Protein: ZWINT
Outer kinetochore KNL1 complex subunit ZWINT (ZW10 interactor) (ZW10-interacting protein 1) (Zwint-1)

Gene: ZWINT
Organism: Homo sapiens
Interactions: 149
UniProt ID: O95229

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000776 - kinetochore
GO:0000940 - outer kinetochore
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

329950

KNL1
Outer kinetochore KNL1 complex subunit KNL1

9

1

Small-scale

0.975

High

329949

SPC24
Kinetochore protein Spc24

8

1

Small-scale

0.751

High

329974

MIS12
Protein MIS12 homolog

11

0

Small-scale

0.727

High

329976

DSN1
Kinetochore-associated protein DSN1 homolog

10

0

Small-scale

0.725

High

163881

NDC80
Kinetochore protein NDC80 homolog

10

0

Small-scale

0.724

High

329960

NSL1
Kinetochore-associated protein NSL1 homolog

8

0

Small-scale

0.718

High

329979

SPC25
Kinetochore protein Spc25

7

0

High-throughput

0.714

High

329939

PMF1
Polyamine-modulated factor 1

7

0

Small-scale

0.710

High

329971

NUF2
Kinetochore protein Nuf2

6

0

High-throughput

0.702

High

329920

BFSP1
Filensin

3

4

High-throughput

0.665

High

329999

MTMR6
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6

4

0

High-throughput

0.664

High

329901

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

4

0

High-throughput

0.661

High

329925

BECN1
Beclin-1

3

0

Small-scale

0.643

High

329912

MLF1
Myeloid leukemia factor 1

3

0

High-throughput

0.638

High

329984

LYRM4
LYR motif-containing protein 4

3

0

High-throughput

0.638

High

330000

NEUR2
Sialidase-2

3

0

High-throughput

0.638

High

330003

NFS1
Cysteine desulfurase

3

0

High-throughput

0.638

High

329990

RRBP1
Ribosome-binding protein 1

4

1

High-throughput

0.636

High

50887

SYCE3
Synaptonemal complex central element protein 3

3

0

High-throughput

0.634

High

329986

EXOC1
Exocyst complex component 1

3

0

High-throughput

0.634

High

224068

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

2

1

High-throughput

0.621

High

329883

K2C75
Keratin, type II cytoskeletal 75

2

1

High-throughput

0.606

High

257079

CCD22
Coiled-coil domain-containing protein 22

2

0

High-throughput

0.602

High

297896

SPF27
Pre-mRNA-splicing factor SPF27

2

0

High-throughput

0.580

High

329953

CCHCR
Coiled-coil alpha-helical rod protein 1

2

0

High-throughput

0.580

High

329966

TS101
Tumor susceptibility gene 101 protein

2

0

High-throughput

0.580

High

286611

STX11
Syntaxin-11

2

2

High-throughput

0.574

High

329948

STX19
Syntaxin-19

2

2

High-throughput

0.574

High

211706

ZW10
Centromere/kinetochore protein zw10 homolog

2

0

Small-scale

0.563

High

329885

P53
Cellular tumor antigen p53

2

0

Small-scale

0.559

High

73740

B2RNG4
RING-type E3 ubiquitin transferase

1

3

High-throughput

0.536

High

300614

KRT37
Keratin, type I cuticular Ha7

1

3

High-throughput

0.536

High

300710

KRT38
Keratin, type I cuticular Ha8

1

3

High-throughput

0.536

High

329894

S100P
Protein S100-P

1

1

High-throughput

0.536

High

329915

KRT83
Keratin, type II cuticular Hb3

1

1

High-throughput

0.536

High

329923

STX3
Syntaxin-3

1

2

High-throughput

0.536

High

329970

TRI34
E3 ubiquitin-protein ligase TRIM34

1

3

High-throughput

0.536

High

251687

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

2

High-throughput

0.515

High

329884

SNP29
Synaptosomal-associated protein 29

1

1

High-throughput

0.515

High

329892

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

High-throughput

0.515

High

329893

LMNB1
Lamin-B1

1

3

High-throughput

0.515

High

329897

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.515

High

329910

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

1

High-throughput

0.515

High

329922

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.515

High

329957

DDX17
Probable ATP-dependent RNA helicase DDX17

1

1

High-throughput

0.515

High

329972

TRIM5
Tripartite motif-containing protein 5

1

3

High-throughput

0.515

High

67595

RHG32
Rho GTPase-activating protein 32

1

0

High-throughput

0.513

High

192676

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

High-throughput

0.513

High

282335

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

High-throughput

0.513

High

329889

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.513

High

329898

HSP74
Heat shock 70 kDa protein 4

1

0

High-throughput

0.513

High

329905

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.513

High

329908

RBM25
RNA-binding protein 25

1

0

High-throughput

0.513

High

329924

RIN1
Ras and Rab interactor 1

1

0

High-throughput

0.513

High

329927

TAF12
Transcription initiation factor TFIID subunit 12

1

0

High-throughput

0.513

High

329932

RABL6
Rab-like protein 6

1

0

High-throughput

0.513

High

329937

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.513

High

329941

CC174
Coiled-coil domain-containing protein 174

1

0

High-throughput

0.513

High

329947

SUGP1
SURP and G-patch domain-containing protein 1

1

0

High-throughput

0.513

High

329954

IPO4
Importin-4

1

0

High-throughput

0.513

High

329955

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.513

High

329958

SCMH1
Polycomb protein SCMH1

1

0

High-throughput

0.513

High

329964

HTF4
Transcription factor 12

1

0

High-throughput

0.513

High

329969

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

329982

E41L5
Band 4.1-like protein 5

1

0

High-throughput

0.513

High

329985

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

High-throughput

0.513

High

329988

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

0

High-throughput

0.513

High

329992

TRMB
tRNA

1

0

High-throughput

0.513

High

329993

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

0

High-throughput

0.513

High

329881

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.493

High

329914

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.493

High

329917

CENPC
Centromere protein C

1

0

High-throughput

0.493

High

167209

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

329896

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

329978

PHAX
Phosphorylated adapter RNA export protein

1

0

High-throughput

0.486

High

329886

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

329907

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

Small-scale

0.479

High

329911

SMTN
Smoothelin

1

1

High-throughput

0.479

High

329918

Q05C46
CASC5 protein

1

1

High-throughput

0.479

High

329921

IFT88
Intraflagellar transport protein 88 homolog

1

1

High-throughput

0.479

High

329938

TTBK2
Tau-tubulin kinase 2

1

1

High-throughput

0.479

High

329942

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

329944

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

329946

Q8IWY7
Keratin, type II cytoskeletal 8

1

3

High-throughput

0.479

High

330001

TRI17
E3 ubiquitin-protein ligase TRIM17

1

3

Small-scale

0.479

High

329891

CLUS
Clusterin

1

0

Small-scale

0.460

High

329909

DNLI4
DNA ligase 4

1

0

High-throughput

0.460

High

329882

EYA4
Protein phosphatase EYA4

1

0

High-throughput

0.458

High

329895

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

329899

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

329904

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

329916

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

329919

CDC20
Cell division cycle protein 20 homolog

1

0

Small-scale

0.458

High

329928

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.458

High

329933

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.458

High

329952

NEDD1
Protein NEDD1

1

0

High-throughput

0.458

High

329962

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

329977

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

329987

FBX28
F-box only protein 28

1

0

High-throughput

0.458

High

329998

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

0

Small-scale

0.458

High

117230

K7EJH0
Kinetochore protein Spc24

1

1

High-throughput

0.445

High

75782

B3KY54
cDNA FLJ46886 fis, clone UTERU3016308, highly similar to Smoothelin

1

1

High-throughput

0.437

High

329887

NFM
Neurofilament medium polypeptide

1

2

High-throughput

0.437

High

329989

ZSWM5
Zinc finger SWIM domain-containing protein 5

1

1

High-throughput

0.437

High

329997

SSRG
Translocon-associated protein subunit gamma

1

1

High-throughput

0.437

High

181593

CETN3
Centrin-3

1

0

Small-scale

0.426

High

329903

NUP62
Nuclear pore glycoprotein p62

1

0

High-throughput

0.426

High

329906

MAGAA
Melanoma-associated antigen 10

1

0

High-throughput

0.426

High

329936

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

91618

C9JA28
Translocon-associated protein subunit gamma

1

1

High-throughput

0.407

High

104296

F5H6C2
Intraflagellar transport 88

1

1

High-throughput

0.407

High

329981

ZSWM6
Zinc finger SWIM domain-containing protein 6

1

1

High-throughput

0.407

High

329991

STX18
Syntaxin-18

4

0

High-throughput

0.360

High

329902

TNR3
Tumor necrosis factor receptor superfamily member 3

3

0

High-throughput

0.347

High

329996

PCOC2
Procollagen C-endopeptidase enhancer 2

3

0

High-throughput

0.345

High

329900

TSP2
Thrombospondin-2

2

0

High-throughput

0.328

High

329961

F167A
Protein FAM167A

2

0

High-throughput

0.328

High

65863

MSGN1
Mesogenin-1

2

0

High-throughput

0.316

High

329943

NUP54
Nucleoporin p54

2

0

High-throughput

0.316

High

329945

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

330002

MAFB
Transcription factor MafB

1

0

High-throughput

0.282

High

253802

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

329888

CO1A2
Collagen alpha-2(I) chain

1

0

High-throughput

0.279

Low

329930

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

329931

ASTE1
Single-strand DNA endonuclease ASTE1

1

0

High-throughput

0.279

Low

329934

TJAP1
Tight junction-associated protein 1

1

0

High-throughput

0.279

Low

329935

RAIN
Ras-interacting protein 1

1

0

High-throughput

0.279

Low

329951

PLBL2
Putative phospholipase B-like 2

1

0

High-throughput

0.279

Low

329956

AP3S1
AP-3 complex subunit sigma-1

1

0

High-throughput

0.279

Low

329963

LENG8
Leukocyte receptor cluster member 8

1

0

High-throughput

0.279

Low

329965

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

329967

KIFC3
Kinesin-like protein KIFC3

1

0

High-throughput

0.279

Low

329973

T126A
Transmembrane protein 126A

1

0

High-throughput

0.279

Low

329975

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.279

Low

329980

TPC
Mitochondrial thiamine pyrophosphate carrier

1

0

High-throughput

0.279

Low

329995

ING1
Inhibitor of growth protein 1

1

0

High-throughput

0.279

Low

330004

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.279

Low

142038

CCN1
CCN family member 1

1

0

High-throughput

0.269

Low

329926

RCN1
Reticulocalbin-1

1

0

High-throughput

0.269

Low

329968

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low

136760

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.249

Low

329913

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.249

Low

329940

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

329959

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

329983

RM47
Large ribosomal subunit protein uL29m

1

0

High-throughput

0.249

Low

329994

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.249

Low

329890

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low

329929

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025