Protein: TKN1
Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]

Gene: TKN1, TAC1
Organism: Homo sapiens
Interactions: 16
UniProt ID: P20366

Gene Ontology (top 5):
GO:0002675 - positive regulation of acute inflammatory response
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006954 - inflammatory response
GO:0007204 - positive regulation of cytosolic calcium ion concentration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

631798

NK2R
Substance-K receptor

3

2

Small-scale

0.840

High

631799

NK1R
Substance-P receptor

3

2

Small-scale

0.840

High

631801

NK3R
Neuromedin-K receptor

1

2

Small-scale

0.647

High

631805

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

631807

PLEC
Plectin

1

0

High-throughput

0.493

High

557853

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.486

High

631800

DPP4
Dipeptidyl peptidase 4

1

1

Small-scale

0.445

High

631803

SEPR
Prolyl endopeptidase FAP

1

1

Small-scale

0.445

High

631809

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.438

High

254804

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

631806

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

631802

BAG6
Large proline-rich protein BAG6

2

0

High-throughput

0.319

High

451479

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.265

Low

631804

SNX1
Sorting nexin-1

1

0

Small-scale

0.249

Low

631808

GASP1
G-protein coupled receptor-associated sorting protein 1

1

0

Small-scale

0.249

Low

631810

ARH40
Rho guanine nucleotide exchange factor 40

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025