Protein: ANC2
Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)

Gene: ANC2, ANAPC2
Organism: Homo sapiens
Interactions: 236
UniProt ID: Q9UJX6

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005829 - cytosol
GO:0007091 - metaphase/anaphase transition of mitotic cell cycle
GO:0007346 - regulation of mitotic cell cycle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1460765

APC4
Anaphase-promoting complex subunit 4

10

3

Small-scale

0.973

High

1093082

CDC16
Cell division cycle protein 16 homolog

8

20

Small-scale

0.968

High

1452595

APC11
Anaphase-promoting complex subunit 11

7

20

Small-scale

0.956

High

251821

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

5

16

High-throughput

0.932

High

1460774

FBX5
F-box only protein 5

5

4

Small-scale

0.928

High

1162719

UBE2S
Ubiquitin-conjugating enzyme E2 S

4

18

Small-scale

0.901

High

144201

UBE2C
Ubiquitin-conjugating enzyme E2 C

4

20

Small-scale

0.896

High

1460777

APC10
Anaphase-promoting complex subunit 10

2

9

Small-scale

0.789

High

718655

CDC27
Cell division cycle protein 27 homolog

17

18

Small-scale

0.761

High

1086934

CDC20
Cell division cycle protein 20 homolog

14

20

Small-scale

0.758

High

1460776

FZR1
Fizzy-related protein homolog

10

20

Small-scale

0.756

High

1460755

APC5
Anaphase-promoting complex subunit 5

7

4

Small-scale

0.741

High

1460723

CDC23
Cell division cycle protein 23 homolog

6

20

Small-scale

0.729

High

1430912

APC1
Anaphase-promoting complex subunit 1

6

4

Small-scale

0.722

High

1340922

CDC26
Anaphase-promoting complex subunit CDC26

6

0

Small-scale

0.696

High

992377

SKP1
S-phase kinase-associated protein 1

1

20

High-throughput

0.691

High

908872

NEK2
Serine/threonine-protein kinase Nek2

4

10

Small-scale

0.683

High

965315

WDR5
WD repeat-containing protein 5

3

20

Small-scale

0.672

High

292879

GRAP2
GRB2-related adapter protein 2

3

7

High-throughput

0.667

High

1387381

APC16
Anaphase-promoting complex subunit 16

4

0

High-throughput

0.658

High

1460747

APC7
Anaphase-promoting complex subunit 7

3

20

Small-scale

0.656

High

508802

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

982357

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

18

Small-scale

0.647

High

1412130

APC13
Anaphase-promoting complex subunit 13

3

0

High-throughput

0.646

High

948607

APC15
Anaphase-promoting complex subunit 15

3

0

Small-scale

0.638

High

224178

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

15

High-throughput

0.618

High

731687

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.618

High

1060587

KLC1
Kinesin light chain 1

1

10

High-throughput

0.618

High

1114610

CUL3
Cullin-3

1

16

High-throughput

0.618

High

1115128

CUL4A
Cullin-4A

1

16

High-throughput

0.618

High

1148080

SF3B3
Splicing factor 3B subunit 3

1

18

High-throughput

0.618

High

1310811

CUL9
Cullin-9

1

14

Small-scale

0.618

High

1371213

GLMN
Glomulin

1

5

High-throughput

0.618

High

1429719

KLC2
Kinesin light chain 2

1

14

High-throughput

0.618

High

1447695

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

17

High-throughput

0.618

High

1460773

FBX2
F-box only protein 2

1

8

Small-scale

0.618

High

1099814

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

1

Small-scale

0.611

High

1116112

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

15

High-throughput

0.611

High

351295

TTLL1
Polyglutamylase complex subunit TTLL1

3

1

High-throughput

0.609

High

1435268

MAGIX
PDZ domain-containing protein MAGIX

3

9

High-throughput

0.609

High

353829

PTTG1
Securin

2

1

Small-scale

0.602

High

442829

RB
Retinoblastoma-associated protein

2

4

Small-scale

0.584

High

920348

PLK1
Serine/threonine-protein kinase PLK1

2

8

High-throughput

0.584

High

1214500

Q5T8C6
Cell division cycle 16

1

20

High-throughput

0.575

High

1437013

ZN408
Zinc finger protein 408

2

20

High-throughput

0.574

High

893755

MEOX1
Homeobox protein MOX-1

2

6

High-throughput

0.553

High

1194737

FBX43
F-box only protein 43

1

4

Small-scale

0.553

High

1311421

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

8

High-throughput

0.553

High

1449435

KLC4
Kinesin light chain 4

1

12

High-throughput

0.553

High

1460781

ANR26
Ankyrin repeat domain-containing protein 26

1

16

High-throughput

0.553

High

1460787

NPTN
Neuroplastin

2

9

High-throughput

0.549

High

610501

PRS6A
26S proteasome regulatory subunit 6A

1

16

High-throughput

0.536

High

721177

SORCN
Sorcin

1

8

High-throughput

0.536

High

788810

SRP14
Signal recognition particle 14 kDa protein

1

2

High-throughput

0.536

High

872865

SOX2
Transcription factor SOX-2

1

13

High-throughput

0.536

High

1370448

CSN5
COP9 signalosome complex subunit 5

1

15

High-throughput

0.536

High

1385537

P5CR2
Pyrroline-5-carboxylate reductase 2

1

4

High-throughput

0.536

High

1404488

CDC5L
Cell division cycle 5-like protein

1

4

High-throughput

0.536

High

1407626

TCPH
T-complex protein 1 subunit eta

1

9

High-throughput

0.536

High

1153942

SMAD2
Mothers against decapentaplegic homolog 2

1

7

High-throughput

0.508

High

1369997

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

2

High-throughput

0.508

High

964501

SUMO2
Small ubiquitin-related modifier 2

1

1

Small-scale

0.501

High

734027

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

4

High-throughput

0.489

High

136011

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

5

High-throughput

0.479

High

164126

NDC80
Kinetochore protein NDC80 homolog

1

20

High-throughput

0.479

High

171781

GAK
Cyclin-G-associated kinase

1

11

High-throughput

0.479

High

176279

SYNJ2
Synaptojanin-2

1

3

High-throughput

0.479

High

220812

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

1

High-throughput

0.479

High

244617

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

11

High-throughput

0.479

High

258572

DIAP2
Protein diaphanous homolog 2

1

2

High-throughput

0.479

High

259168

DNJA2
DnaJ homolog subfamily A member 2

1

10

High-throughput

0.479

High

272536

OBSL1
Obscurin-like protein 1

1

12

High-throughput

0.479

High

316133

RECQ4
ATP-dependent DNA helicase Q4

1

20

High-throughput

0.479

High

317262

AL1A2
Retinal dehydrogenase 2

1

4

High-throughput

0.479

High

324233

CE152
Centrosomal protein of 152 kDa

1

8

High-throughput

0.479

High

340259

PCNT
Pericentrin

1

18

High-throughput

0.479

High

341700

EYA4
Protein phosphatase EYA4

1

12

High-throughput

0.479

High

358823

LDHA
L-lactate dehydrogenase A chain

1

4

High-throughput

0.479

High

414804

P53
Cellular tumor antigen p53

1

7

High-throughput

0.479

High

426352

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

2

High-throughput

0.479

High

451089

LDHB
L-lactate dehydrogenase B chain

1

4

High-throughput

0.479

High

462021

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.479

High

467974

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

2

High-throughput

0.479

High

468893

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.479

High

488566

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

3

High-throughput

0.479

High

553293

KCRB
Creatine kinase B-type

1

3

High-throughput

0.479

High

668747

APC
Adenomatous polyposis coli protein

1

15

High-throughput

0.479

High

723138

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

High-throughput

0.479

High

750493

CSTF2
Cleavage stimulation factor subunit 2

1

20

High-throughput

0.479

High

778804

PRS7
26S proteasome regulatory subunit 7

1

9

High-throughput

0.479

High

814883

CUX1
Homeobox protein cut-like 1

1

16

High-throughput

0.479

High

832145

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

15

High-throughput

0.479

High

838469

GRIA1
Glutamate receptor 1

1

1

Small-scale

0.479

High

851438

PRS6B
26S proteasome regulatory subunit 6B

1

7

High-throughput

0.479

High

881816

DHYS
Deoxyhypusine synthase

1

1

High-throughput

0.479

High

896924

DYN2
Dynamin-2

1

2

High-throughput

0.479

High

906214

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

6

High-throughput

0.479

High

906465

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.479

High

913609

KIF11
Kinesin-like protein KIF11

1

9

High-throughput

0.479

High

922076

COPA
Coatomer subunit alpha

1

14

High-throughput

0.479

High

923647

TTC3
E3 ubiquitin-protein ligase TTC3

1

13

High-throughput

0.479

High

929846

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

932153

EPHA4
Ephrin type-A receptor 4

1

4

Small-scale

0.479

High

945326

NU107
Nuclear pore complex protein Nup107

1

1

High-throughput

0.479

High

959288

ABCE1
ATP-binding cassette sub-family E member 1

1

5

High-throughput

0.479

High

980512

H4
Histone H4

1

6

High-throughput

0.479

High

1007334

TCPB
T-complex protein 1 subunit beta

1

9

High-throughput

0.479

High

1008394

PRKDC
DNA-dependent protein kinase catalytic subunit

1

7

Small-scale

0.479

High

1028442

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

1038722

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

8

High-throughput

0.479

High

1063202

GOGA3
Golgin subfamily A member 3

1

10

High-throughput

0.479

High

1067815

EP300
Histone acetyltransferase p300

1

18

Small-scale

0.479

High

1087039

KIF5A
Kinesin heavy chain isoform 5A

1

13

High-throughput

0.479

High

1089057

TP53B
TP53-binding protein 1

1

10

High-throughput

0.479

High

1093331

FLII
Protein flightless-1 homolog

1

5

High-throughput

0.479

High

1103434

CTBP1
C-terminal-binding protein 1

1

8

High-throughput

0.479

High

1125726

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

7

High-throughput

0.479

High

1129781

MDC1
Mediator of DNA damage checkpoint protein 1

1

14

High-throughput

0.479

High

1130214

SMC1A
Structural maintenance of chromosomes protein 1A

1

8

High-throughput

0.479

High

1140161

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

1

High-throughput

0.479

High

1141007

KIF14
Kinesin-like protein KIF14

1

13

High-throughput

0.479

High

1157571

PKN2
Serine/threonine-protein kinase N2

1

5

High-throughput

0.479

High

1165438

GEN
Flap endonuclease GEN homolog 1

1

1

High-throughput

0.479

High

1178648

KIF7
Kinesin-like protein KIF7

1

8

High-throughput

0.479

High

1217517

CE350
Centrosome-associated protein 350

1

9

High-throughput

0.479

High

1241604

CEP85
Centrosomal protein of 85 kDa

1

20

High-throughput

0.479

High

1287148

PATL1
Protein PAT1 homolog 1

1

4

High-throughput

0.479

High

1289208

N4BP2
NEDD4-binding protein 2

1

1

High-throughput

0.479

High

1309502

CEP97
Centrosomal protein of 97 kDa

1

7

High-throughput

0.479

High

1310180

GCC2
GRIP and coiled-coil domain-containing protein 2

1

18

High-throughput

0.479

High

1312389

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

7

High-throughput

0.479

High

1322810

CNTRB
Centrobin

1

13

High-throughput

0.479

High

1336880

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

16

High-throughput

0.479

High

1350200

ALMS1
Centrosome-associated protein ALMS1

1

15

High-throughput

0.479

High

1351424

CABL1
CDK5 and ABL1 enzyme substrate 1

1

2

High-throughput

0.479

High

1364006

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

4

High-throughput

0.479

High

1365556

JADE3
Protein Jade-3

1

5

High-throughput

0.479

High

1367544

ESR2
Estrogen receptor beta

1

12

High-throughput

0.479

High

1368521

CBP
CREB-binding protein

1

15

Small-scale

0.479

High

1380414

RNF34
E3 ubiquitin-protein ligase RNF34

1

7

Small-scale

0.479

High

1382601

EXOC4
Exocyst complex component 4

1

1

High-throughput

0.479

High

1386797

GCP3
Gamma-tubulin complex component 3

1

5

High-throughput

0.479

High

1388765

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

7

Small-scale

0.479

High

1396907

KI16B
Kinesin-like protein KIF16B

1

10

High-throughput

0.479

High

1401187

SPAG5
Sperm-associated antigen 5

1

20

High-throughput

0.479

High

1402923

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.479

High

1405290

NUP88
Nuclear pore complex protein Nup88

1

2

High-throughput

0.479

High

1405816

TTC1
Tetratricopeptide repeat protein 1

1

6

High-throughput

0.479

High

1405905

DNJC7
DnaJ homolog subfamily C member 7

1

10

High-throughput

0.479

High

1406578

METH
Methionine synthase

1

3

High-throughput

0.479

High

1411363

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.479

High

1412555

GCP2
Gamma-tubulin complex component 2

1

5

High-throughput

0.479

High

1415610

AFG2B
ATPase family gene 2 protein homolog B

1

12

High-throughput

0.479

High

1416736

OSB11
Oxysterol-binding protein-related protein 11

1

4

High-throughput

0.479

High

1430192

CSTFT
Cleavage stimulation factor subunit 2 tau variant

1

20

High-throughput

0.479

High

1432535

P63
Tumor protein 63

1

7

Small-scale

0.479

High

1433860

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

14

High-throughput

0.479

High

1434898

HAUS4
HAUS augmin-like complex subunit 4

1

1

High-throughput

0.479

High

1435194

RPAP3
RNA polymerase II-associated protein 3

1

14

High-throughput

0.479

High

1435587

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

10

High-throughput

0.479

High

1437972

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.479

High

1438734

CPAP
Centrosomal P4.1-associated protein

1

12

High-throughput

0.479

High

1448707

LATS2
Serine/threonine-protein kinase LATS2

1

13

Small-scale

0.479

High

1449218

KIF15
Kinesin-like protein KIF15

1

9

High-throughput

0.479

High

1449463

DIAP3
Protein diaphanous homolog 3

1

2

High-throughput

0.479

High

1451817

LYAR
Cell growth-regulating nucleolar protein

1

2

High-throughput

0.479

High

1453034

TLS1
Splicing factor C9orf78

1

4

High-throughput

0.479

High

1460414

HERC5
E3 ISG15--protein ligase HERC5

1

10

Small-scale

0.479

High

1460778

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

High-throughput

0.479

High

1460779

CP131
Centrosomal protein of 131 kDa

1

9

High-throughput

0.479

High

1460780

PHF8
Histone lysine demethylase PHF8

1

6

Small-scale

0.479

High

1460782

DRG1
Developmentally-regulated GTP-binding protein 1

1

4

High-throughput

0.479

High

1460783

NINL
Ninein-like protein

1

13

Small-scale

0.479

High

1460785

SGT1
Protein SGT1 homolog

1

5

High-throughput

0.479

High

71776

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

0

High-throughput

0.458

High

213270

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.458

High

250167

ADCY9
Adenylate cyclase type 9

1

0

High-throughput

0.458

High

290198

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

322476

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.458

High

904408

BRCA2
Breast cancer type 2 susceptibility protein

1

0

High-throughput

0.458

High

925692

IST1
IST1 homolog

1

0

Small-scale

0.458

High

1169046

CSPP1
Centrosome and spindle pole-associated protein 1

1

0

High-throughput

0.458

High

1233222

THOC7
THO complex subunit 7

1

0

High-throughput

0.458

High

1312173

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.458

High

1385715

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.458

High

1396233

CNDP2
Cytosolic non-specific dipeptidase

1

0

High-throughput

0.458

High

1436895

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.458

High

171615

S27A2
Long-chain fatty acid transport protein 2

1

6

High-throughput

0.445

High

1384296

SH3K1
SH3 domain-containing kinase-binding protein 1

1

7

High-throughput

0.445

High

161649

RGPD8
RANBP2-like and GRIP domain-containing protein 8

1

9

High-throughput

0.437

High

191857

MAGB2
Melanoma-associated antigen B2

1

5

High-throughput

0.437

High

444016

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

5

High-throughput

0.437

High

568524

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

755645

TTK
Dual specificity protein kinase TTK

1

9

High-throughput

0.437

High

1004301

F193A
Protein FAM193A

1

2

High-throughput

0.437

High

1081613

DYH14
Dynein axonemal heavy chain 14

1

4

High-throughput

0.437

High

1185237

EDRF1
Erythroid differentiation-related factor 1

1

1

High-throughput

0.437

High

1195710

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

3

High-throughput

0.437

High

1214960

CCD18
Coiled-coil domain-containing protein 18

1

16

High-throughput

0.437

High

1218498

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

2

High-throughput

0.437

High

1256021

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1307213

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

12

High-throughput

0.437

High

1308609

NUDC3
NudC domain-containing protein 3

1

3

High-throughput

0.437

High

1327745

MACOI
Macoilin

1

11

High-throughput

0.437

High

1351400

DLG5
Disks large homolog 5

1

6

High-throughput

0.437

High

1383157

LRC59
Leucine-rich repeat-containing protein 59

1

11

High-throughput

0.437

High

1396983

IFT74
Intraflagellar transport protein 74 homolog

1

18

High-throughput

0.437

High

1397847

CC138
Coiled-coil domain-containing protein 138

1

1

High-throughput

0.437

High

1406300

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

9

High-throughput

0.437

High

1416040

SYTM
Threonine--tRNA ligase, mitochondrial

1

7

High-throughput

0.437

High

1434186

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.437

High

1439179

Q9HCK3
KIAA1569 protein

1

1

High-throughput

0.437

High

1445963

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

6

High-throughput

0.437

High

1447564

MYO5C
Unconventional myosin-Vc

1

4

High-throughput

0.437

High

1451748

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.437

High

1451973

NSMA3
Sphingomyelin phosphodiesterase 4

1

1

High-throughput

0.437

High

1454564

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

7

High-throughput

0.437

High

1460775

ODF2L
Protein BCAP

1

14

High-throughput

0.437

High

1460786

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

3

High-throughput

0.437

High

49036

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

166448

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.407

High

458647

PGS2
Decorin

1

4

High-throughput

0.407

High

1366299

LPAR1
Lysophosphatidic acid receptor 1

1

3

High-throughput

0.407

High

1460784

S27A6
Long-chain fatty acid transport protein 6

1

6

High-throughput

0.407

High

1244450

CP087
UPF0547 protein C16orf87

3

0

High-throughput

0.345

High

66676

CC85C
Coiled-coil domain-containing protein 85C

1

0

High-throughput

0.249

Low

1249315

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1258208

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.249

Low

1330000

TEX9
Testis-expressed protein 9

1

0

High-throughput

0.249

Low

1332530

POC5
Centrosomal protein POC5

1

0

High-throughput

0.249

Low

1361178

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.249

Low

1405224

MPP9
M-phase phosphoprotein 9

1

0

High-throughput

0.249

Low

1415760

TALD3
Protein TALPID3

1

0

High-throughput

0.249

Low

1417938

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.249

Low

1439067

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low

1449123

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025