Protein: CREL2
Protein disulfide isomerase CRELD2 (EC 5.3.4.1) (Cysteine-rich with EGF-like domain protein 2)

Gene: CREL2, CRELD2
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q6UXH1

Gene Ontology (top 5):
GO:0003756 - protein disulfide isomerase activity
GO:0005509 - calcium ion binding
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

841559

I12R1
Interleukin-12 receptor subunit beta-1

2

8

High-throughput

0.705

High

475484

FA7
Coagulation factor VII

1

12

High-throughput

0.691

High

1249919

ST14
Suppressor of tumorigenicity 14 protein

1

12

High-throughput

0.691

High

335362

CCN6
Cellular communication network factor 6

3

5

High-throughput

0.667

High

144103

WNT7A
Protein Wnt-7a

2

11

High-throughput

0.628

High

397996

FA11
Coagulation factor XI

2

13

High-throughput

0.628

High

942184

WNT4
Protein Wnt-4

2

11

High-throughput

0.611

High

459304

CATL1
Procathepsin L

2

2

High-throughput

0.576

High

183395

MATN3
Matrilin-3

1

20

Small-scale

0.575

High

1249891

LYZL2
Lysozyme-like protein 2

2

5

High-throughput

0.574

High

1249896

ZFP41
Zinc finger protein 41 homolog

2

8

High-throughput

0.558

High

1207818

EPHAA
Ephrin type-A receptor 10

1

7

High-throughput

0.553

High

1249890

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.553

High

570684

EDN3
Endothelin-3

1

2

High-throughput

0.536

High

593405

PGFRA
Platelet-derived growth factor receptor alpha

1

8

High-throughput

0.536

High

647369

IDS
Iduronate 2-sulfatase

1

5

High-throughput

0.536

High

933186

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

2

High-throughput

0.536

High

1245864

BRID5
BRICHOS domain-containing protein 5

1

2

High-throughput

0.536

High

1249894

TAFA2
Chemokine-like protein TAFA-2

1

3

High-throughput

0.536

High

1249898

LCN9
Epididymal-specific lipocalin-9

1

4

High-throughput

0.536

High

1249900

GGH
Gamma-glutamyl hydrolase

1

2

High-throughput

0.536

High

1249902

FUT8
Alpha-(1,6)-fucosyltransferase

1

1

High-throughput

0.536

High

1249904

WN10A
Protein Wnt-10a

1

11

High-throughput

0.536

High

1249908

IL25
Interleukin-25

1

1

High-throughput

0.536

High

842791

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

9

High-throughput

0.523

High

556166

CADH1
Cadherin-1

1

6

High-throughput

0.515

High

697927

CALR
Calreticulin

1

6

High-throughput

0.515

High

843682

HD
Huntingtin

1

2

High-throughput

0.515

High

485941

GIP
Gastric inhibitory polypeptide

1

0

High-throughput

0.513

High

880026

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.513

High

1249905

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.513

High

1249909

TOR3A
Torsin-3A

1

0

High-throughput

0.513

High

885303

HXA1
Homeobox protein Hox-A1

1

8

High-throughput

0.494

High

1249911

LT4R2
Leukotriene B4 receptor 2

1

5

High-throughput

0.494

High

573535

ENPL
Endoplasmin

1

0

High-throughput

0.493

High

1142243

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

High-throughput

0.493

High

154834

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

2

High-throughput

0.489

High

231320

EFNA2
Ephrin-A2

1

5

High-throughput

0.489

High

341324

ECEL1
Endothelin-converting enzyme-like 1

1

4

High-throughput

0.489

High

342596

LY86
Lymphocyte antigen 86

1

3

High-throughput

0.489

High

355367

B3GT4
Beta-1,3-galactosyltransferase 4

1

1

High-throughput

0.489

High

506860

CFC1
Cryptic protein

1

2

High-throughput

0.489

High

567896

PRG2
Bone marrow proteoglycan

1

12

High-throughput

0.489

High

596999

TSHR
Thyrotropin receptor

1

4

High-throughput

0.489

High

756560

GALNS
N-acetylgalactosamine-6-sulfatase

1

5

High-throughput

0.489

High

1160399

TAZ
Tafazzin

1

4

High-throughput

0.489

High

1248549

LYPD4
Ly6/PLAUR domain-containing protein 4

1

1

High-throughput

0.489

High

1248761

LYZL1
Lysozyme-like protein 1

1

5

High-throughput

0.489

High

1249893

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

2

High-throughput

0.489

High

1249899

PATE1
Prostate and testis expressed protein 1

1

2

High-throughput

0.489

High

1249901

ESPB1
Epididymal sperm-binding protein 1

1

5

High-throughput

0.489

High

1249903

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

1

1

High-throughput

0.489

High

1249906

SIRPD
Signal-regulatory protein delta

1

4

High-throughput

0.489

High

1204163

MEST
Mesoderm-specific transcript homolog protein

1

0

High-throughput

0.486

High

218350

TGON2
Trans-Golgi network integral membrane protein 2

1

14

High-throughput

0.479

High

680718

CATS
Cathepsin S

1

2

High-throughput

0.479

High

1113462

CUL3
Cullin-3

1

13

High-throughput

0.479

High

1249912

TMPS4
Transmembrane protease serine 4

1

11

High-throughput

0.479

High

693007

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.470

High

1053247

Q05BL1
TP53BP2 protein

1

4

High-throughput

0.470

High

1249892

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

8

High-throughput

0.470

High

1249897

NEK7
Serine/threonine-protein kinase Nek7

1

6

High-throughput

0.470

High

851145

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

3

Small-scale

0.462

High

377829

IGF2
Insulin-like growth factor 2

1

1

High-throughput

0.457

High

871162

REG1B
Lithostathine-1-beta

1

8

High-throughput

0.457

High

895585

SERPH
Serpin H1

1

2

High-throughput

0.457

High

1249916

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.457

High

167455

WNT9A
Protein Wnt-9a

1

11

High-throughput

0.445

High

389841

TTHY
Transthyretin

1

0

High-throughput

0.438

High

518655

SRGN
Serglycin

1

0

High-throughput

0.438

High

572747

PA2GA
Phospholipase A2, membrane associated

1

0

High-throughput

0.438

High

631809

TKN1
Protachykinin-1

1

0

High-throughput

0.438

High

558983

LYL1
Protein lyl-1

1

4

High-throughput

0.437

High

1249889

ZPBP2
Zona pellucida-binding protein 2

1

2

High-throughput

0.437

High

1249914

T106B
Transmembrane protein 106B

1

4

High-throughput

0.437

High

1249917

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.437

High

405492

KITH
Thymidine kinase, cytosolic

1

1

High-throughput

0.417

High

607941

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

3

Small-scale

0.417

High

665265

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

1

High-throughput

0.417

High

808098

CDN1A
Cyclin-dependent kinase inhibitor 1

1

1

High-throughput

0.417

High

891636

GSK3B
Glycogen synthase kinase-3 beta

1

5

High-throughput

0.417

High

920051

PLK1
Serine/threonine-protein kinase PLK1

1

4

High-throughput

0.417

High

933946

NR1H2
Oxysterols receptor LXR-beta

1

2

High-throughput

0.417

High

988459

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.417

High

995095

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.417

High

1161117

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.417

High

1249918

FZD4
Frizzled-4

1

3

High-throughput

0.417

High

327063

NXPH3
Neurexophilin-3

1

6

High-throughput

0.407

High

354861

DNAL4
Dynein axonemal light chain 4

1

0

High-throughput

0.279

Low

1249895

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.279

Low

1249907

DUS15
Dual specificity protein phosphatase 15

1

0

High-throughput

0.279

Low

1249913

IGSF5
Immunoglobulin superfamily member 5

1

0

High-throughput

0.279

Low

47350

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

788072

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.268

Low

216468

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.265

Low

1249910

CH033
UPF0488 protein C8orf33

1

0

High-throughput

0.265

Low

616336

RCC1
Regulator of chromosome condensation

1

0

High-throughput

0.238

Low

1025473

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.238

Low

1109305

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.238

Low

1160496

SMN
Survival motor neuron protein

1

0

High-throughput

0.238

Low

1249915

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025