Protein: ELO3
Fatty acid elongase 3 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELO3) (Affecting plasma membrane ATPase activity protein 1) (Elongation of fatty acids protein 3) (Suppressor of RAD3 essential function protein 1) (Suppressor of Rvs161 and Rvs167 mutations protein 4) (Very-long-chain 3-oxoacyl-CoA synthase 3) (v-SNARE bypass mutant gene 1 protein)

Gene: ELO3
Organism: Saccharomyces cerevisiae S288C
Interactions: 177
UniProt ID: P40319

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006633 - fatty acid biosynthetic process
GO:0006892 - post-Golgi vesicle-mediated transport
GO:0009922 - fatty acid elongase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

762773

ELO1
Fatty acid elongase 1

1

4

High-throughput

0.698

High

771670

TECR
Very-long-chain enoyl-CoA reductase

3

5

Small-scale

0.658

High

520267

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

2

1

High-throughput

0.614

High

659164

LAC1
Ceramide synthase LAC1

2

8

High-throughput

0.614

High

698420

EMP24
Endosomal protein P24B

2

4

High-throughput

0.614

High

701459

SC61A
Protein transport protein SEC61

2

3

High-throughput

0.614

High

707425

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

2

1

High-throughput

0.614

High

749033

SSH1
Sec sixty-one protein homolog

2

3

High-throughput

0.614

High

756015

NSG1
Protein NSG1

2

1

High-throughput

0.614

High

771632

ERV14
ER-derived vesicles protein ERV14

2

1

High-throughput

0.614

High

771638

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

2

1

High-throughput

0.614

High

491402

HSP71
Heat shock protein SSA1

4

5

High-throughput

0.608

High

771616

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

2

4

High-throughput

0.608

High

771647

GSF2
Glucose-signaling factor 2

2

0

High-throughput

0.588

High

747353

PHO88
SRP-independent targeting protein 3

2

1

High-throughput

0.584

High

389544

CAN1
Arginine permease CAN1

1

18

High-throughput

0.541

High

419425

HIP1
Histidine permease

1

18

High-throughput

0.541

High

547997

SEC11
Signal peptidase complex catalytic subunit SEC11

1

1

High-throughput

0.541

High

556555

ERD1
Protein ERD1

1

1

High-throughput

0.541

High

561981

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

1

High-throughput

0.541

High

604736

EPT1
Choline/ethanolaminephosphotransferase 1

1

1

High-throughput

0.541

High

628710

PHO84
Inorganic phosphate transporter PHO84

1

6

High-throughput

0.541

High

630726

AGP1
General amino acid permease AGP1

1

17

High-throughput

0.541

High

689097

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

1

High-throughput

0.541

High

704754

SGE1
Protein SGE1

1

9

High-throughput

0.541

High

716150

CSG2
Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2

1

2

High-throughput

0.541

High

743991

TAT1
Valine/tyrosine/tryptophan amino-acid permease 1

1

17

High-throughput

0.541

High

747994

YPC1
Alkaline ceramidase YPC1

1

1

High-throughput

0.541

High

749097

BSD2
Metal homeostatis protein BSD2

1

2

High-throughput

0.541

High

755561

ERP5
Protein ERP5

1

4

High-throughput

0.541

High

756109

YHU0
UPF0641 membrane protein YHR140W

1

2

High-throughput

0.541

High

756147

CHS7
Chitin synthase export chaperone

1

2

High-throughput

0.541

High

758832

SUR2
Sphingolipid C4-hydroxylase SUR2

1

6

High-throughput

0.541

High

758859

FET3
Iron transport multicopper oxidase FET3

1

2

High-throughput

0.541

High

771607

MMM1
Maintenance of mitochondrial morphology protein 1

1

1

High-throughput

0.541

High

771608

BAP3
Valine amino-acid permease

1

17

High-throughput

0.541

High

771611

EMP47
Protein EMP47

1

1

High-throughput

0.541

High

771615

PHO86
Inorganic phosphate transporter PHO86

1

1

High-throughput

0.541

High

771617

SPC1
Signal peptidase complex subunit 1

1

3

High-throughput

0.541

High

771624

GPI8
GPI-anchor transamidase

1

2

High-throughput

0.541

High

771629

ERG25
C-4 methylsterol oxidase ERG25

1

6

High-throughput

0.541

High

771636

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

2

High-throughput

0.541

High

771642

NHX1
Endosomal/prevacuolar sodium/hydrogen exchanger

1

1

High-throughput

0.541

High

771657

PMT7
Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7

1

5

High-throughput

0.541

High

771661

THI73
Thiamine pathway transporter THI73

1

10

High-throughput

0.541

High

771666

POM33
Pore membrane protein of 33 kDa

1

2

High-throughput

0.541

High

771668

MMP1
S-methylmethionine permease 1

1

17

High-throughput

0.541

High

771612

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.533

High

494114

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.521

High

511526

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.521

High

767649

IMB4
Importin subunit beta-4

2

3

High-throughput

0.521

High

731903

MCD4
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.518

High

743855

YRO2
Protein YRO2

1

0

High-throughput

0.518

High

756629

GPI16
GPI transamidase component GPI16

1

0

High-throughput

0.518

High

767880

SHO1
High osmolarity signaling protein SHO1

1

0

High-throughput

0.518

High

771620

YJY5
Uncharacterized endoplasmic reticulum membrane protein YJR015W

1

0

High-throughput

0.518

High

771655

CSC1
Calcium permeable stress-gated cation channel 1

1

0

High-throughput

0.518

High

771672

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4

1

0

High-throughput

0.518

High

768572

SSB2
Ribosome-associated molecular chaperone SSB2

2

3

High-throughput

0.504

High

635255

FEN2
Pantothenate transporter FEN2

1

10

High-throughput

0.494

High

690448

HXT1
Low-affinity glucose transporter HXT1

1

5

High-throughput

0.494

High

700238

PMP1
Plasma membrane ATPase proteolipid 1

1

2

High-throughput

0.494

High

745063

MAL31
Maltose permease MAL31

1

10

High-throughput

0.494

High

753265

COS8
Protein COS8

1

10

High-throughput

0.494

High

753297

YHE2
Putative uncharacterized protein YHL042W

1

9

High-throughput

0.494

High

771603

HXT8
Hexose transporter HXT8

1

5

High-throughput

0.494

High

771604

VTH2
VPS10 homolog 2

1

1

High-throughput

0.494

High

771606

PMP2
Plasma membrane ATPase proteolipid 2

1

2

High-throughput

0.494

High

771610

COS4
Protein COS4

1

10

High-throughput

0.494

High

771628

AVT4
Vacuolar amino acid transporter 4

1

4

High-throughput

0.494

High

771630

MAL11
General alpha-glucoside permease

1

10

High-throughput

0.494

High

771631

VPS73
Vacuolar protein sorting-associated protein 73

1

6

High-throughput

0.494

High

771633

TNA1
High-affinity nicotinic acid transporter

1

11

High-throughput

0.494

High

771634

COS6
Protein COS6

1

10

High-throughput

0.494

High

771637

HXT11
Hexose transporter HXT11

1

5

High-throughput

0.494

High

771641

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

5

High-throughput

0.494

High

771653

TPO3
Polyamine transporter 3

1

9

High-throughput

0.494

High

771658

MCH1
Probable transporter MCH1

1

1

High-throughput

0.494

High

771660

TPO1
Polyamine transporter 1

1

9

High-throughput

0.494

High

771662

GAS4
1,3-beta-glucanosyltransferase GAS4

1

5

High-throughput

0.494

High

771665

YP264
Probable transport protein YPL264C

1

1

High-throughput

0.494

High

771669

POM34
Nucleoporin POM34

1

1

High-throughput

0.494

High

520345

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

1

High-throughput

0.479

High

541727

SEC63
Protein translocation protein SEC63

1

2

High-throughput

0.479

High

596984

ACO1
Acyl-CoA desaturase 1

1

1

High-throughput

0.479

High

625999

SPTC1
Serine palmitoyltransferase 1

1

1

High-throughput

0.479

High

629476

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

2

High-throughput

0.479

High

669534

ERG9
Squalene synthase ERG9

1

1

High-throughput

0.479

High

679913

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

5

High-throughput

0.479

High

688602

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

6

High-throughput

0.479

High

701647

SRPR
Signal recognition particle receptor subunit alpha homolog

1

1

High-throughput

0.479

High

704631

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

3

High-throughput

0.479

High

707491

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

5

High-throughput

0.479

High

728037

YET1
Endoplasmic reticulum transmembrane protein 1

1

4

High-throughput

0.479

High

747797

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

5

High-throughput

0.479

High

752766

LAG1
Ceramide synthase LAG1

1

8

High-throughput

0.479

High

759058

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

1

1

High-throughput

0.479

High

765998

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

4

High-throughput

0.479

High

771602

SNL1
HSP70 co-chaperone SNL1

1

1

High-throughput

0.479

High

771605

LCB2
Serine palmitoyltransferase 2

1

1

High-throughput

0.479

High

771613

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

2

High-throughput

0.479

High

771618

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

5

High-throughput

0.479

High

771622

STE24
CAAX prenyl protease 1

1

1

High-throughput

0.479

High

771623

HLJ1
Protein HLJ1

1

1

High-throughput

0.479

High

771646

HFD1
Fatty aldehyde dehydrogenase HFD1

1

5

High-throughput

0.479

High

771649

RTN1
Reticulon-like protein 1

1

2

High-throughput

0.479

High

771659

YET3
Endoplasmic reticulum transmembrane protein 3

1

4

High-throughput

0.479

High

771664

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

1

1

High-throughput

0.479

High

400179

CHO2
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.458

High

634317

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

635200

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

688574

ERG2
C-8 sterol isomerase ERG2

1

0

High-throughput

0.458

High

707202

SEC66
Translocation protein SEC66

1

0

High-throughput

0.458

High

733706

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.458

High

752287

MSC7
Putative aldehyde dehydrogenase-like protein YHR039C

1

0

High-throughput

0.458

High

753834

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

756652

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

771621

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

771635

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

0

High-throughput

0.458

High

771644

CUE4
CUE domain-containing protein CUE4

1

0

High-throughput

0.458

High

771650

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.458

High

771651

YP114
Uncharacterized TLC domain-containing protein YPR114W

1

0

High-throughput

0.458

High

771654

LOA1
Lysophosphatidic acid:oleoyl-CoA acyltransferase 1

1

0

High-throughput

0.458

High

771671

SEY1
Protein SEY1

1

0

High-throughput

0.458

High

771673

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.458

High

474111

MPH3
Alpha-glucosides permease MPH3

1

10

High-throughput

0.439

High

771601

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.439

High

680756

HS104
Heat shock protein 104

1

1

High-throughput

0.437

High

687952

IMB3
Importin subunit beta-3

1

4

High-throughput

0.437

High

711115

YKK0
Probable intramembrane protease YKL100C

1

2

High-throughput

0.437

High

746504

IMB2
Importin subunit beta-2

1

3

High-throughput

0.437

High

771625

TOM22
Mitochondrial import receptor subunit TOM22

1

1

High-throughput

0.437

High

771640

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.437

High

771652

IMB1
Importin subunit beta-1

1

3

High-throughput

0.437

High

334712

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

High-throughput

0.407

High

388986

SYTC
Threonine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.407

High

389925

VDAC1
Mitochondrial outer membrane protein porin 1

1

1

High-throughput

0.407

High

404606

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.407

High

415996

DED1
ATP-dependent RNA helicase DED1

1

2

High-throughput

0.407

High

498954

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.407

High

556082

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

694809

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.407

High

752912

YHI0
Putative proline--tRNA ligase YHR020W

1

1

High-throughput

0.407

High

771626

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.407

High

771667

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.407

High

368114

EF1A
Elongation factor 1-alpha

2

0

High-throughput

0.298

High

525821

KEX2
Kexin

1

0

High-throughput

0.282

High

621412

VATO
V-type proton ATPase subunit c''

1

0

High-throughput

0.282

High

704036

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

0

High-throughput

0.282

High

771656

OPT2
Oligopeptide transporter 2

1

0

High-throughput

0.282

High

614974

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.261

Low

606662

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

634631

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

676105

XPO1
Exportin-1

1

0

High-throughput

0.249

Low

707867

GCN1
eIF-2-alpha kinase activator GCN1

1

0

High-throughput

0.249

Low

733020

YKR18
IML2-like protein YKR018C

1

0

High-throughput

0.249

Low

756943

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

762255

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

771609

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

771614

NUP85
Nucleoporin NUP85

1

0

High-throughput

0.249

Low

771619

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

771639

PNG1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

0

High-throughput

0.249

Low

771643

SXM1
Importin beta SMX1

1

0

High-throughput

0.249

Low

771645

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

771648

TVP18
Golgi apparatus membrane protein TVP18

1

0

High-throughput

0.249

Low

771663

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

333810

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.232

Low

358096

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.232

Low

360900

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

399496

RLA0
Large ribosomal subunit protein uL10

1

0

High-throughput

0.232

Low

405205

RL17A
Large ribosomal subunit protein uL22A

1

0

High-throughput

0.232

Low

410135

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

0

High-throughput

0.232

Low

454349

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.232

Low

627628

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.232

Low

706306

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.232

Low

751371

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.232

Low

771627

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024