Protein: PYY
Peptide YY (PYY) (PYY-I) (Peptide tyrosine tyrosine) [Cleaved into: Peptide YY(3-36) (PYY-II)]

Gene: PYY
Organism: Homo sapiens
Interactions: 11
UniProt ID: P10082

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0005179 - hormone activity
GO:0005184 - neuropeptide hormone activity
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

518435

NPY1R
Neuropeptide Y receptor type 1

1

3

Small-scale

0.618

High

518437

NPY2R
Neuropeptide Y receptor type 2

1

3

Small-scale

0.553

High

518440

MEP1B
Meprin A subunit beta

1

1

Small-scale

0.501

High

518439

GUC2B
Guanylate cyclase activator 2B [Cleaved into: Guanylate cyclase C-activating peptide 2

1

0

High-throughput

0.493

High

518436

DPP4
Dipeptidyl peptidase 4

1

3

Small-scale

0.445

High

518438

SEPR
Prolyl endopeptidase FAP

1

3

Small-scale

0.445

High

518441

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.279

Low

518442

BTBD1
BTB/POZ domain-containing protein 1

1

0

High-throughput

0.279

Low

518443

XPP3
Xaa-Pro aminopeptidase 3

1

0

High-throughput

0.279

Low

518444

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

0

High-throughput

0.279

Low

226681

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025