High

1307809

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.479

High

1028428

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1102120

PABP4
Polyadenylate-binding protein 4

1

0

High-throughput

0.458

High

775351

FUS
RNA-binding protein FUS

1

1

High-throughput

0.437

High

455882

H10
Histone H1.0

1

0

High-throughput

0.269

Low

1293764

PPR3B
Protein phosphatase 1 regulatory subunit 3B

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025