Protein: MKRN1
E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1)

Gene: MKRN1
Organism: Homo sapiens
Interactions: 166
UniProt ID: Q9UHC7

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0003723 - RNA binding
GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1355324

MKRN1
E3 ubiquitin-protein ligase makorin-1

2

7

Small-scale

0.799

High

849477

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

14

High-throughput

0.783

High

872225

RD23A
UV excision repair protein RAD23 homolog A

2

2

High-throughput

0.783

High

872316

RD23B
UV excision repair protein RAD23 homolog B

2

2

High-throughput

0.783

High

1355338

UB2D4
Ubiquitin-conjugating enzyme E2 D4

2

14

High-throughput

0.783

High

1327004

MKRN2
E3 ubiquitin-protein ligase makorin-2

2

8

High-throughput

0.754

High

181266

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.691

High

945383

PRR3
Proline-rich protein 3

1

2

High-throughput

0.691

High

516728

PABP1
Polyadenylate-binding protein 1

3

9

Small-scale

0.670

High

895942

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

14

High-throughput

0.656

High

1284895

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

15

High-throughput

0.656

High

1031488

PABP4
Polyadenylate-binding protein 4

3

9

Small-scale

0.656

High

387676

P53
Cellular tumor antigen p53

2

1

Small-scale

0.641

High

442571

RU17
U1 small nuclear ribonucleoprotein 70 kDa

2

20

High-throughput

0.628

High

1132325

CELF3
CUGBP Elav-like family member 3

2

17

High-throughput

0.628

High

1349298

NOP53
Ribosome biogenesis protein NOP53

2

2

High-throughput

0.628

High

476523

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

Small-scale

0.618

High

1023579

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

8

High-throughput

0.618

High

1319108

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

15

High-throughput

0.618

High

128331

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

2

15

Small-scale

0.611

High

931467

YBOX1
Y-box-binding protein 1

2

9

Small-scale

0.611

High

1040438

TRA2A
Transformer-2 protein homolog alpha

2

12

High-throughput

0.611

High

1355339

LC7L2
Putative RNA-binding protein Luc7-like 2

2

2

High-throughput

0.611

High

1343073

LUC7L
Putative RNA-binding protein Luc7-like 1

3

2

High-throughput

0.609

High

883398

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

2

High-throughput

0.606

High

963283

U2AF1
Splicing factor U2AF 35 kDa subunit

1

0

Small-scale

0.586

High

758355

CDN1A
Cyclin-dependent kinase inhibitor 1

2

0

Small-scale

0.585

High

1065904

RRS1
Ribosome biogenesis regulatory protein homolog

2

0

High-throughput

0.585

High

1251064

SNIP1
Smad nuclear-interacting protein 1

2

0

High-throughput

0.585

High

1077530

ELAV1
ELAV-like protein 1

2

11

Small-scale

0.584

High

1162706

LARP1
La-related protein 1

2

8

Small-scale

0.584

High

1349160

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

2

9

Small-scale

0.584

High

133058

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

782305

NAA10
N-alpha-acetyltransferase 10

2

0

High-throughput

0.580

High

1046987

BYST
Bystin

2

0

High-throughput

0.580

High

1138866

OTU1
Ubiquitin thioesterase OTU1

2

0

High-throughput

0.580

High

1354561

DAXX
Death domain-associated protein 6

2

0

High-throughput

0.580

High

370648

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

626279

APC
Adenomatous polyposis coli protein

1

4

Small-scale

0.561

High

1026660

FADD
FAS-associated death domain protein

1

1

Small-scale

0.561

High

154062

TERT
Telomerase reverse transcriptase

2

0

Small-scale

0.559

High

760378

RL3
Large ribosomal subunit protein uL3

2

0

Small-scale

0.559

High

1354082

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

4

High-throughput

0.541

High

807582

RS10
Small ribosomal subunit protein eS10

1

1

Small-scale

0.536

High

241381

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

11

High-throughput

0.536

High

281458

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.536

High

432978

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

15

High-throughput

0.536

High

952171

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.536

High

1073888

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

19

High-throughput

0.536

High

1092931

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

4

High-throughput

0.536

High

1168973

LN28B
Protein lin-28 homolog B

1

9

High-throughput

0.536

High

1222988

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

4

High-throughput

0.536

High

1288644

PABP5
Polyadenylate-binding protein 5

1

9

High-throughput

0.536

High

1327222

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

3

High-throughput

0.536

High

1347164

RFOX1
RNA binding protein fox-1 homolog 1

1

15

High-throughput

0.536

High

1348976

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

1

High-throughput

0.536

High

1355325

PURG
Purine-rich element-binding protein gamma

1

2

High-throughput

0.536

High

1355327

ZN346
Zinc finger protein 346

1

2

High-throughput

0.536

High

1355336

YBOX2
Y-box-binding protein 2

1

9

High-throughput

0.536

High

835127

TSC2
Tuberin

1

0

High-throughput

0.518

High

147826

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.513

High

549016

NQO1
NAD(P)H dehydrogenase [quinone] 1

1

0

High-throughput

0.513

High

1224722

SELH
Selenoprotein H

1

0

High-throughput

0.513

High

309932

KCNH1
Potassium voltage-gated channel subfamily H member 1

1

2

Small-scale

0.512

High

1313941

DUS23
Dual specificity protein phosphatase 23

1

2

High-throughput

0.508

High

1326198

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

1

High-throughput

0.508

High

1355328

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

2

High-throughput

0.489

High

1284992

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.486

High

1336453

KC1G1
Casein kinase I isoform gamma-1

1

0

High-throughput

0.486

High

236119

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

14

Small-scale

0.479

High

431062

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

2

High-throughput

0.479

High

509154

TOP2A
DNA topoisomerase 2-alpha

1

2

High-throughput

0.479

High

541431

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

545917

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

4

Small-scale

0.479

High

551007

RS2
Small ribosomal subunit protein uS5

1

1

Small-scale

0.479

High

563213

YBOX3
Y-box-binding protein 3

1

9

Small-scale

0.479

High

577701

SON
Protein SON

1

2

High-throughput

0.479

High

578184

RL17
Large ribosomal subunit protein uL22

1

1

Small-scale

0.479

High

585579

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

2

Small-scale

0.479

High

613610

SFPQ
Splicing factor, proline- and glutamine-rich

1

13

High-throughput

0.479

High

641964

U2AF2
Splicing factor U2AF 65 kDa subunit

1

15

Small-scale

0.479

High

783132

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

790612

RL35
Large ribosomal subunit protein uL29

1

1

Small-scale

0.479

High

801449

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.479

High

807043

RS9
Small ribosomal subunit protein uS4

1

1

Small-scale

0.479

High

814554

SYQ
Glutamine--tRNA ligase

1

2

High-throughput

0.479

High

853113

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

8

Small-scale

0.479

High

898783

RL26
Large ribosomal subunit protein uL24

1

2

Small-scale

0.479

High

907584

RS8
Small ribosomal subunit protein eS8

1

1

Small-scale

0.479

High

911550

RS11
Small ribosomal subunit protein uS17

1

1

Small-scale

0.479

High

915112

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

Small-scale

0.479

High

916428

RL23A
Large ribosomal subunit protein uL23

1

2

Small-scale

0.479

High

922450

RL31
Large ribosomal subunit protein eL31

1

1

Small-scale

0.479

High

960581

PURA
Transcriptional activator protein Pur-alpha

1

2

Small-scale

0.479

High

962437

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

4

Small-scale

0.479

High

963580

TIAR
Nucleolysin TIAR

1

8

Small-scale

0.479

High

991908

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

4

High-throughput

0.479

High

1019988

ILF3
Interleukin enhancer-binding factor 3

1

4

Small-scale

0.479

High

1048265

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

17

Small-scale

0.479

High

1052792

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

8

Small-scale

0.479

High

1056770

PUM1
Pumilio homolog 1

1

3

Small-scale

0.479

High

1057417

SMC1A
Structural maintenance of chromosomes protein 1A

1

2

High-throughput

0.479

High

1057701

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

1

High-throughput

0.479

High

1065592

SYK
Lysine--tRNA ligase

1

1

High-throughput

0.479

High

1073286

PUM3
Pumilio homolog 3

1

3

High-throughput

0.479

High

1152551

Q6ICH2
Apolipoprotein B mRNA editing enzyme catalytic subunit 3D

1

6

High-throughput

0.479

High

1184080

DHX30
ATP-dependent RNA helicase DHX30

1

2

High-throughput

0.479

High

1192253

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

1255235

BRX1
Ribosome biogenesis protein BRX1 homolog

1

2

High-throughput

0.479

High

1262735

ATX2L
Ataxin-2-like protein

1

5

Small-scale

0.479

High

1268190

LAR4B
La-related protein 4B

1

8

Small-scale

0.479

High

1272388

RENT1
Regulator of nonsense transcripts 1

1

5

Small-scale

0.479

High

1302240

STRBP
Spermatid perinuclear RNA-binding protein

1

6

Small-scale

0.479

High

1303828

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.479

High

1305715

ATX2
Ataxin-2

1

3

Small-scale

0.479

High

1316477

RM13
Large ribosomal subunit protein uL13m

1

1

High-throughput

0.479

High

1326362

DDX24
ATP-dependent RNA helicase DDX24

1

2

High-throughput

0.479

High

1335994

MOV10
Helicase MOV-10

1

5

Small-scale

0.479

High

1346008

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

7

Small-scale

0.479

High

1350378

SYLC
Leucine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

1355326

AGO2
Protein argonaute-2

1

3

Small-scale

0.479

High

1355329

FZR1
Fizzy-related protein homolog

1

5

High-throughput

0.479

High

1355330

PRP19
Pre-mRNA-processing factor 19

1

4

High-throughput

0.479

High

1355331

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

3

Small-scale

0.479

High

1355334

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.479

High

1355337

TR150
Thyroid hormone receptor-associated protein 3

1

8

High-throughput

0.479

High

1355341

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

11

Small-scale

0.479

High

132237

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

170733

AXIN1
Axin-1

1

0

Small-scale

0.458

High

215705

AKAP8
A-kinase anchor protein 8

1

0

Small-scale

0.458

High

268891

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.458

High

649809

RL10
Large ribosomal subunit protein uL16

1

0

Small-scale

0.458

High

806212

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

867783

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

874194

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.458

High

875404

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

911287

RS13
Small ribosomal subunit protein uS15

1

0

Small-scale

0.458

High

920714

RS26
Small ribosomal subunit protein eS26

1

0

Small-scale

0.458

High

1019457

AIMP1
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

1

0

High-throughput

0.458

High

1047834

CKAP5
Cytoskeleton-associated protein 5

1

0

High-throughput

0.458

High

1120483

NCBP3
Nuclear cap-binding protein subunit 3

1

0

Small-scale

0.458

High

1159324

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

1189965

NUFP2
FMR1-interacting protein NUFIP2

1

0

Small-scale

0.458

High

1238724

KRI1
Protein KRI1 homolog

1

0

High-throughput

0.458

High

1327375

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

1332931

RPF2
Ribosome production factor 2 homolog

1

0

High-throughput

0.458

High

1355335

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.458

High

1355340

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.458

High

70218

B2CML4
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3DE

1

6

High-throughput

0.445

High

101256

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

278560

SPF27
Pre-mRNA-splicing factor SPF27

1

1

High-throughput

0.437

High

348162

MYC
Myc proto-oncogene protein

1

9

High-throughput

0.437

High

379991

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.437

High

1057014

MDC1
Mediator of DNA damage checkpoint protein 1

1

5

High-throughput

0.437

High

1262833

PHIP
PH-interacting protein

1

3

High-throughput

0.437

High

1269857

ESR2
Estrogen receptor beta

1

6

High-throughput

0.437

High

1355333

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

1

Small-scale

0.437

High

1107954

F161A
Protein FAM161A

2

0

High-throughput

0.316

High

1232318

MTURN
Maturin

2

0

High-throughput

0.316

High

1288104

OTUB2
Ubiquitin thioesterase OTUB2

2

0

High-throughput

0.316

High

1318448

S13A1
Solute carrier family 13 member 1

1

0

Small-scale

0.251

Low

62994

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.249

Low

229517

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

0

High-throughput

0.249

Low

1355332

TUTLB
Protein turtle homolog B

1

0

Small-scale

0.249

Low

1303360

SCN2A
Sodium channel protein type 2 subunit alpha

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024