Protein: NK1R
Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)

Gene: NK1R, TACR1
Organism: Homo sapiens
Interactions: 70
UniProt ID: P25103

Gene Ontology (top 5):
GO:0002118 - aggressive behavior
GO:0002687 - positive regulation of leukocyte migration
GO:0003051 - angiotensin-mediated drinking behavior
GO:0004995 - tachykinin receptor activity
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

631799

TKN1
Protachykinin-1

3

2

Small-scale

0.840

High

669223

MTR1L
Melatonin-related receptor

1

19

High-throughput

0.691

High

669218

GRK5
G protein-coupled receptor kinase 5

1

10

Small-scale

0.647

High

125878

ARVC
Splicing regulator ARVCF

2

8

High-throughput

0.628

High

252659

TSN3
Tetraspanin-3

2

10

High-throughput

0.628

High

349376

TSN15
Tetraspanin-15

2

10

High-throughput

0.628

High

360252

COX1
Cytochrome c oxidase subunit 1

2

3

High-throughput

0.628

High

669220

AT12A
Potassium-transporting ATPase alpha chain 2

2

15

High-throughput

0.628

High

669221

CAV1
Caveolin-1

2

4

High-throughput

0.628

High

669222

STX4
Syntaxin-4

2

1

High-throughput

0.628

High

669224

SLMAP
Sarcolemmal membrane-associated protein

2

1

High-throughput

0.628

High

669226

LMBD2
G-protein coupled receptor-associated protein LMBRD2

2

5

High-throughput

0.628

High

669227

MFSD5
Molybdate-anion transporter

2

1

High-throughput

0.628

High

669238

PAQR1
Adiponectin receptor protein 1

2

2

High-throughput

0.628

High

669241

KIRR1
Kin of IRRE-like protein 1

2

3

High-throughput

0.628

High

669242

PKP4
Plakophilin-4

2

9

High-throughput

0.628

High

669245

PKP2
Plakophilin-2

2

8

High-throughput

0.628

High

669250

YIPF3
Protein YIPF3

2

2

High-throughput

0.628

High

669254

GPC5C
G-protein coupled receptor family C group 5 member C

2

3

High-throughput

0.628

High

665516

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

3

2

High-throughput

0.604

High

297150

PRAF3
PRA1 family protein 3

2

0

High-throughput

0.602

High

669248

TM147
BOS complex subunit TMEM147

2

0

High-throughput

0.580

High

223602

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

2

1

High-throughput

0.574

High

226402

SNG2
Synaptogyrin-2

2

2

High-throughput

0.574

High

248560

FADS1
Acyl-CoA

2

4

High-throughput

0.574

High

397726

NU5M
NADH-ubiquinone oxidoreductase chain 5

2

1

High-throughput

0.574

High

515813

RGPD2
RANBP2-like and GRIP domain-containing protein 2

2

1

High-throughput

0.574

High

669225

TM164
Transmembrane protein 164

2

2

High-throughput

0.574

High

669229

HACD2
Very-long-chain

2

2

High-throughput

0.574

High

669233

GOGA5
Golgin subfamily A member 5

2

1

High-throughput

0.574

High

669240

CERS2
Ceramide synthase 2

2

5

High-throughput

0.574

High

669246

PXL2A
Peroxiredoxin-like 2A

2

1

High-throughput

0.574

High

669252

RDH14
Retinol dehydrogenase 14

2

2

High-throughput

0.574

High

669255

CC167
Coiled-coil domain-containing protein 167

2

1

High-throughput

0.553

High

669228

MBOA5
Lysophospholipid acyltransferase 5

2

5

High-throughput

0.549

High

180481

PLS1
Phospholipid scramblase 1

1

1

High-throughput

0.536

High

397578

NU1M
NADH-ubiquinone oxidoreductase chain 1

1

1

High-throughput

0.536

High

397668

NU4M
NADH-ubiquinone oxidoreductase chain 4

1

1

High-throughput

0.536

High

443662

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

7

High-throughput

0.536

High

565560

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

16

High-throughput

0.536

High

669215

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

7

High-throughput

0.536

High

669217

MRP1
Multidrug resistance-associated protein 1

1

1

High-throughput

0.536

High

669219

CAV2
Caveolin-2

1

4

High-throughput

0.536

High

669235

LMBR1
Limb region 1 protein homolog

1

1

High-throughput

0.536

High

669251

T126A
Transmembrane protein 126A

1

3

High-throughput

0.536

High

506554

GPHRB
Golgi pH regulator B

2

6

High-throughput

0.533

High

333557

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

1

0

High-throughput

0.513

High

403129

APOB
Apolipoprotein B-100

1

0

High-throughput

0.513

High

85337

GPHRA
Golgi pH regulator A

2

6

High-throughput

0.504

High

669231

TKN4
Tachykinin-4

1

1

Small-scale

0.501

High

223703

NDUB3
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3

1

2

High-throughput

0.489

High

298666

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

1

High-throughput

0.489

High

397781

ATP8
ATP synthase F(0) complex subunit 8

1

1

High-throughput

0.489

High

669230

ADCK1
AarF domain-containing protein kinase 1

1

7

High-throughput

0.489

High

669232

VKORL
Vitamin K epoxide reductase complex subunit 1-like protein 1

1

1

High-throughput

0.489

High

669237

CDS1
Phosphatidate cytidylyltransferase 1

1

1

High-throughput

0.489

High

669239

S2546
Mitochondrial outer membrane protein SLC25A46

1

3

High-throughput

0.489

High

669243

SGMR1
Sigma non-opioid intracellular receptor 1

1

3

High-throughput

0.489

High

669247

PTSS2
Phosphatidylserine synthase 2

1

2

High-throughput

0.489

High

669253

TM9S3
Transmembrane 9 superfamily member 3

1

6

High-throughput

0.489

High

669244

TM9S2
Transmembrane 9 superfamily member 2

1

6

High-throughput

0.445

High

669234

RDH11
Retinol dehydrogenase 11

1

2

High-throughput

0.407

High

669236

TM9S4
Transmembrane 9 superfamily member 4

1

6

High-throughput

0.407

High

278624

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

0

High-throughput

0.328

High

328356

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

2

0

High-throughput

0.328

High

316480

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

0

High-throughput

0.279

Low

322005

ENDD1
Endonuclease domain-containing 1 protein

1

0

High-throughput

0.279

Low

669216

AOFB
Amine oxidase [flavin-containing] B

1

0

High-throughput

0.279

Low

669249

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.279

Low

669256

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025