Protein: GEN
Flap endonuclease GEN homolog 1 (EC 3.1.-.-)

Gene: GEN, GEN1
Organism: Homo sapiens
Interactions: 29
UniProt ID: Q17RS7

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0000400 - four-way junction DNA binding
GO:0000724 - double-strand break repair via homologous recombination
GO:0005654 - nucleoplasm
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1165430

CP135
Centrosomal protein of 135 kDa

2

0

High-throughput

0.559

High

375562

RASK
GTPase KRas

2

1

High-throughput

0.533

High

943581

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

1

High-throughput

0.494

High

775122

FUS
RNA-binding protein FUS

1

2

High-throughput

0.479

High

1107771

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1165436

ANLN
Anillin

1

1

High-throughput

0.479

High

1165437

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1165438

ANC2
Anaphase-promoting complex subunit 2

1

1

High-throughput

0.479

High

1035661

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

1113227

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1123644

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

1165429

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.458

High

1165432

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.458

High

241836

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.437

High

345890

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.437

High

373957

RASN
GTPase NRas

1

1

High-throughput

0.437

High

966373

1433G
14-3-3 protein gamma

1

10

High-throughput

0.437

High

1049335

1433F
14-3-3 protein eta

1

10

High-throughput

0.437

High

1140346

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

1156502

CCDC6
Coiled-coil domain-containing protein 6

1

1

High-throughput

0.437

High

1165431

SYNE3
Nesprin-3

1

1

High-throughput

0.437

High

1165434

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

1165435

TRI36
E3 ubiquitin-protein ligase TRIM36

1

2

High-throughput

0.437

High

251903

PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [Includes: Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

1

0

High-throughput

0.279

Low

630287

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

0

High-throughput

0.279

Low

953474

RAC3
Ras-related C3 botulinum toxin substrate 3

1

0

High-throughput

0.249

Low

1165433

RMD3
Regulator of microtubule dynamics protein 3

1

0

High-throughput

0.249

Low

1165439

MARE3
Microtubule-associated protein RP/EB family member 3

1

0

High-throughput

0.249

Low

1165440

USH1C
Harmonin

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025