Protein: SEPR
Prolyl endopeptidase FAP (EC 3.4.21.26) (170 kDa melanoma membrane-bound gelatinase) (Dipeptidyl peptidase FAP) (EC 3.4.14.5) (Fibroblast activation protein alpha) (FAPalpha) (Gelatine degradation protease FAP) (EC 3.4.21.-) (Integral membrane serine protease) (Post-proline cleaving enzyme) (Serine integral membrane protease) (SIMP) (Surface-expressed protease) (Seprase) [Cleaved into: Antiplasmin-cleaving enzyme FAP, soluble form (APCE) (EC 3.4.14.5) (EC 3.4.21.-) (EC 3.4.21.26)]

Gene: SEPR, FAP
Organism: Homo sapiens
Interactions: 36
UniProt ID: Q12884

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0002020 - protease binding
GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005178 - integrin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

366676

ADA
Adenosine deaminase

1

1

Small-scale

0.618

High

692945

DPP4
Dipeptidyl peptidase 4

1

10

Small-scale

0.618

High

1088809

SCN3B
Sodium channel regulatory subunit beta-3

1

0

High-throughput

0.546

High

1042615

UPAR
Urokinase plasminogen activator surface receptor

1

0

Small-scale

0.480

High

321228

ERLN2
Erlin-2

1

7

Small-scale

0.479

High

690239

STOM
Stomatin

1

5

Small-scale

0.479

High

766499

PHB1
Prohibitin 1

1

5

Small-scale

0.479

High

1023224

RBM3
RNA-binding protein 3

1

1

Small-scale

0.479

High

1041029

CAV1
Caveolin-1

1

1

Small-scale

0.479

High

1088805

PHB2
Prohibitin-2

1

5

Small-scale

0.479

High

218126

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

406970

THY1
Thy-1 membrane glycoprotein

1

0

Small-scale

0.458

High

1088803

CBCO1
Ciliary-associated calcium-binding coiled-coil protein 1

1

0

High-throughput

0.458

High

1088807

RBM4
RNA-binding protein 4

1

0

Small-scale

0.458

High

1088808

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

377283

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

1

1

Small-scale

0.445

High

377309

VIP
VIP peptides [Cleaved into: Intestinal peptide PHV-42

1

5

Small-scale

0.445

High

377326

SLIB
Somatoliberin

1

1

Small-scale

0.445

High

377342

NPY
Pro-neuropeptide Y [Cleaved into: Neuropeptide Y

1

3

Small-scale

0.445

High

485936

GIP
Gastric inhibitory polypeptide

1

1

Small-scale

0.445

High

518438

PYY
Peptide YY

1

3

Small-scale

0.445

High

598732

ANFB
Natriuretic peptides B

1

1

Small-scale

0.445

High

609664

LEG3
Galectin-3

1

2

High-throughput

0.445

High

615178

PACA
Pituitary adenylate cyclase-activating polypeptide

1

3

Small-scale

0.445

High

631803

TKN1
Protachykinin-1

1

1

Small-scale

0.445

High

937466

CDN2D
Cyclin-dependent kinase 4 inhibitor D

1

2

High-throughput

0.445

High

1010027

DLK1
Protein delta homolog 1

1

2

High-throughput

0.445

High

388523

CRP

1

0

High-throughput

0.426

High

567760

ONCM
Oncostatin-M

1

0

High-throughput

0.426

High

1088804

DDX1
ATP-dependent RNA helicase DDX1

1

0

High-throughput

0.426

High

1088811

FBX2
F-box only protein 2

1

0

High-throughput

0.426

High

170743

CLGN
Calmegin

1

4

High-throughput

0.407

High

371892

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

1088806

TM109
Voltage-gated monoatomic cation channel TMEM109

1

0

Small-scale

0.249

Low

1088810

MSRB1
Methionine-R-sulfoxide reductase B1

1

0

Small-scale

0.249

Low

1088802

RWDD4
RWD domain-containing protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025