Protein: XRCC4
DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)]

Gene: XRCC4
Organism: Homo sapiens
Interactions: 87
UniProt ID: Q13426

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005958 - DNA-dependent protein kinase-DNA ligase 4 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

892676

DNLI4
DNA ligase 4

23

1

Small-scale

0.992

High

1104902

XRCC4
DNA repair protein XRCC4

10

0

Small-scale

0.930

High

1104935

NHEJ1
Non-homologous end-joining factor 1

9

0

Small-scale

0.925

High

1104909

IFFO2
Intermediate filament family orphan 2

4

2

High-throughput

0.797

High

1104930

PNKP
Bifunctional polynucleotide phosphatase/kinase

9

1

Small-scale

0.756

High

1104913

APTX
Aprataxin

7

1

Small-scale

0.746

High

1104914

K1C27
Keratin, type I cytoskeletal 27

2

0

High-throughput

0.742

High

1068829

IFFO1
Non-homologous end joining factor IFFO1

6

2

Small-scale

0.740

High

1104917

APLF
Aprataxin and PNK-like factor

7

0

Small-scale

0.712

High

1104918

FAM9B
Protein FAM9B

6

0

High-throughput

0.703

High

558105

XRCC6
X-ray repair cross-complementing protein 6

4

1

Small-scale

0.698

High

1104923

APBP2
Amyloid protein-binding protein 2

4

2

High-throughput

0.691

High

474652

VIME
Vimentin

1

0

High-throughput

0.663

High

626210

NFKB1
Nuclear factor NF-kappa-B p105 subunit

4

0

High-throughput

0.661

High

883092

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

3

0

High-throughput

0.638

High

876847

KC1A
Casein kinase I isoform alpha

2

1

High-throughput

0.628

High

991514

DYL1
Dynein light chain 1, cytoplasmic

2

1

High-throughput

0.628

High

1008130

PRKDC
DNA-dependent protein kinase catalytic subunit

3

0

Small-scale

0.619

High

1041985

LMNB2
Lamin-B2

1

2

High-throughput

0.618

High

1104926

DYL2
Dynein light chain 2, cytoplasmic

2

1

High-throughput

0.611

High

1104906

LONF2
LON peptidase N-terminal domain and RING finger protein 2

3

1

High-throughput

0.609

High

848377

MAGA6
Melanoma-associated antigen 6

2

1

High-throughput

0.606

High

1104916

RN135
E3 ubiquitin-protein ligase RNF135

2

0

High-throughput

0.602

High

1104928

UIF
UAP56-interacting factor

2

0

High-throughput

0.602

High

1104936

SHCAF
SIN3-HDAC complex-associated factor

2

0

High-throughput

0.602

High

1104937

MED4
Mediator of RNA polymerase II transcription subunit 4

2

0

High-throughput

0.602

High

1104925

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.598

High

262072

NBN
Nibrin

1

0

Small-scale

0.589

High

487271

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.586

High

559340

XRCC5
X-ray repair cross-complementing protein 5

2

1

Small-scale

0.584

High

192371

GSC2
Homeobox protein goosecoid-2

2

0

High-throughput

0.580

High

1104939

HAUS2
HAUS augmin-like complex subunit 2

2

0

High-throughput

0.580

High

385715

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

Small-scale

0.575

High

138488

BIN1
Myc box-dependent-interacting protein 1

1

0

Small-scale

0.561

High

1104931

PAXX
Protein PAXX

2

0

Small-scale

0.559

High

1104907

ASTE1
Single-strand DNA endonuclease ASTE1

1

0

High-throughput

0.549

High

682482

S100P
Protein S100-P

1

2

High-throughput

0.536

High

686808

S10A4
Protein S100-A4

1

2

High-throughput

0.536

High

848613

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.536

High

877102

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.536

High

555676

ACTN1
Alpha-actinin-1

1

0

High-throughput

0.518

High

1088325

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.518

High

1104905

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.513

High

1104919

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.513

High

1104920

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.513

High

1104924

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.513

High

1104938

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

997688

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.494

High

1037139

H11
Histone H1.1

1

0

High-throughput

0.493

High

706117

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

1104910

KLC3
Kinesin light chain 3

1

2

High-throughput

0.489

High

185662

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

473968

NFIC
Nuclear factor 1 C-type

1

2

High-throughput

0.479

High

1087723

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.479

High

1104904

NFIX
Nuclear factor 1 X-type

1

2

High-throughput

0.479

High

1104944

KIF3A
Kinesin-like protein KIF3A

1

1

High-throughput

0.479

High

1104929

DCR1C
Protein artemis

1

0

Small-scale

0.464

High

259900

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

540856

ERG
Transcriptional regulator ERG

1

0

Small-scale

0.458

High

606725

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

695376

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

767197

MERL
Merlin

1

0

High-throughput

0.458

High

768111

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

851760

NKX21
Homeobox protein Nkx-2.1

1

0

High-throughput

0.458

High

860188

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.458

High

926345

BLM
RecQ-like DNA helicase BLM

1

0

Small-scale

0.458

High

1104903

CUL1
Cullin-1

1

0

Small-scale

0.458

High

1104908

SETMR
Histone-lysine N-methyltransferase SETMAR

1

0

Small-scale

0.458

High

1104921

DNJC9
DnaJ homolog subfamily C member 9

1

0

High-throughput

0.458

High

1104922

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1104932

CYREN
Cell cycle regulator of non-homologous end joining

1

0

Small-scale

0.458

High

1104940

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1104941

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.458

High

1104943

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

0

High-throughput

0.458

High

1029675

FOXK2
Forkhead box protein K2

1

0

High-throughput

0.426

High

1104927

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.426

High

1104933

RNF41
E3 ubiquitin-protein ligase NRDP1

1

0

High-throughput

0.426

High

116975

J3KPF9
Kinesin-like protein

1

1

High-throughput

0.407

High

1104934

CAAP1
Caspase activity and apoptosis inhibitor 1

1

0

High-throughput

0.282

High

287289

RF1M
Peptide chain release factor 1, mitochondrial

1

0

High-throughput

0.279

Low

1104915

ERIC1
Glutamate-rich protein 1

1

0

High-throughput

0.269

Low

1104911

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

0

High-throughput

0.249

Low

1104912

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1104942

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

160817

TOR1B
Torsin-1B

1

0

High-throughput

0.232

Low

607367

HLAG
HLA class I histocompatibility antigen, alpha chain G

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025