Protein: SIAH2
E3 ubiquitin-protein ligase SIAH2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase SIAH2) (Seven in absentia homolog 2) (Siah-2) (hSiah2)

Gene: SIAH2
Organism: Homo sapiens
Interactions: 97
UniProt ID: O43255

Gene Ontology (top 5):
GO:0003714 - transcription corepressor activity
GO:0004842 - ubiquitin-protein transferase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005769 - early endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211577

SIAH1
E3 ubiquitin-protein ligase SIAH1

4

17

Small-scale

0.910

High

211518

SIAH2
E3 ubiquitin-protein ligase SIAH2

4

16

Small-scale

0.893

High

211554

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

20

Small-scale

0.712

High

211542

SYUA
Alpha-synuclein

4

4

Small-scale

0.700

High

211556

UB2D2
Ubiquitin-conjugating enzyme E2 D2

4

20

Small-scale

0.688

High

211601

EGLN3
Prolyl hydroxylase EGLN3

3

3

Small-scale

0.678

High

211530

ANDR
Androgen receptor

3

11

Small-scale

0.656

High

211550

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

20

Small-scale

0.655

High

211603

LATS2
Serine/threonine-protein kinase LATS2

2

12

Small-scale

0.650

High

211573

SH3R1
E3 ubiquitin-protein ligase SH3RF1

2

13

Small-scale

0.644

High

211525

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

2

19

Small-scale

0.640

High

211523

PIAS1
E3 SUMO-protein ligase PIAS1

2

8

Small-scale

0.639

High

211557

UBC9
SUMO-conjugating enzyme UBC9

3

20

Small-scale

0.639

High

211597

HIPK2
Homeodomain-interacting protein kinase 2

2

17

Small-scale

0.634

High

211590

CTIP
DNA endonuclease RBBP8

2

1

Small-scale

0.629

High

211520

PRIC3
Prickle planar cell polarity protein 3

2

12

High-throughput

0.628

High

211609

SNCAP
Synphilin-1

2

8

Small-scale

0.619

High

211578

SIAH3
Seven in absentia homolog 3

1

11

Small-scale

0.618

High

211539

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

2

0

Small-scale

0.603

High

211553

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

1

Small-scale

0.602

High

211589

EGLN2
Prolyl hydroxylase EGLN2

2

3

Small-scale

0.584

High

211595

EGLN1
Egl nine homolog 1

2

3

Small-scale

0.584

High

211527

CHK2
Serine/threonine-protein kinase Chk2

1

5

Small-scale

0.578

High

211565

ASPP2
Apoptosis-stimulating of p53 protein 2

1

13

Small-scale

0.578

High

211582

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

8

Small-scale

0.578

High

211533

VAV
Proto-oncogene vav

1

4

Small-scale

0.573

High

211534

PML
Protein PML

1

12

Small-scale

0.561

High

211546

AK1C3
Aldo-keto reductase family 1 member C3

1

1

Small-scale

0.561

High

211568

ZYX
Zyxin

1

13

Small-scale

0.561

High

211586

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

20

Small-scale

0.561

High

211588

ASPP1
Apoptosis-stimulating of p53 protein 1

1

12

Small-scale

0.561

High

211605

PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

1

2

Small-scale

0.561

High

211570

NRF1
Nuclear respiratory factor 1

1

0

Small-scale

0.554

High

211579

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.554

High

211571

XAF1
XIAP-associated factor 1

1

5

Small-scale

0.552

High

211596

PEG3
Paternally-expressed gene 3 protein

1

1

Small-scale

0.552

High

211593

TINF2
TERF1-interacting nuclear factor 2

1

0

Small-scale

0.549

High

211608

TPX2
Targeting protein for Xklp2

1

0

Small-scale

0.549

High

211581

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

12

Small-scale

0.536

High

211559

PR20A
Proline-rich protein 20A

2

5

High-throughput

0.533

High

171121

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

0

Small-scale

0.529

High

211575

PEG10
Retrotransposon-derived protein PEG10

1

1

Small-scale

0.527

High

211537

OPRM
Mu-type opioid receptor

1

7

Small-scale

0.523

High

211526

LATS1
Serine/threonine-protein kinase LATS1

1

9

Small-scale

0.515

High

211545

OPRK
Kappa-type opioid receptor

1

7

Small-scale

0.515

High

211552

ATN1
Atrophin-1

1

6

High-throughput

0.508

High

211598

HIPK3
Homeodomain-interacting protein kinase 3

1

18

High-throughput

0.508

High

211558

PR20E
Proline-rich protein 20E

2

5

High-throughput

0.504

High

211551

AFF1
AF4/FMR2 family member 1

1

9

Small-scale

0.501

High

211519

SPY2
Protein sprouty homolog 2

1

5

Small-scale

0.501

High

211555

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.501

High

211563

TRAF2
TNF receptor-associated factor 2

1

18

Small-scale

0.501

High

211567

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

Small-scale

0.501

High

211610

PIAS3
E3 SUMO-protein ligase PIAS3

1

8

Small-scale

0.501

High

211572

CCBE1
Collagen and calcium-binding EGF domain-containing protein 1

1

5

High-throughput

0.494

High

211560

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

2

Small-scale

0.489

High

211607

OGDHL
2-oxoglutarate dehydrogenase-like, mitochondrial

1

2

Small-scale

0.489

High

211524

PIAS2
E3 SUMO-protein ligase PIAS2

1

8

Small-scale

0.481

High

211536

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.481

High

211543

STAT3
Signal transducer and activator of transcription 3

1

3

High-throughput

0.481

High

211547

DCC
Netrin receptor DCC

1

1

Small-scale

0.481

High

211591

MYD88
Myeloid differentiation primary response protein MyD88

1

19

High-throughput

0.481

High

211594

SETD2
Histone-lysine N-methyltransferase SETD2

1

1

High-throughput

0.481

High

168473

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

20

Small-scale

0.479

High

188109

HDAC3
Histone deacetylase 3

1

3

Small-scale

0.479

High

211521

CCNT1
Cyclin-T1

1

2

Small-scale

0.479

High

211531

BIP
Endoplasmic reticulum chaperone BiP

1

7

Small-scale

0.479

High

211535

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.479

High

211538

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

4

Small-scale

0.479

High

211540

PPARG
Peroxisome proliferator-activated receptor gamma

1

10

Small-scale

0.479

High

211541

ZEB1
Zinc finger E-box-binding homeobox 1

1

4

Small-scale

0.479

High

211548

CEBPD
CCAAT/enhancer-binding protein delta

1

2

Small-scale

0.479

High

211549

MCM2
DNA replication licensing factor MCM2

1

4

High-throughput

0.479

High

211561

ACK1
Activated CDC42 kinase 1

1

18

Small-scale

0.479

High

211562

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

211564

CUL4B
Cullin-4B

1

13

High-throughput

0.479

High

211566

FLNC
Filamin-C

1

4

Small-scale

0.479

High

211569

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.479

High

211574

SLN11
Schlafen family member 11

1

1

High-throughput

0.479

High

211576

HIPK1
Homeodomain-interacting protein kinase 1

1

18

Small-scale

0.479

High

211583

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

Small-scale

0.479

High

211584

KAT2B
Histone acetyltransferase KAT2B

1

5

Small-scale

0.479

High

211585

KAT5
Histone acetyltransferase KAT5

1

2

Small-scale

0.479

High

211592

SENP7
Sentrin-specific protease 7

1

1

Small-scale

0.479

High

211599

WNK1
Serine/threonine-protein kinase WNK1

1

4

Small-scale

0.479

High

211600

PLK3
Serine/threonine-protein kinase PLK3

1

4

Small-scale

0.479

High

211604

PD1L1
Programmed cell death 1 ligand 1

1

4

Small-scale

0.479

High

211606

TES
Testin

1

14

Small-scale

0.479

High

211528

HMOX1
Heme oxygenase 1

1

0

Small-scale

0.458

High

211532

SKI
Ski oncogene

1

0

Small-scale

0.458

High

211580

PIWL2
Piwi-like protein 2

1

0

Small-scale

0.458

High

211587

EAF2
ELL-associated factor 2

1

0

Small-scale

0.458

High

211602

CYBP
Calcyclin-binding protein

1

4

Small-scale

0.457

High

211522

NCOR1
Nuclear receptor corepressor 1

1

7

Small-scale

0.445

High

211529

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.437

High

211544

OPRD
Delta-type opioid receptor

1

7

Small-scale

0.437

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025