Protein: UBP25
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)

Gene: UBP25, USP25
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q9UHP3

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508790

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

12

20

Small-scale

0.981

High

931720

RD23B
UV excision repair protein RAD23 homolog B

7

20

Small-scale

0.965

High

931614

RD23A
UV excision repair protein RAD23 homolog A

7

20

Small-scale

0.963

High

1460014

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

6

15

Small-scale

0.952

High

1402022

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

3

17

High-throughput

0.871

High

507407

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

20

High-throughput

0.811

High

1154953

NEDD8
Ubiquitin-like protein NEDD8

2

19

Small-scale

0.789

High

849268

KSYK
Tyrosine-protein kinase SYK

6

19

Small-scale

0.741

High

964497

SUMO2
Small ubiquitin-related modifier 2

5

8

Small-scale

0.721

High

1432567

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

5

6

Small-scale

0.718

High

1400463

BTBD9
BTB/POZ domain-containing protein 9

4

14

Small-scale

0.699

High

1432023

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

4

7

Small-scale

0.688

High

1114580

CUL3
Cullin-3

4

14

Small-scale

0.686

High

332458

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

3

7

Small-scale

0.684

High

724527

GDIA
Rab GDP dissociation inhibitor alpha

3

2

High-throughput

0.678

High

1361873

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

3

5

High-throughput

0.675

High

1454624

KLHL9
Kelch-like protein 9

3

13

Small-scale

0.667

High

1460017

OCTC
Peroxisomal carnitine O-octanoyltransferase

3

0

High-throughput

0.638

High

1117931

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

2

5

High-throughput

0.628

High

939239

SUMO3
Small ubiquitin-related modifier 3

2

8

Small-scale

0.619

High

1113013

CUL2
Cullin-2

2

14

Small-scale

0.611

High

1460019

MYO6
Unconventional myosin-VI

2

17

Small-scale

0.611

High

1460015

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.606

High

991455

SUMO1
Small ubiquitin-related modifier 1

2

8

Small-scale

0.602

High

1454748

KLH13
Kelch-like protein 13

2

13

Small-scale

0.584

High

1187238

PUS10
tRNA pseudouridine synthase Pus10

2

0

High-throughput

0.580

High

1245276

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

2

4

High-throughput

0.574

High

191946

MAGB4
Melanoma-associated antigen B4

1

17

High-throughput

0.573

High

1414765

ZN426
Zinc finger protein 426

1

3

High-throughput

0.573

High

1121553

KEAP1
Kelch-like ECH-associated protein 1

1

15

Small-scale

0.561

High

1027910

MYPC1
Myosin-binding protein C, slow-type

1

5

Small-scale

0.552

High

301253

RL1D1
Ribosomal L1 domain-containing protein 1

1

4

High-throughput

0.541

High

457758

TBB5
Tubulin beta chain

1

13

High-throughput

0.541

High

473162

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.541

High

685377

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.541

High

807610

IF4A3
Eukaryotic initiation factor 4A-III

1

13

High-throughput

0.541

High

929845

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.541

High

1252576

ZN841
Zinc finger protein 841

1

1

High-throughput

0.541

High

1307946

ARMC8
Armadillo repeat-containing protein 8

1

7

High-throughput

0.541

High

1404328

NP1L3
Nucleosome assembly protein 1-like 3

1

11

High-throughput

0.541

High

993798

UBC9
SUMO-conjugating enzyme UBC9

1

6

Small-scale

0.536

High

403028

ANXA1
Annexin A1

1

5

High-throughput

0.536

High

553093

PIP
Prolactin-inducible protein

1

1

High-throughput

0.536

High

902904

BLK
Tyrosine-protein kinase Blk

1

7

High-throughput

0.536

High

904443

CP2J2
Cytochrome P450 2J2

1

1

High-throughput

0.536

High

1090964

TRAF2
TNF receptor-associated factor 2

1

20

High-throughput

0.536

High

1290372

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

1

5

High-throughput

0.536

High

1365997

APBP2
Amyloid protein-binding protein 2

1

3

High-throughput

0.536

High

1390746

DYL2
Dynein light chain 2, cytoplasmic

1

2

High-throughput

0.536

High

1402264

WRIP1
ATPase WRNIP1

1

2

High-throughput

0.536

High

1429765

BTBD1
BTB/POZ domain-containing protein 1

1

14

High-throughput

0.536

High

1434417

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

High-throughput

0.536

High

996556

ACTS
Actin, alpha skeletal muscle

1

5

Small-scale

0.527

High

1240718

CDC73
Parafibromin

1

2

Small-scale

0.527

High

605838

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

6

High-throughput

0.515

High

789037

TGFR2
TGF-beta receptor type-2

1

2

High-throughput

0.515

High

1244465

DCNL2
DCN1-like protein 2

1

0

High-throughput

0.513

High

1387172

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

1088169

CNTN1
Contactin-1

1

1

Small-scale

0.512

High

1278141

MAVS
Mitochondrial antiviral-signaling protein

1

17

Small-scale

0.512

High

1454040

SENP1
Sentrin-specific protease 1

1

6

Small-scale

0.501

High

1448939

VPS45
Vacuolar protein sorting-associated protein 45

1

3

High-throughput

0.494

High

963244

LYSC
Lysozyme C

1

1

High-throughput

0.489

High

555530

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

391719

MT2
Metallothionein-2

1

1

Small-scale

0.481

High

409119

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

4

Small-scale

0.481

High

1125418

FLNC
Filamin-C

1

8

Small-scale

0.481

High

136734

TRAF5
TNF receptor-associated factor 5

1

20

Small-scale

0.479

High

423406

A4
Amyloid-beta precursor protein

1

9

Small-scale

0.479

High

535651

BIP
Endoplasmic reticulum chaperone BiP

1

10

Small-scale

0.479

High

598230

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

7

Small-scale

0.479

High

623586

RO52
E3 ubiquitin-protein ligase TRIM21

1

20

Small-scale

0.479

High

932007

EPHB4
Ephrin type-B receptor 4

1

6

High-throughput

0.479

High

951890

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

12

Small-scale

0.479

High

996887

TBA1B
Tubulin alpha-1B chain

1

9

Small-scale

0.479

High

1028437

MDM2
E3 ubiquitin-protein ligase Mdm2

1

10

Small-scale

0.479

High

1095003

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

1115481

CUL4B
Cullin-4B

1

14

High-throughput

0.479

High

1121912

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

16

Small-scale

0.479

High

1132356

GOGB1
Golgin subfamily B member 1

1

20

High-throughput

0.479

High

1161427

HIF1A
Hypoxia-inducible factor 1-alpha

1

8

Small-scale

0.479

High

1199051

KLH12
Kelch-like protein 12

1

12

Small-scale

0.479

High

1244746

KLD10
Kelch domain-containing protein 10

1

12

Small-scale

0.479

High

1255983

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1295729

HORN
Hornerin

1

8

Small-scale

0.479

High

1330968

CGAS
Cyclic GMP-AMP synthase

1

2

Small-scale

0.479

High

1365528

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.479

High

1387290

HDA11
Histone deacetylase 11

1

13

Small-scale

0.479

High

1396853

SNX27
Sorting nexin-27

1

7

High-throughput

0.479

High

1406798

BARD1
BRCA1-associated RING domain protein 1

1

10

Small-scale

0.479

High

1419764

ASPC1
Tether containing UBX domain for GLUT4

1

2

Small-scale

0.479

High

1438705

SENP2
Sentrin-specific protease 2

1

6

Small-scale

0.479

High

1448415

DUOX2
Dual oxidase 2

1

6

High-throughput

0.479

High

1460016

FEM1B
Protein fem-1 homolog B

1

7

Small-scale

0.479

High

1460018

ATS6
A disintegrin and metalloproteinase with thrombospondin motifs 6

1

3

High-throughput

0.479

High

1460020

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

1459083

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.460

High

643581

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

Small-scale

0.458

High

1452810

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

Small-scale

0.458

High

1460022

S4R435
Small ribosomal subunit protein eS10

1

4

High-throughput

0.457

High

618166

K2C4
Keratin, type II cytoskeletal 4

1

4

High-throughput

0.445

High

1413710

TMM43
Transmembrane protein 43

2

0

High-throughput

0.316

High

518444

PYY
Peptide YY

1

0

High-throughput

0.279

Low

1460021

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025